Analysis of Predictive Model of Coronary Vulnerable Plaque under Hemodynamic Numerical Simulation

Abstract

Objective. Vulnerable plaque is considered to be the cause of most clinical coronary arteries, and linear cytokines are an important factor causing plaque instability. Early prediction of vulnerable plaque is of great significance in the treatment of cardiovascular diseases. Methods. Computational fluid dynamics (CFD) was used to simulate the hemodynamics around plaques, and the serum biochemical markers in 224 patients with low-risk acute coronary syndrome (ACS) were analyzed. Vulnerable plaques were predicted according to the distribution of biochemical markers in serum. Results. CFD can accurately capture the hemodynamic characteristics around the plaque. The patient’s age, history of hyperlipidemia, apolipoprotein B (apoB), adiponectin (ADP), and sE-Selection were risk factors for vulnerable plaque. Area under curve (AUC) values corresponding to the five biochemical markers were 0.601, 0.523, 0.562, 0.519, 0.539, and the AUC value after the combination of the five indicators was 0.826. Conclusion. The combination of multiple biochemical markers to predict vulnerable plaque was of high diagnostic value, and this method was convenient and noninvasive, which was worthy of clinical promotion.

CT Coronary Angiography: Technical Approach and Atherosclerotic Plaque Characterization

“…Additionally, computational fluid dynamics (CFD) has been used with promising results to simulate the hemodynamics around plaques [106].…”

Time-resolved simulation of blood flow through left anterior descending coronary artery: effect of varying extent of stenosis on hemodynamics

“…Currently, most studies mainly focus on the destruction and changes of endothelial cells in coronary stenotic vessels due to physical factors under different flow fields and action time [ 10 – 15 ], which could provide a rich theoretical basis for exploring the pathological mechanism of atherosclerosis formation and its development. Moreover, current research reveals that coronary atherosclerosis is also the process of the local narrowing of coronary arteries, and that its stenosis lesion enables the significant changes of the geometry and physiological properties of coronary arteries, the cause of the alteration in blood flow pattern and flow field simultaneously, and the induction of the proliferation of endothelial tissue, which would promote further stenosis of coronary arteries and the aggravation of atherosclerosis, thus leading to serious circulatory diseases [ 15 – 21 ].…”

Retracted: Analysis of Predictive Model of Coronary Vulnerable Plaque under Hemodynamic Numerical Simulation

“…This article has been retracted by Hindawi, as publisher, following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of systematic manipulation of the publication and peer-review process.…”