Analysis of prognostic factors and treatment of anaplastic meningioma in China

Zhu, Hongda; Xie, Qing; Zhou, Yu; Chen, Hong; Mao, Ying; Zhong, Ping; Zheng, Kewen; Wang, Yongfei; Wang, Yin; Xie, Lihui; Zheng, Mingzhe; Wang, Daijun; Chen, Xiancheng; Zhou, Lei; Gong, Yi

doi:10.1016/j.jocn.2014.10.023

Cited by 27 publications

(18 citation statements)

References 23 publications

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“…However, the effect of age and preoperative KPS on PFS and OS was not observed in our study and other reports (10)(11)(12). Although female was considered as one of the risk factors of benign meningiomas, gender differences was not found in malignant meningiomas (14)(15)(16). In contrast, a slight female predominance (a male to female ratio of 1:1.4) is observed in our study.…”

Section: Discussioncontrasting

confidence: 94%

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Analysis of Prognostic Factors of World Health Organization Grade Ⅲ Meningiomas

et al. 2020

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ObjectiveWHO grade III meningiomas are highly aggressive and lethal. However, there is a paucity of clinical information because of a low incidence rate, and little is known for prognostic factors. The aim of this work is to analyze clinical characteristics and prognosis in patients diagnosed as WHO grade III meningiomas.Methods36 patients with WHO grade III meningiomas were enrolled in this study. Data on gender, age, clinical presentation, preoperative Karnofsky Performance Status (KPS), histopathologic features, tumor size, location, radiologic findings, postoperative radiotherapy (RT), surgical treatment, and prognosis were retrospectively analyzed. Progression-free survival (PFS) and overall survival (OS) were evaluated using the Kaplan-Meier method. Univariate and multivariate analysis were conducted by the Cox regression model.ResultsMedian PFS is 20 months and median OS is 36 months in 36 patients with WHO grade III meningiomas. Patients with secondary tumors which transformed from low grade meningomas had lower PFS (p=0.0014) compared with primary group. Multivariate analysis revealed that tumors location (PFS, p=0.016; OS, p=0.013), Ki-67 index (PFS, p=0.004; OS, p<0.001) and postoperative radiotherapy (PFS, p=0.006; OS, p<0.001) were associated with prognosis.ConclusionWHO grade III meningiomas which progressed from low grade meningiomas were more prone to have recurrences or progression. Tumors location and Ki-67 index can be employed to predict patient outcomes. Adjuvant radiotherapy after surgery can significantly improve patient prognosis.

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Section: Discussioncontrasting

confidence: 94%

“…Several WHO grade III meningiomas can progress from benign or atypical meningiomas (WHO grade I/II) (15,16,19). Comparison between primary group and secondary group is performed in this study.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Prognostic Factors of World Health Organization Grade Ⅲ Meningiomas

et al. 2020

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“…It appears that the majority of neurosurgeons would refer patients with partially resected MM to RT [31,32,34,35,57,58]. As described earlier, both the rarity of these tumors and the smaller degree of equipoise add to a very limited data pool about the efficacy of radiation for MM.…”

Section: Radiation For Who Grade III Meningiomamentioning

confidence: 99%

“…A recent single center publication from China found 63 patients who had surgery for MM between 2003 and 2008 [37]. Univariate analysis demonstrated a potential correlation between EOR and PFS.…”

Section: Extent Of Resection -Who Grade III Meningiomamentioning

confidence: 99%

Review of controversies in management of non-benign meningioma

Paldor

Awad

Sufaro

et al. 2016

Journal of Clinical Neuroscience

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“…3 While grade III meningiomas are rare and represent 1%-2% of all meningiomas, 4 they are characterized by significant morbidity and mortality, with a reported median overall survival (OS) ranging from 2.6 to 5.8 years. [5][6][7][8][9][10] WHO grade III meningiomas are defined by a mitotic index equal to or greater than 20 mitoses per 10 high power fields (HPF; 1.6 mm 2 ), and/or overt anaplasia (loss of meningothelial differentiation associated with pseudo-carcinomatous, -sarcomatous, or -melanomatous features), and/or papillary variants. 11 Rhabdoid meningiomas sometimes lack overt features of malignancy and may follow a benign clinical course, even if rhabdoid features are well developed and extensive throughout the tumor, 12 and were therefore excluded from this study.…”

mentioning

confidence: 99%