Analysis of polyphenolic compounds and radical scavenging activity of four American <i>Actaea</i> species

Nuntanakorn, Paiboon; Jiang, Bei; Yang, Hui; Cervantes‐Cervantes, Miguel; Kronenberg, Fredi; Kennelly, Edward J.

doi:10.1002/pca.975

Cited by 27 publications

(34 citation statements)

References 29 publications

(38 reference statements)

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“…The HPLC-UV fingerprint of them has been used to distinguish A. racemosa from major American and Asian Actaea species [11, 21]. The current study demonstrated that the EIC profile in MS positive mode of these five hydroxycinnamic acid esters could also distinguish A. racemosa from the other two American species and two Asian adulterants successfully, as shown in Fig.…”

Section: Resultssupporting

confidence: 53%

“…Despite increasing consumption and extensive investigation, the mechanisms of its alleviation of climacteric symptoms remain largely undefined [9–11]. The phytochemical constitution of black cohosh is complex and the active ingredients remain unknown.…”

Section: Introductionmentioning

confidence: 99%

“…Profile analysis of phenolics and triterpenes using HPLC-UV, HPLC-MS and HPLC-ELSD (evaporative light scattering detection) have been successfully applied to distinguish A. racemosa from other American (i.e. A. pachypoda , A. podocarpa , and A. rubra ), and Asian Actaea species [11, 14–17]. These profiling methods relied on the identification and comparison of chromatographic patterns of the complex components between Actaea species, which are not easy to perform routinely.…”

Section: Introductionmentioning

confidence: 99%

“…The previous work of ours [19, 20] and other researchers [6, 8, 11, 14, 16, 18, 21–23] on black cohosh components focused primarily on: 1) using ESI-negative mode to detect phenolic acids and phenolic esters; 2) using ESI/APCI-positive mode to detect triterpenes. In order to explore useful information that may be neglected in the MS positive data, principle component analysis (PCA) was performed on positive data (especially compounds eluted ahead of triterpenes on reverse phase column) in this study.…”

Section: Introductionmentioning

confidence: 99%

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Feruloyl dopamine-O-hexosides are efficient marker compounds as orthogonal validation for authentication of black cohosh (Actaea racemosa)—an UHPLC-HRAM-MS chemometrics study

et al. 2017

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Due to the complexity and variation of the chemical constituents in authentic black cohosh (Actaea racemosa) and its potential adulterant species, an accurate and feasible method for black cohosh authentication is not easy. A high resolution accurate mass (HRAM) LC-MS fingerprinting method combined with chemometric approach was employed to discover new marker compounds. Seven hydroxycinnamic acid amide (HCAA) glycosides are proposed as potential marker compounds for differentiation of black cohosh from related species, including two Asian species (A. foetida, A. dahurica) and two American species (A. pachypoda, A. podocarpa). These markers were putatively identified by comparing their mass spectral fragmentation behavior with those of their authentic aglycone compounds and phytochemistry reports. Two isomers of feruloyl methyldopamine 4-O-hexoside ([M+H]+ 506) and one feruloyl tyramine 4-O-hexoside ([M+H]+ 476) contributed significantly to the separation of Asian species in principle component analysis (PCA) score plot. The efficacy of the models built on four reasonable combinations of these markers in differentiating black cohosh and its adulterants were evaluated and validated by partial least-square discriminant analysis (PLS-DA). Two models based on these reduced dataset achieved 100% accuracy based on the current sample collection, including the model that used only three feruloyl dopamine-O-hexoside isomers ([M+H]+ 492) and one feruloyl dopamine-O-dihexoside ([M+H-hexosyl]+ at m/z 492).

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Section: Resultssupporting

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Feruloyl dopamine-O-hexosides are efficient marker compounds as orthogonal validation for authentication of black cohosh (Actaea racemosa)—an UHPLC-HRAM-MS chemometrics study

et al. 2017

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“…[30] A similar method for isolating CGA has been reported for flowers of L. japonica (honeysuckle) using HPD-850 chromatography. [16] Following elution with 70% ethanol, the CGA content of the honeysuckle extract increased 4.5 fold.…”

Section: Resultsmentioning

confidence: 99%

Standardised herbal extract of chlorogenic acid from leaves of Etlingera elatior (Zingiberaceae)

Chan¹,

Lim²,

Tan³

2011

Phcog Res

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Background:Chlorogenic acid (CGA) or 5-caffeoylquinic acid, was found to be the dominant phenolic compound in leaves of Etlingera elatior (Zingiberaceae). The CGA content of E. elatior leaves was significantly higher than flowers of Lonicera japonica (honeysuckle), the commercial source. In this study, a protocol to produce a standardised herbal CGA extract from leaves of E. elatior using column chromatography was developed.Materials and Methods:Freeze-dried leaves of E. elatior were extracted with 30% ethanol, and sequentially fractionated using Diaion HP-20 and Sephadex LH-20.Results:The CGA fractions, which yielded extracts of 10% and 40% w/w purity, possessed antioxidant, tyrosinase inhibition, and antibacterial properties. The entire fractionation process took only 6.5 hours, using gravity flow. From 50 g of leaves, the final yield of CGA extract was 0.2 g (0.4%). The CGA content of the standardised herbal extract from leaves of E. elatior (40%) is 1.6 times that of commercial extracts from honeysuckle flowers (25%).Conclusion:With high CGA content, the standardised herbal extract has a great potential to be developed into functional food and other health products. Leaves of E. elatior, which currently have no economic value, could serve as an alternative source of CGA. Leaves are large, available in abundance, and harvesting is non-destructive to the plants.

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Red Baneberry [ Actaea rubra (Aiton) Willd.]

Barceloux

2008

Medical Toxicology of Natural Substances

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Analysis of polyphenolic compounds and radical scavenging activity of four American Actaea species

Cited by 27 publications

References 29 publications

Feruloyl dopamine-O-hexosides are efficient marker compounds as orthogonal validation for authentication of black cohosh (Actaea racemosa)—an UHPLC-HRAM-MS chemometrics study

Feruloyl dopamine-O-hexosides are efficient marker compounds as orthogonal validation for authentication of black cohosh (Actaea racemosa)—an UHPLC-HRAM-MS chemometrics study

Standardised herbal extract of chlorogenic acid from leaves of Etlingera elatior (Zingiberaceae)

Red Baneberry [ Actaea rubra (Aiton) Willd.]

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