Abstract:One characteristic of human cytomegalovirus (HCMV) is the high complexity of its genome: the double-stranded DNA of approx 240 kbp contains the coding capacity for more than 200 different proteins (1,2). The genes encoding those proteins are expressed coordinately during the replication of this virus (3). Although posttranscriptional regulation has been described for HCMV, transcriptional regulation by promoter activation is believed to play a key role in mediating the cascade fashion of gene expression observ… Show more
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