Analysis of pseudoprogression after proton or photon therapy of 99 patients with low grade and anaplastic glioma

Abstract

HighlightsNo difference in pseudoprogression rate six months after proton or photon therapy.Oligodendrogliomas develop pseudoprogression sooner after protons vs. photons.Astrocytomas develop pseudoprogression at similar time after protons vs. photons.

Pseudoprogression after radiation therapies for low grade glioma in children and adults: A systematic review and meta-analysis

“…After the removal of 214 duplicate articles, the title and abstract of the remaining 300 articles were evaluated against the selection criteria. Full-text analysis was performed for 18 articles, in which 9 retrospective observational cohort studies were assessed to satisfy all selection criteria for quantitative analysis, 5 studies [26][27][28][29][30] describing outcomes of pediatric LGG, and another 4 studies [15,[31][32][33] describing outcomes of adult LGG ( Table 1). Definitions of PsP by each study are included in Table 2.…”

“…The 4 adult LGG studies [15,[31][32][33] described the PsP outcomes of 424 subjects, where 271 (64%) were treated with IMRT, and 153 (36%) were treated with PBT (Table 1). Median age ranged from 37 to 45 years old with proportion of female subjects ranging from 30% to 53% and median follow-up ranging from 0.5 to 6 years.…”

“…In adult LGGs treated by any type of radiation therapy, the incidence of PsP was 22% (95% CI, 15-29%; I 2 = 49%; P-heterogeneity = 0.11). In those LGGs treated by IMRT (3 cohort studies [15,32,33]; n = 140 subjects), the incidence of PsP was estimated to be 18% (95% CI, 12-25%; I 2 = NA) by RE modelling (Fig. 3).…”

Perfusion MRI in treatment evaluation of glioblastomas: Clinical relevance of current and future techniques

“…Pseudoprogression can also be caused by proton therapy. A recent study among high‐grade gliomas showed similar incidences of pseudoprogression between conventionally irradiated patients and patients receiving proton therapy . However, little is known about pseudoprogression and the role of perfusion MRI for treatment follow‐up in GBM patients treated with proton beam therapy.…”

Influence of Therapeutic Proton Beam on Glioblastoma Multiforme Proliferation Index — A Preliminary Study

“…Numerous in vitro radiobiological studies for various cells using protons and photons have been carried out resulting in controversial data [21]. Authors showed that results are strongly influenced by the type of cells, culture condition, dose, dose rate, fractionation, and other physical features (i.e., LET, RBE) [22].…”