Analysis of recurrence of squamous cell carcinoma of the uterine cervix after definitive radiation therapy alone: patterns of recurrence, latent periods, and prognosis

Sakurai, Hideyuki; Mitsuhashi, Norio; Takahashi, Mitsuhiro; Akimoto, Tetsuo; Muramatsu, Hiroyuki; Ishikawa, Hitoshi; Imai, Reiko; Yamakawa, Michitaka; Hasegawa, Masatoshi; Niibe, Hideo

doi:10.1016/s0360-3016(01)01573-5

Cited by 46 publications

(40 citation statements)

References 23 publications

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“…Most recurrences are diagnosed during the first 1-2 years after initial treatment [3,15,20,22]. This fact is in accordance with our experience; we registered recurrences after a median time of 16 months following therapy of primary cancer.…”

Section: Discussionsupporting

confidence: 88%

Radiation Therapy and Simultaneous Chemotherapy for Recurrent Cervical Carcinoma

Windschall¹,

Ott²,

Sauer³

et al. 2005

Strahlenther Onkol

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Section: Discussionsupporting

confidence: 88%

Radiation Therapy and Simultaneous Chemotherapy for Recurrent Cervical Carcinoma

Windschall¹,

Ott²,

Sauer³

et al. 2005

Strahlenther Onkol

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“…Previous studies reported that late recurrence of cervical cancer after treatment often occurs with squamous cell carcinoma [13,15,16], higher stage [13,15], initial treatment by XRT [13][14][15][16] and lymph node metastasis [12,14]. However, these previous studies did not identify any independent risk factors for late recurrence, maybe because they were small studies with limited statistical power [13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

“…Over the past 4 decades, only a few studies have investigated late recurrence of cervical cancer [12][13][14][15]; thus, to justify long-term follow-up, more information on the incidence of late recurrence is required. Also, to our knowledge, no independent risk factors specific for late recurrence have been examined.…”

Section: Cervical Cancer · Radical Hysterectomy · Recurrence · Risk Fmentioning

confidence: 99%

Late Recurrence of Early Stage Cervical Cancer more than 3 Years after Radical Hysterectomy with Pelvic Node Dissection

Hanprasertpong¹,

Jiamset²

2017

Oncol Res Treat

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Background: The aim of this study was to compare the clinicopathological characteristics and outcomes of patients who developed late recurrence (> 3 years) of early stage cervical cancer after radical surgery with those of patients who developed early recurrence (≤ 3 years). We also investigated the risk factors of late recurrence. Methods: The records of 515 patients with early stage cervical cancer diagnosed between 1999 and 2015 were reviewed. 53 patients developed recurrence, 35 early and 18 late, and their clinicopathological characteristics and outcomes were compared. Of the 515 patients, the records for 307 patients who remained tumor free for at least 3 years after radical surgery were further examined. Results: No significant differences were found in clinicopathological characteristics and clinical outcomes between the early and late recurrence groups with regard to age, stage, histology, tumor size, lymphovascular space invasion, stromal invasion, parametrial involvement, node status, vaginal margin, preoperative blood testing, adjuvant therapy, symptom status at recurrence, site of recurrence and survival after recurrence. Late recurrence was detected in 18 of the 307 patients (5.9%). Only node status and deep stromal invasion (DSI) were independently associated with late recurrence. Conclusion: Lymph node metastasis and DSI are risk factors for late recurrence. Careful long-term follow-up is needed, particularly in cases with lymph node metastasis and/or DSI.

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“…In this case, fine needle aspiration cytology was realized two times to make an accurate diagnosis. This long latency period can be explained by late development of para-aortic or supraclavicular node metastasis after the initial treatment and the large volume represented by retroperitoneal space [12]. Thus, Narten et al [13] reported a case of a 66-year-old white woman which remained relatively asymptomatic for 26 years after radiation therapy for stage III squamous cell cervix carcinoma in which the diagnosis was made only at necropsy which revealed a large retroperitoneal mass.…”

Section: Discussionmentioning

confidence: 99%

Iliopsoas Metastasis from Cervix Carcinoma Masquerading as Psoas Abscess

Kamal¹,

Touiti²,

Jouhadi³

2012

JCST

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Objectives: Contribution of a case of unusual spread of cervical carcinoma mimicking iliopsoas abscess fifteen years after initial radiotherapy. Method:A 65-year-old white woman with history of squamous cell carcinoma of uterine cervix treated 15 years ago, was referred to our department with clinical and imaging's findings simulating a psoas abcess.Result: Colposcopy and punch biopsy confirmed the diagnosis of carcinoma of the cervix. Needle aspirate of cystic mass yielded a watery chocolate-colored. Cytopathology revealed cells suggestive of squamous cell carcinoma consistent with the diagnosis of metastasis from carcinoma cervix. Consultations with radiation therapy and medical oncology suggested no additional therapy .The patient became increasingly cachectic and died with generalized metastasis 3 months after admission. Conclusion:Through this case, the authors highlights the fact that metastasis from squamous cell carcinoma of the cervix can present as a psoas abscess and demonstrates certain difficulties in diagnosis even with the newer imaging modalities. Iliopsoas Metastasis from Cervix Carcinoma Masquerading as Psoas Abscess

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Analysis of recurrence of squamous cell carcinoma of the uterine cervix after definitive radiation therapy alone: patterns of recurrence, latent periods, and prognosis

Cited by 46 publications

References 23 publications

Radiation Therapy and Simultaneous Chemotherapy for Recurrent Cervical Carcinoma

Radiation Therapy and Simultaneous Chemotherapy for Recurrent Cervical Carcinoma

Late Recurrence of Early Stage Cervical Cancer more than 3 Years after Radical Hysterectomy with Pelvic Node Dissection

Iliopsoas Metastasis from Cervix Carcinoma Masquerading as Psoas Abscess

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