Analysis of predictive parameters for the development of radiation-induced pneumonitis

Yamagishi, Toshiyuki; Kodaka, Norio; Kurose, Yoshiyuki; Watanabe, Kazuo; Nakano, Chihiro; Kishimoto, Kenji; Oshio, Takeshi; Niitsuma, Kumiko; Matsuse, Hiroto

doi:10.4103/atm.atm_355_16

Cited by 4 publications

(1 citation statement)

References 37 publications

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“…Lymphocyte fractions in bronchi alveolar lavage fluid increased significantly at 1 month after radiotherapy of the lung cancer patients with RP. 27 While the hypersensitivity reaction mediated by radiotherapy was elucidated, the immunosuppressive effects are becoming better explored. Radiotherapy was often accompanied by lymphopenia because of the high radiosensitivity of circulating lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors

Zhang¹,

Yang²,

Jiang³

et al. 2021

JIR

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Purpose We sought to compare the symptomatic radiation pneumonitis (RP) in lung cancer patients treated with helical tomotherapy (HT) versus intensity-modulated radiotherapy (IMRT), and examine the predictive value of circulating lymphocyte subsets affecting the occurrence of RP. Patients and Methods Circulating lymphocyte subsets, clinical characteristics, dosimetric parameters and pulmonary function were collected from 130 lung cancer patients treated with HT (n = 53) or IMRT (n = 77) from 2016 through 2020. Symptomatic RP was compared between groups. Binary logistic regression was used to identify predictors of RP. Results The IMRT group had larger planning target volume (319.9 vs 240.8 cc, P = 0.041); more ECOG performance status 0–1 (96.1% vs 79.2%, P = 0.002); more stage III–IV disease (94.8% vs 37.6%, P = 0.028); and more combined systemic therapy (85.7% vs 69.8%, P = 0.022). Grade ≥2 RP were comparable between IMRT and HT groups (16.9% vs 15.1%, P = 0.785). For stage III–IV disease, IMRT was associated with lower lung V10 (31.9% vs 35.8%, P = 0.047) and lower incidence of grade 5 RP (0% vs 9.1%, P = 0.018). All lymphocyte subsets reduced after radiotherapy. The decrease degree of total T cell count and CD4 + T cell count were larger after IMRT than HT (P = 0.043, P = 0.021). In univariate analysis, the smoking status, lower baseline FEV1, and higher total T cell count, higher CD8 + T cell count, lower total B cell count, lower CD4 + /CD8 + ratio after radiotherapy were associated with the development of grade ≥2 RP. The higher CD8 + T cell count after radiotherapy was the only risk factor associated with grade ≥2 RP in multivariable analysis (OR 1.003; 95% CI: 1.000–1.005; P = 0.044). Conclusion IMRT was associated with lower lung V10 and less grade 5 RP than HT for stage III–IV lung cancer. Higher CD8 + T cell count after radiotherapy was associated with an increased risk of RP. HT may better preserve total T cell and CD4 + T cell than IMRT.

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Section: Discussionmentioning

confidence: 99%

Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors

Zhang¹,

Yang²,

Jiang³

et al. 2021

JIR

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Research Progress of Risk Factors Related to Radiation Pneumonitis

白¹

2022

ACM

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Bronchoalveolar Lavage Fluid-Isolated Biomarkers for the Diagnostic and Prognostic Assessment of Lung Cancer

et al. 2022

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Lung cancer is considered one of the most fatal malignant neoplasms because of its late detection. Detecting molecular markers in samples from routine bronchoscopy, including many liquid-based cytology procedures, such as bronchoalveolar lavage fluid (BALF), could serve as a favorable technique to enhance the efficiency of a lung cancer diagnosis. BALF analysis is a promising approach to evaluating the tumor progression microenvironment. BALF’s cellular and non-cellular components dictate the inflammatory response in a cancer-proliferating microenvironment. Furthermore, it is an essential material for detecting clinically significant predictive and prognostic biomarkers that may aid in guiding treatment choices and evaluating therapy-induced toxicities in lung cancer. In the present article, we have reviewed recent literature about the utility of BALF analysis for detecting markers in different stages of tumor cell metabolism, employing either specific biomarker assays or broader omics approaches.

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Analysis of predictive parameters for the development of radiation-induced pneumonitis

Cited by 4 publications

References 37 publications

Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors

Comparison of Radiation Pneumonitis in Lung Cancer Patients Treated with HT versus IMRT and Circulating Lymphocyte Subsets as Predicting Risk Factors

Research Progress of Risk Factors Related to Radiation Pneumonitis

Bronchoalveolar Lavage Fluid-Isolated Biomarkers for the Diagnostic and Prognostic Assessment of Lung Cancer

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