Analysis of Quality and Techniques for Hybridization of Medicinal Fungus Cordyceps sinensis (Berk.)Sacc. (Ascomycetes)

Holliday, John C.; Cleaver, Phillip D.; Loomis-Powers, Megan; Patel, Dinesh J.

doi:10.1615/intjmedmushr.v6.i2.60

Cited by 50 publications

(28 citation statements)

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“…In TCM, cordyceps has always been revered. The increase in its popularity has led to over-harvesting and subsequent scarcity of wild species (Holliday, Cleaver, Megan, & Patel, 2004;Hsu, Shiao, Hsiea, & Chang, 2002). Convention on International Trade in Endangered Species (CITES) Management Authority of China has officially classified this fungus as an endangered species (CITES Management Authority of China, 2012).…”

Section: Introductionmentioning

confidence: 99%

“…Convention on International Trade in Endangered Species (CITES) Management Authority of China has officially classified this fungus as an endangered species (CITES Management Authority of China, 2012). Further, researchers looked forward to cultivate this species on artificial medium and by mid-1990's, artificially cultivated CS are marketed all over the world (Holliday et al, 2004; Miz- uno, 1999). Promising methods like bioreactor cultivating technology have been followed to cultivate isolated living strains from natural CS to meet human needs and to reduce the pressure on natural resources of the species (Dong & Yao, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Shashidhar

Giridhar

Sankar

et al. 2013

Journal of Functional Foods

102

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Extraction Health benefits A B S T R A C T Cordyceps sinensis (CS) is a well-known entamophagus fungus, naturally distributed in the Tibetan Plateau of Asia and Himalayas. Recently this synonym is transferred to Ophiocordyceps by both scientific and non-scientific communities. It is widely used as a tonic and medicinal food in traditional Chinese medicine (TCM), as it possess wonderful health benefits. To support its functional attributes, various investigations have been carried out to find out its adaptogenic, aphrodisiac, anti-oxidant, anti-aging, neuroprotective, nootropic, immunomodulatory, anti-cancer and hepatoprotective role. Its fruiting portion as well as the larvae possesses potent bio-active fractions and their composition almost found to be similar in both. The bioactive principles are nucleosides, exo-polysaccharides, sterols and, proteins, among others. Among nucleosides, adenosine and cordycepin are the major biochemical markers. Further, different types of solvent extracts and their mixtures exhibit wide range of pharmacological activities, while the water and methanol extracts with the richest sources of nucleosides and polysaccharides also show wide range of pharmacological activities. This review gives a panoramic view of potential health benefits of various classes of bio-active fractions along with the need for sustainable management of CS for human wellness.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Shashidhar

Giridhar

Sankar

et al. 2013

Journal of Functional Foods

102

View full text Add to dashboard Cite

show abstract

“…In many cases, the solid substrate‐grown mycelia tested contained greater than 80% residual grain. The amount of soya bean residual substrate in the finished product could be as high as at 90–99% (Holliday et al,2004). For the unknown plant structure in sample 1 of fermented Cordyceps , it may be the residue of substrates such as millet, white milo, rye, and wheat, which are commonly used as substrate compositions (Holliday et al,2004).…”

Section: Resultsmentioning

confidence: 99%

Application of microscopy in authentication of valuable Chinese medicine i—Cordyceps sinensis, its counterfeits, and related products

Wang

Yang

et al. 2012

Microscopy Res & Technique

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Light and polarized microscope was applied to authenticate 32 Cordyceps and 6 artificial counterfeits and 8 fermented Cordyceps as well as 7 Cordyceps capsules available in Hong Kong markets. Results showed that transverse sections of stroma and powder of larvae can be used to differentiate C. sinensis from its counterfeits. The fermented Cordyceps are in powder form. Among the eight fermented Cordyceps collected, half of them were pure; three were a mixture of fermented Cordyceps and soya beans; one was a mixture of unknown plant tissues and soya beans. For the seven Cordyceps capsules, the powders of five samples were a mixture of fermented Cordyceps and soya beans; the powders of other two were a mixture of C. sinensis stroma powder and fermented Cordyceps. The study indicated that the microscopy is an unambiguous method that requests fewer sample for the authentication of valuable Chinese medicine-C. sinensis and its related products.

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“…[7,8,12,14,15,24,39,48,52,66,67,83,92,98,107,121,136,140,161,162,167,173,177,178,180,188,194,200,207,208,[210][211][212]. [164].…”

Section: 배지 균사체 및 자실체 생산mentioning

confidence: 99%

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

Lee¹,

Kim²,

Park³

et al. 2017

Journal of Life Science

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Cordyceps is a traditional Chinese medicinal herb well-known in China, Korea and Japan since B.C. 2,000. The original entomopathogenic fungus, Cordyceps sinensis belonging to the genus Cordyceps could not be found inside Korean peninsula due to the absence of the host insect for the corresponding entomogenous fungus. The development of artificial production methods of Korean type Cordyceps using the silkworm Bombyx mori as in vivo culture medium for the the entomopathogenic fungus Paecilomyces tenuipes is the first, and wonderful occasion in the research history of insect industry of this global world. The aim of this article is to review the historical research background, mass-production methods, and pharmacological effects of the silkworm-dongchunghacho (Paecilomyces tenuipes) which is a newly developed Korean medicinal insect-borne mushroom, and another non-insect-borne medicinal mushroom (Cordyceps militaris and Cordyceps pruinosa). Their biological actions include anti-tumor, immunostimulating, anti-fatigue, anti-stress, anti-oxidant, anti-aging, anti-diabetic, anti-inflammatory, anti-thrombosis, hypolipidaemic and insecticidal effects. The bioactive principles are protein-bound polysaccharides (hexose, hexosamin), cordycepin, D-manitol, acidic polysaccharide etc. Protein-bound polysaccharides and n-butanol fractions were demonstrated to show a significant anti-tumor activities but did not show a cytotoxicities. D-mannitol exhibited a significant prolongation of the life span in tumor bearing mice. Ergosterol did not show an efficient anti-tumor activity, but showed a significant phagocytosis enhancing activity. Anti-tumor activity of silkworm-dongchunghacho might be attributed to immuno-stimulating activities rather than cytotoxic effects [164]. Also this review comprises the breeding of Dongchunghacho varieties, optimization of culture conditions, improvement of learning and memory by Dongchunghacho, application of them as foods and chemical constituents.

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Analysis of Quality and Techniques for Hybridization of Medicinal Fungus Cordyceps sinensis (Berk.)Sacc. (Ascomycetes)

Cited by 50 publications

References 0 publications

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Bioactive principles from Cordyceps sinensis: A potent food supplement – A review

Application of microscopy in authentication of valuable Chinese medicine i—Cordyceps sinensis, its counterfeits, and related products

Properties of the Silkworm (Bombyx mori) Dongchunghacho, a Newly Developed Korean Medicinal Insect-borne Mushroom: Mass-production and Pharmacological Actions

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