“…APCI ionizes analytes by the molecule-ion reaction or electronion reaction under negative pressure. 20 Its characteristics are suitable for analyzing gaseous samples, APCI-MS has been used widely in analyses of food-avoring composition, [21][22][23] exhaledgas detection, 24 environmental pollution, 25 as well as monitoring of volatile organic pollutants 26,27 and chemical warfare agents. 28 The application range of technology based on a single ionization source is constrained by the characteristics of the ionization source and polarity of the target object.…”