Analysis of Risk Factors for Outcomes After Unrelated Cord Blood Transplantation in Adults With Lymphoid Malignancies: A Study by the Eurocord-Netcord and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation

Abstract

UCBT is a viable treatment for adults with advanced lymphoid malignancies. Chemosensitive disease, use of low-dose TBI, and higher cell dose were factors associated with significantly better outcome.

Future of cord blood for oncology uses

“…56,59,62,63,65 Similar observations have been made in the reduced-intensity setting. 40,41,56 Patients with acute leukemia in CR receiving a two UCB have a lower relapse risk compared with those who received one UCB unit. 66 This observation has now been reproduced.…”

“…66 This observation has now been reproduced. 56,63 However, this enhanced alloreactivity and reduced relapse risk have also been associated with an increased incidence of acute GVHD, 67 though the excess risk was primarily grade II skin GVHD. Grade III-IV acute GVHD is not increased after double UCB grafting.…”

“…Recent reports are providing the first insights into disease-specific outcomes for this disease group. 47,[54][55][56][57] The reported PFS for patients with intermediate and low grade lymphoid malignancies ranges from 20 to 50%. Comparisons between recipients of UCB and related PBSC grafts who were either X55 years 58 or who had AML 55 found similar outcomes using either graft source.…”

“…38,39,59,60 There is growing interest on investigating this strategy for the treatment of adult patients with hematological malignancies in both the myeloablative conditioning and RIC settings. 29,40,41,56,[61][62][63][64] In the myeloablative setting, double cord transplantation for adults has been shown to produce reproducible engraftment, low TRM and PFS similar to other stem cell sources. 56,59,62,63,65 Similar observations have been made in the reduced-intensity setting.…”

“…29,40,41,56,[61][62][63][64] In the myeloablative setting, double cord transplantation for adults has been shown to produce reproducible engraftment, low TRM and PFS similar to other stem cell sources. 56,59,62,63,65 Similar observations have been made in the reduced-intensity setting. 40,41,56 Patients with acute leukemia in CR receiving a two UCB have a lower relapse risk compared with those who received one UCB unit.…”