Analysis of recurrent inhibitory circuit in rat thalamus: Neurophysiology of the thalamic reticular nucleus

Shosaku, Akira; Kayama, Yukihiko; Sumitomo, Ichiji; Sugitani, Michio; Iwama, Kitsuya

doi:10.1016/0301-0082(89)90011-7

Cited by 107 publications

(52 citation statements)

References 103 publications

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“…Ab, Application of bicuculline to the thalamocortical cell reveals the isolated GABA B component. Note that the latency of the response is longer for the activation of GABA B receptors than for (Figure legend continues) tors on thalamocortical cells (Thomson, 1988;Shosaku et al, 1989;Huguenard and Prince, 1994;Warren et al, 1994;Ulrich and Huguenard, 1995). The activation of C l Ϫ -dependent IPSPs and /or GABA A receptors is particularly prominent and important to the generation of spindle waves during slow wave sleep (Andersen and Sears, 1964;Deschênes et al, 1984;Bal et al, 1995a,b).…”

Section: Discussionmentioning

confidence: 99%

Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical NeuronsIn Vitro

Sánchez-Vives

McCormick

1997

J. Neurosci.

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The properties of the inhibitory influence of neurons in the perigeniculate (PGN) nucleus on thalamocortical cells were examined with intracellular recordings in the ferret geniculate slice maintained in vitro. Activation of PGN neurons with the local application of glutamate caused IPSPs in thalamocortical neurons that were mediated by both GABA A and GABA B receptors, as well as the activation of spindle waves.With low intensity stimulation of the PGN, local application of bicuculline to the dorsal lateral geniculate nucleus (LGNd) strongly inhibited evoked and spindle-associated IPSPs, indicating that these are largely mediated by GABA A receptors. The generation of GABA B receptor-mediated IPSPs in thalamocortical cells that were large enough to generate rebound low threshold Ca 2ϩ spikes required substantially increased activation of the PGN with glutamate.The activation of synchronous bicuculline-induced slowed oscillations in thalamocortical neurons required the block of GABA A receptors in the LGNd as well as in the PGN. These results indicate that bursts of action potentials in PGN neurons can result in the activation of both GABA A and GABA B receptors in thalamocortical neurons, with the strong activation of GABA B receptors requiring an intense, simultaneous discharge of a number of PGN neurons. Functionally, these results suggest that PGN neurons inhibit thalamocortical cells preferentially through the activation of GABA A receptors, although the strong activation of GABA B receptors may occur under pathological conditions and contribute to the generation of abnormal, synchronous slow oscillations.

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Section: Discussionmentioning

confidence: 99%

Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical NeuronsIn Vitro

Sánchez-Vives

McCormick

1997

J. Neurosci.

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“…But how do these auditory pathways relate to the nRT and how do they contribute to auditory gating in this thalamic region? Auditory gating has not been observed in the medial geniculate nucleus (Bickford-Wimer et al 1990;Shosaku et al 1989;Yingling and Skinner 1976) or in the auditory cortex (Moxon et al 1999). Thus, an involvement of these two main excitatory inputs to the nRT can be ruled out in the generation of a gated auditory response.…”

Section: Mechanisms Underlying Auditory Gating: Lemniscal Versus Nonlmentioning

confidence: 98%

Auditory sensory gating in hippocampus and reticular thalamic neurons in anesthetized rats

Krause¹,

Hoffmann²,

Hajós³

2003

Biological Psychiatry

119

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“…(As noted above, the collicular shifts are reported to develop rapidly while the cortical shifts develop slowly 25 , which seems incompatible with the model's principle that cortical plasticity induces collicular shifts.) Termination of the positive feedback loop, which ends the short-lived collicular plasticity, is hypothesized to be caused by inhibition from the thalamic reticular nucleus (TRS) (presumably at the level of the medial geniculate nucleus 53,54 ), which receives cholinergic input from the NB (Fig. 5b).…”

Section: Loci Of Plasticitymentioning

confidence: 99%

Specific long-term memory traces in primary auditory cortex

2004

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Learning and memory involve the storage of specific sensory experiences. However, until recently the idea that the primary sensory cortices could store specific memory traces had received little attention. Converging evidence obtained using techniques from sensory physiology and the neurobiology of learning and memory supports the idea that the primary auditory cortex acquires and retains specific memory traces about the behavioural significance of selected sounds. The cholinergic system of the nucleus basalis, when properly engaged, is sufficient to induce both specific memory traces and specific behavioural memory. A contemporary view of the primary auditory cortex should incorporate its mnemonic and other cognitive functions.Identifying the neural substrates of learning and memory is a core problem in neuroscience. As memories involve the representation of past sensory events, they may be stored, in part, within sensory systems. Sensory systems have traditionally been viewed as 'stimulus analysers', with learning and memory assigned to 'higher' cortical regions. Nonetheless, neurophysiological studies have produced evidence for learning-induced plasticity in sensory cortices, and in particular the auditory cortex. Galambos and colleagues first implicated the primary auditory cortex (A1) in learning in 1956, observing that pairing an auditory conditioned stimulus (CS) with a weak shock (a mildly aversive unconditioned stimulus (US)) produced a significant increase in the amplitude of CS-elicited evoked field potentials in A1 of the cat 1 . Subsequently, these findings were extended to other tasks (such as discrimination), types of learning (including instrumental conditioning), motivations (for example, food) and types of recording (such as single and multiple unit discharges) 2 .Although such results established associative plasticity in A1, neither they nor similar findings in other sensory cortices addressed the key issue of specificity of information storage. As memories have specific content, how could changes in the magnitude of sensory cortical responses adequately reflect the encoding of specific aspects of experiences? A solution was provided by the field of sensory neurophysiology, which focuses on stimulus specificity. Sensory physiology experiments use a wide range of stimulus values to NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript determine how specific sensory stimuli are processed and coded. In fact, the basic paradigms of sensory physiology and learning are complementary (Box 1).This article presents an overview of research that combines experimental designs from sensory physiology with those of learning and memory to search for specific memory traces in A1. A sign of a specific memory trace would be learning-induced physiological plasticity that has the key characteristics of behavioural memory and sufficient specificity to encode a canonical attribute of experience, such as a physical feature and its behavioural importance. Previous reviews have covered ot...

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Analysis of recurrent inhibitory circuit in rat thalamus: Neurophysiology of the thalamic reticular nucleus

Cited by 107 publications

References 103 publications

Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical NeuronsIn Vitro

Functional Properties of Perigeniculate Inhibition of Dorsal Lateral Geniculate Nucleus Thalamocortical NeuronsIn Vitro

Auditory sensory gating in hippocampus and reticular thalamic neurons in anesthetized rats

Specific long-term memory traces in primary auditory cortex

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