Analysis of Promethazine Hydrochloride in Syrups

Sperling, Albert R.

doi:10.1002/jps.2600560120

Cited by 7 publications

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“…Phenothiazine drugs are currently formulated in a variety of dosage forms either as the sole medicament or in combination with one or more other drugs. Among the methods used to assay the phenothiazine drugs in pharmaceutical preparations are titrimetric (Soliman, Abdine & Zakhari, 1975), chromatographic (Sperling, 1967;Smith, 1972), ultraviolet (Flanagan, Lin & others, 1959) and visible spectrophotometric procedures (Ryan, 1959;Murty & Baxter, 1970).…”

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confidence: 99%

The determination of phenothiazine drugs in pharmaceutical preparations by a difference spectrophotometric method

Davidson

1976

Journal of Pharmacy and Pharmacology

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A method is described for the rapid determination of phenothiazine drugs in a wide variety of pharmaceutical preparations. The drugs are determined by a difference spectrophotometric technique based upon the absorbance of the sulphoxide derivative of the drug relative to the absorbance of a solution of the underivatized drug. The sulphoxide derivatives are formed rapidly and quantitatively at room temperature by the addition of a solution of peroxyacetic acid, prepared by the slow reaction of hydrogen peroxide and glacial acetic acid on standing. The difference absorbance of the solutions is proportional to the concentration of the phenothiazine drug in the preparation and is specific for the intact drug in the presence of oxidative and photochemical decomposition products, colouring and flavouring agents, excipients and most co-formulated drugs.

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confidence: 99%