Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography

Vural, Gözde Şahin; Dal, Didem

doi:10.1007/s00417-019-04402-2

Cited by 7 publications

(7 citation statements)

References 57 publications

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“…The present study found an increase in the thickness of the GCC layer in adult patients with anisometropic amblyopia compared with the contralateral eyes, but no statistically signi cant change in strabismic amblyopia. This is consistent with the study by Yen et al [10] that suggested that normal apoptosis of retinal ganglion cells was blocked after birth in amblyopia, which can lead to an increase in RNFL thickness. Szigeti A et al [11] suggested that if Yen and others' hypothesis was correct, then the suppression of retinal ganglion cells' apoptosis would not only affect the thickness of the RNFL, but also result in a thickening of the GCC layer.…”

Section: Discussionsupporting

confidence: 93%

“…We speculated that the thinning of RNFL in the maculopapillary bundle may cause degeneration of central vision and corresponding excessive ganglion cell atrophy or apoptosis. Thickening in RNFL layer in other sectors might be due to the blocking of normal ganglion cells' apoptosis after birth [10].…”

Section: Discussionmentioning

confidence: 99%

“…Changes in ganglion cells after birth are considered to be one of main reasons for retinal structural alteration in amblyopia [10]. Apart from RNFL, the GCC layer includes inner plexiform layers, ganglion cell body, and nerve ber.…”

Section: Discussionmentioning

confidence: 99%

“…The above-mentioned research re ects contradictory results of RNFL thickness changes in amblyopic eyes. The present consensus regarding structural changes in the retina of patients with amblyopia mainly focuses on the ganglion cells alternations after birth [10,11]. The ganglion cell complex (GCC), comprising the nerve ber layer, ganglion cell layer, and inner plexiform layer, is a good indicator of ganglion cells status.…”

Section: Introductionmentioning

confidence: 99%

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Retinal Thickness and P-ERG Changes in Adult Patients With Anisometropic and Strabismic Amblyopia

Gao

Shao

et al. 2021

Preprint

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Objective To investigate the changes of retinal thickness and P-ERG signals in adult patients with anisometropic and strabismic amblyopia. Methods Sixty patients with monocular adult amblyopia, including 30 anisometropic amblyopes (AA group) and 30 strabismic amblyopes (SA group), were enrolled in our study at the outpatient clinic of The Hefei First People’s Hospital Hospital of Anhui medical University from June 2019 to November 2020. Retinal nerve fiber layer (RNFL) thickness was measured within 3.4 mm diameter range surrounding the optic nerve, and ganglion cell complex (GCC) layer thickness within 6 mm diameter range surrounding the fovea by an Optovue RTVue OCT in both amblyopic and fellow eyes. The amplitude and latency of P50 and N95 in P-ERG were recorded by a Roland electrophysiology instrument under two stimulation conditions with different temporal and spatial frequencies that were designed to bias the parvocellular and magnocellular pathways respectively. Data between amblyopic and fellow eyes was statistically analyzed by paired t test. The correlation between axial length and parameters of OCT and P-ERG was examined by Pearson correlation test. Results (1) Changes in RNFL thickness: In the AA group, RNFL thickness in temporal sector was significantly thinner (p = 0.033), while that in the nasal, superior and inferior sectors increased (p < 0.05) compared with fellow eyes. In SA group, no significant difference (each sector p > 0.05) was found between amblyopic eyes and fellow eyes. (2) Changes in GCC thickness: Compared with fellow eyes, in the AA group, GCC layer thickness of amblyopic eyes was significantly increased (p = 0.039), whereas in the SA group, we did not find a significant difference between amblyopic eyes and fellow eyes (p > 0.05). (3) P-ERG stimulated mode biased the parvocellular pathway: When compared with fellow eyes (n = 15), in the AA group, the amplitudes of P50 (p = 0.004) and N95 (p = 0.038) were significantly decreased in amblyopic eyes, but no significant latent time difference (p > 0.05) was found. In the same stimulus pattern, no statistically significant difference (n = 15, p > 0.05) between amblyopic eyes and fellow eyes was found in the amplitude and latency of P50 and N95 in the SA group. (4) P-ERG stimulated mode biased the magnocellular pathway: The amplitude and latency of P50 and N95 showed no statistically significant difference (p > 0.05) in either the AA group or the SA group. (5) We found no significant correlation between axial length and OCT, P-ERG parameters (p > 0.05) in either group. Conclusion Our results showed that the alterations in structure and function of retina that could be seen in adult anisometropic amblyopia were not found in adult strabismic amblyopia group. The functional loss in anisometropic amblyopia was found to bias to a damage of partial ganglion cells by the parvocellular pathway. These findings indicated that the pathological mechanisms were different between anisometropic and strabismic amblyopia.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Retinal Thickness and P-ERG Changes in Adult Patients With Anisometropic and Strabismic Amblyopia

