Analysis of risk factors for complications and adverse obstetrical outcomes in women with Takayasu arteritis: a French retrospective study and literature review

Abisror, Noémie; Mékinian, A.; Hachulla, É.; Lambert, Marc; Morel, Nathalie; Chapelon, C.; Martis, N.; Fuzibet, Jean Gabriel; Bélénotti, P.; Swiader, L.; Dhôte, Robin; Mouthon, Luc; Sarrot-Reynault, Françoise; André, M.; Amar, Smail; Gauthier, Jean; Cathébras, P.; Néel, A.; Vandergheynst, Frédéric; Rondeau, M.; Fur, Alain; Renou, F.; Godeau, Bertrand; Devaux, Bruno; Veyssier-Belot, C; Cacoub, P.; Pourrât, O.; Haroche, Julien; Maurier, F.; Lahuna, Constance; Fain, Olivier; Guillevin, Loı̈c; Guern, Véronique Le; Costédoat-Chalumeau, Nathalie

doi:10.1007/s10067-020-05024-4

Cited by 22 publications

(26 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Obstetrical complications included 35% of arterial hypertension (n = 15), 9% of pre-eclampsia (n = 4), 2% of HELLP syndrome (n = 1) and 14% of IUGR (n = 6), leading in one case to a medically indicated termination of pregnancy. Obstetrical complications were more frequent in TAK patients with arterial hypertension, renal artery stenosis and infra-diaphragmatic artery involvement (8). Despite frequent obstetrical complications, no significant impact was observed on live birth rates with 98% of live births.…”

Section: Pregnancy Outcome In Patients With Established Takayasu Arteritismentioning

confidence: 86%

“…We reported that factors associated with risks of obstetric and maternal complications were smoking and active TAK disease with an NIH score >1 (5). Abisror et al also reported a high rate of obstetrical complications (47%) in women with Takayasu arteritis (8). Obstetrical complications included 35% of arterial hypertension (n = 15), 9% of pre-eclampsia (n = 4), 2% of HELLP syndrome (n = 1) and 14% of IUGR (n = 6), leading in one case to a medically indicated termination of pregnancy.…”

Section: Pregnancy Outcome In Patients With Established Takayasu Arteritismentioning

confidence: 95%

“…Takayasu arteritis can have a preclinical period and a long prodromal phase. Few studies described foetal and maternal outcomes in women before TAK diagnosis (4)(5)(6)(7)(8)(9). However, none of these studies analysing pregnancies before established TAK disease described inflammation markers or vascular imaging.…”

Section: Pregnancy Outcome Before Established Tak Diseasementioning

confidence: 99%

See 2 more Smart Citations

Pregnancy issues in Takayasu arteritis

Comarmond

Saadoun

Nizard

et al. 2020

Seminars in Arthritis and Rheumatism

Self Cite

View full text Add to dashboard Cite

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

show abstract

Section: Pregnancy Outcome In Patients With Established Takayasu Arteritismentioning

confidence: 86%

Section: Pregnancy Outcome In Patients With Established Takayasu Arteritismentioning

confidence: 95%

Section: Pregnancy Outcome Before Established Tak Diseasementioning

confidence: 99%

See 1 more Smart Citation

Pregnancy issues in Takayasu arteritis

Comarmond

Saadoun

Nizard

et al. 2020

Seminars in Arthritis and Rheumatism

Self Cite

View full text Add to dashboard Cite

show abstract

“…In contrast, other studies have shown poor obstetrical outcomes with vascular involvement 1,14 . A French multicentre group showed that adverse obstetrical events were more common in TA with infra‐diaphragmatic artery involvement and renal artery stenosis 46 . In an observational study published recently, it was seen that renal artery intervention before conception was associated with better fetomaternal outcomes 47 .…”

Section: Management Of Takayasyu Arteritis In Pregnancymentioning

confidence: 97%

Update on pregnancy in Takayasu arteritis—A narrative review

et al. 2021

View full text Add to dashboard Cite

Takayasu arteritis (TA) is a chronic, idiopathic large‐vessel vasculitis that affects women of reproductive age, and has significant maternal and fetal implications. Although there are contrasting data on the effect of TA on fertility, most studies have shown that fertility outcomes remain unaffected. The disease activity of TA usually either remains stable or decreases during pregnancy. The important fetomaternal complications are maternal hypertension, pre‐eclampsia, prematurity, and intrauterine growth restriction. To reduce maternal and fetal morbidity, controlling the disease before conception is important. This review article discusses the various implications, challenges, and medical and endovascular management of TA during pregnancy.

show abstract

“…So far, there are a few small sample studies on the pregnancy outcomes of TAK patients in the literature with contradictory results [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. Some studies suggested that pregnancies in women with TAK could result in high rates of maternal hypertension (5.3% to 100%) and preeclampsia (2.7% to 75.9%) [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21], and active TAK was associated with poor pregnancy outcomes [11,13]. However, some studies showed that active disease was not associated with adverse pregnancy outcome [7,8].…”

Section: Introductionmentioning

confidence: 99%

Pregnancy Outcomes in Takayasu Arteritis Patients

Song

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundsTakayasu Arteritis (TAK) is a chronic inflammatory autoimmune disease with a high prevalence in women of child-bearing age. We aim to investigate the maternal complications and pregnancy outcomes in patients with TAK and identify the related factors.MethodsA total of 110 pregnancies in 80 TAK patients in a Chinese TAK patient cohort and 440 matched pregnancies in healthy women between 2000 to 2020 were included. The maternal complications and pregnancy outcomes between TAK patients and matched controls were compared by chi-square test. The logistic regression analysis was used to identify the risk factors of maternal complications and adverse pregnancy outcomes in patients with TAK.ResultsMaternal complications and adverse pregnancy outcomes were more frequent in pregnancies with TAK than that in healthy women (P<0.001). In pregnancies with TAK, the most common maternal complication was new-onset or worsening of hypertension (18.2% [20/110]) and the most prevalent obstetrical complication was spontaneous abortion (32.7% [36/110]). Hypertension (OR 5.01, 95% CI 1.61 to 16.01), heart disease (OR 15.83, 95% CI 1.99 to 125.99), and active TAK (OR 7.54, 95% CI 1.85 to 30.72) before pregnancy were independently associated with increased maternal complications. The disease duration (OR 1.12, 95% CI 1.02 to 1.23) and active disease during pregnancy (OR 14.59, 95% CI 1.81 to 117.49) were correlated with adverse pregnancy outcomes. ConclusionTAK disease itself is a risk factor for adverse pregnancy outcomes. Treating the disease to a stable state before and after pregnancy, and close collaboration between rheumatologists and obstetricians are important measures to reduce maternal complications and reach favorable pregnancy outcomes.

show abstract

Analysis of risk factors for complications and adverse obstetrical outcomes in women with Takayasu arteritis: a French retrospective study and literature review

Cited by 22 publications

References 18 publications

Pregnancy issues in Takayasu arteritis

Pregnancy issues in Takayasu arteritis

Update on pregnancy in Takayasu arteritis—A narrative review

Pregnancy Outcomes in Takayasu Arteritis Patients

Contact Info

Product

Resources

About