Analysis of reticulin fiber pattern in lymph nodes with metastasis from oral squamous cell carcinoma

Yinti, Shanmukha Raviteja; Natarajan, Srikant; Boaz, Karen; Lewis, Amitha J; Pandya, Jay Ashokkumar; Kapila, Supriya Nikita

doi:10.4103/2155-8213.163814

Cited by 1 publication

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“…Indeed, invasive tumor growth in pancreatic ductal adenocarcinoma is mediated via matrix remodeling metalloproteinases (Croft et al, 2004;Rath et al, 2017). Changes in the fibrillar pattern of adjacent stroma of tumor tissues have been also observed in skin tumor (Stenbäck et al, 1999), oral squamous cell carcinoma, and lymph nodes with metastasis, among others (Yinti et al, 2015;Kardam et al, 2016). In fact, the tumor-derived extracellular matrix (ECM) is biochemically distinct in its composition and is stiffer than normal ECM.…”

Section: Introductionmentioning

confidence: 99%

Characterizing the Invasive Tumor Front of Aggressive Uterine Adenocarcinoma and Leiomyosarcoma

Sanegre

Eritja

Andrea

et al. 2021

Front. Cell Dev. Biol.

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The invasive tumor front (the tumor–host interface) is vitally important in malignant cell progression and metastasis. Tumor cell interactions with resident and infiltrating host cells and with the surrounding extracellular matrix and secreted factors ultimately determine the fate of the tumor. Herein we focus on the invasive tumor front, making an in-depth characterization of reticular fiber scaffolding, infiltrating immune cells, gene expression, and epigenetic profiles of classified aggressive primary uterine adenocarcinomas (24 patients) and leiomyosarcomas (11 patients). Sections of formalin-fixed samples before and after microdissection were scanned and studied. Reticular fiber architecture and immune cell infiltration were analyzed by automatized algorithms in colocalized regions of interest. Despite morphometric resemblance between reticular fibers and high presence of macrophages, we found some variance in other immune cell populations and distinctive gene expression and cell adhesion-related methylation signatures. Although no evident overall differences in immune response were detected at the gene expression and methylation level, impaired antimicrobial humoral response might be involved in uterine leiomyosarcoma spread. Similarities found at the invasive tumor front of uterine adenocarcinomas and leiomyosarcomas could facilitate the use of common biomarkers and therapies. Furthermore, molecular and architectural characterization of the invasive front of uterine malignancies may provide additional prognostic information beyond established prognostic factors.

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