Gao

Shao

et al. 2021

Preprint

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“…In their study conducted with 74 adults with anisometropic amblyopia and 78 healthy adults, Sahin et al found an increase in the thickness of the nasal RFNL and a decrease in the thickness of the temporal RNFL, similar to our present study 26 . This study, which found that RNFL was thicker in hypermetropic anisometropia groups in all quadrants and thinner in myopic anisometropia groups, may explain why the mean RNFL was found thicker in anisometropic and mixed amblyopia groups, and why there was no difference in the strabismic group in the present study, which included hypermetropic children specifically.…”

Section: Discussionsupporting

confidence: 91%

Evaluation of Retinal Nerve Fiber Layer Thickness and Macular Thickness in Amblyopic Children

Culha¹,

Arıcı²

2021

Cumhuriyet Medical Journal

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To compare central macular and retinal nerve fiber layer (RNFL) thickness using Spectral Domain Optical Coherence Tomography (SD-OCT) among patients with hyperopic anisometropic, strabismic and mixed amblyopia and healthy controls. Method: This prospective, cross-sectional study included 39 amblyopic children, their fellow eyes and 20 healthy individuals. Central macular and RNFL (superior, nasal, inferior and temporal quadrants and mean RNFL) thicknesses were measured with SD-OCT. Results: Difference was not statistically significant in the central macular thickness when the anisometropic, strabismic and mixed amblyopia groups were compared among themselves, fellow eyes and healthy control group. In the anisometropic amblyopic group, the inferior RNFL and nasal RNFL values were significantly thicker compared to the fellow eyes (p=0.009, p=0.028, respectively). Mean RNFL measurements were significantly thicker in anisometropic and mixed groups in the amblyopic eyes compared to the fellow eyes (p=0.009, p=0.031, respectively). In the temporal quadrant, the RNFL was found to be statistically significantly thinner in the anisometropic and mixed amblyopic groups compared to the fellow eyes (p=0.049, p=0.010, respectively). Conclusions:There was no considerably difference in the central macular thickness among the amblyopia groups, fellow eyes and healthy controls. However, significant changes were found in the mean RNFL and certain quadrants of the RNFL thicknesses in the anisometropic and mixed amblyopic groups.

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Evaluation of Bruch’s membrane opening-minimum rim width and retinal nerve fiber layer thickness in adults with anisometropic amblyopia

Celik

Köse

Çelik

et al. 2020

Photodiagnosis and Photodynamic Therapy

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Analysis of retinal nerve fiber layer thickness in anisometropic amblyopia via optic coherence tomography

Cited by 7 publications

References 57 publications

Retinal Thickness and P-ERG Changes in Adult Patients With Anisometropic and Strabismic Amblyopia

Retinal Thickness and P-ERG Changes in Adult Patients With Anisometropic and Strabismic Amblyopia

Evaluation of Retinal Nerve Fiber Layer Thickness and Macular Thickness in Amblyopic Children

Evaluation of Bruch’s membrane opening-minimum rim width and retinal nerve fiber layer thickness in adults with anisometropic amblyopia

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