This article investigates the radiation properties of the wireless devices in nuclear power plants (NPPs) and proposes a new exclusion zone (EZ) with NPP indoor environment. The indoor EZs were affected by the multiple reflections, standing wave, and diffraction depending on the indoor geometry. To accurately analyze the variations between the indoor EZ and free-space EZ, multiple reflection ray tracing, modal analysis of a cylindrical coordinate, and measurements are performed. The results demonstrate that the proposed indoor EZ applied to the NPP environment is more practical and suitable than the EZ in free-space.