Analysis of Pre-Erythrocytic Immunity During Plasmodium Vivax Infection Reveals a Diversity of Responses That is Partially Due to Blood Stage Cross-Reactivity
Abstract:BackgroundPlasmodium vivax (Pv) represents the most geographically widespread human malaria parasite. Targeting the pre-erythrocytic (PE) stage of the parasite life cycle is especially appealing for Pv vaccines as it would prevent disease and transmission. Here, we explore naturally acquired immunity to a panel of Pv PE antigens as a first step to enable vaccine development and to better understand naturally-acquired PE immunity.MethodsHumoral and cellular immunity were evaluated by ELISA and ELISpot, using sa… Show more
“…[108][109][110][111][112] However, a manuscript in preprint at the time of this review suggests that a non-human primate model of Pv blood stage infection may be near and thus could fill a significant gap in the preclinical assessment of Pv blood stage mAbs. 113…”
“…[108][109][110][111][112] However, a manuscript in preprint at the time of this review suggests that a non-human primate model of Pv blood stage infection may be near and thus could fill a significant gap in the preclinical assessment of Pv blood stage mAbs. 113…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.