Analysis of retinal vessels in eyes with retinitis pigmentosa by retinal oximeter

Abstract

ABSTRACT.Purpose: To study changes in the oxygen saturation and calibre of retinal vessels in the eyes of patients with retinitis pigmentosa (RP). Method: In this cross-sectional study, 63 eyes of 63 patients with RP and 14 eyes of 14 healthy subjects were enrolled and examined at Toyama University Hospital. Retinal oximetry measurements were performed using a spectrophotometric oximetry unit (Oxymap T1, Reykjavik, Iceland), which is coupled to a fundus camera base (TRC-50DX; Topcon Corporation, Tokyo, Japan). Retinal arterioles of 28 eyes and retinal venules of 35 eyes with adequate image quality were selected for analyses. We calculated the residual areas of visual field (I-4e and V-4e isopters) in each eye and determined the correlations between the data of retinal vessels and the areas of visual field in the RP eyes. Results: The mean oxygen saturation of the venules in the RP eyes (60.2 AE 6.5%) was significantly higher than that in healthy eyes (54.6 AE 6.3%, p = 0.0089). The oxygen saturation of the venules in the RP eyes correlated significantly with the residual areas of the visual field of V-4e (r = À0.50; p = 0.0030). The mean calibres of the retinal arterioles (91.1 AE 9.1 lm) and retinal venules (116 AE 13 lm) of the RP eyes were significantly narrower than those of the healthy eyes (115 AE 11 lm and 152 AE 15 lm, respectively, p < 0.01). The retinal arteriolar and venular calibres in the RP eyes correlated with the residual areas of the visual field of V-4e (r = 0.43; p = 0.033 and r = 0.45; p = 0.011, respectively). Conclusions: The severity of RP was correlated with increased oxygen saturations in the retinal venules and decreased retinal vessel calibres.

Metabolic, structural and functional alterations in patients with inherited diseases of the retina

“…; Ueda‐Consolvo et al. ; Zong et al. ), we found once more an increased A‐SO 2 and even more, an increased V‐SO 2 , with corresponding decrease in the A‐V SO 2 values within the rod‐cone dystrophy (RCD) group (Bojinova et al.…”

HIF‐1α stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa

“…These researchers found that younger RP patients presented with higher AS and AVS, whereas older RP patients lower presented with AS and AVS (39). Ueda‐Consolvo and collaborators proposed that the severity of RP correlates with elevated oxygen saturation in the VS and decreased retinal vessel calibers (44).…”

Hyperspectral Image Mapping Spectrometry for Retinal Oximetry Measurements in Four Diseased Eyes

“…Geirsdottir, et al used the Oxymap T1 to demonstrate that oxygen saturation in retinal veins decreases with age in healthy eyes [12]. Several studies have found reduced oxygen saturation values in occluded arteries and veins [14–17] and increased venous oxygen saturation in patients with exudative age-related macular degeneration (AMD) [18], advanced primary open-angle glaucoma [19–21], diabetic retinopathy[22–24], and retinitis pigmentosa [25, 26]. For patients with retinitis pigmentosa, increased arterial oxygenation saturation and increased arteriovenous oxygen saturation differences have been observed, with age seemingly affecting these values [27, 28].…”