Analysis of polymorphism of bone metabolism genes and evaluation of the risk of osteopenia in cosmonauts

Оганов, В. С.; Baranov, V. S.; Kabitskaya, O. E.; Novikov, V. V.; Бакулин, А. В.; Москаленко, М. В.; Асеев, М. В.; Voitulevich, L. V.

doi:10.1134/s0362119712070183

Cited by 3 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On these bases, the authors conclude that gravity affects the response of Runx2 to Vit D3. These results are in keeping with a recent report showing that a rapid decrease of bone mineral density correlated with polymorphisms for the genes of VDR and of collagen, type I, alpha 1 (Col1a1) in the majority of cosmonauts [ 51 ].…”

Section: Considerations Concerning Approaches and Modelssupporting

confidence: 92%

Stem Cells toward the Future: The Space Challenge

Bradamante

Barenghi

Maier

2014

Life

View full text Add to dashboard Cite

Astronauts experience weightlessness-induced bone loss due to an unbalanced process of bone remodeling that involves bone mesenchymal stem cells (bMSCs), as well as osteoblasts, osteocytes, and osteoclasts. The effects of microgravity on osteo-cells have been extensively studied, but it is only recently that consideration has been given to the role of bone MSCs. These live in adult bone marrow niches, are characterized by their self-renewal and multipotent differentiation capacities, and the published data indicate that they may lead to interesting returns in the biomedical/bioengineering fields. This review describes the published findings concerning bMSCs exposed to simulated/real microgravity, mainly concentrating on how mechanosignaling, mechanotransduction and oxygen influence their proliferation, senescence and differentiation. A comprehensive understanding of bMSC behavior in microgravity and their role in preventing bone loss will be essential for entering the future age of long-lasting, manned space exploration.

show abstract

Section: Considerations Concerning Approaches and Modelssupporting

confidence: 92%

Stem Cells toward the Future: The Space Challenge

Bradamante

Barenghi

Maier

2014

Life

View full text Add to dashboard Cite

show abstract

“…Similar alterations in VDR expression are described in femurs harvested from a hind-limb unloading experiment (Xin et al, 2015) and in bone and renal cells exposed to microgravity (Hammond et al, 2000;Narayanan et al, 2002;Xin et al, 2015). Furthermore, a correlation between osteoporosis and polymorphism of VDR genes has been identified in cosmonauts returning to earth after an extended stay on the orbital stations (Oganov et al, 2010). Interestingly, over the past decades, significant…”

Section: Effect Of Hg On Temporal Distribution Of Tumor Protein P53mentioning

confidence: 55%

Impact of g-Load Shift on Temporal Expression Pattern of Apoptosis-linked Proteins in the Rat Mammary Gland

Alula

Resau

Patel

2019

Gravitational and Space Research

View full text Add to dashboard Cite

Alteration in gravitational load impacts homeorhetic response in rat dams which affects neonatal pup survival. However, the effects of hypergravity (HG) exposure on the abundance of apoptosis-associated proteins in mammary epithelial cells (MECs) have not been characterized. Therefore, we examined whether chronic exposure to HG from midpregnancy alters the abundance of proapoptotic proteins in MECs during the late pregnancy and early lactation. A group of pregnant Sprague Dawley rats were exposed to either HG (2g) or normo-gravity (1g: stationary control [SC]) from days 11 to 20 of gestation (G20). Another set of animals were investigated from day 11 of pregnancy through days 1 and 3 (P1 and P3, respectively) postpartum. Quantitative (pixels [px]/lobule) immunohistochemistry at G20 of Cleaved Caspase-3 (CC-3), Tumor Protein p53 (P53), and vitamin D receptor (VDR) revealed that all the three proteins were increased (p<0.01) in HG rats compared to SC animals. At P1, the HG group had twofold higher (p<0.001) expression of CC-3 relative to the SC group. Approximately, 50% (p<0.001) more VDR was detected in the HG cohorts than SC at P3. These results suggest that a shift in g-load upregulates the expression of key proapoptotic proteins during the pregnancy-to-lactation transition in the rat MECs.

show abstract

“…We demonstrated, in particular, that, in the main group of cosmonauts, rapid loss of BM is corre lated with the TT genotype for the gene of vitamin D receptor (VDR), as compared with cosmonauts with the Tt and tt genotypes; it is also associated with the deficient s allele of the collagen gene (Cola1) [6].…”

Section: Resultsmentioning

confidence: 97%

Characteristics of local human skeleton responses to microgravity and drug treatment for osteoporosis in clinic

et al. 2014

Self Cite

View full text Add to dashboard Cite

762The bony skeleton of ground animals, its mass, the shapes of individual elements of the bone system, macrostructure of bone tissue and its microarchitec tonics-all this in general is nothing but manifestation of "gravitational memory" and structural trace left by millions of years of evolution of living systems in Earth's gravitational field.Retrospective analysis of studies in evolutionary and comparative physiology [3,9] confirms the dependence of specific mass of skeleton of ground ani mals on the sizes and mass of their body (the Galilei principle of similitude) and its absence in inhabitants of aquatic medium, where the buoyancy force coun teracts Earth's gravitation force. In other words, dependence of bone mass of the human skeleton on the magnitude and constancy of its mechanical stimu lation is predetermined evolutionarily.It is conventional to name morphological and physiological modifications of tissues and organs in adult animals arising from the effect of functional mechanical demands at body interaction with the environment "functional adaptation" [11]. Hence, even at early stages of preparation of manned space flights, it was clear that under the conditions of decrease in mechanical load on the skeleton, bone tis sue can undergo unfavorable changes, in particular, an adaptive decrease in bone mass, to which risk of bone fracture can be related.Analysis of results of multi term study of the effect of microgravity on the bone system of human at Mir orbital station (OS) demonstrated several specific fea tures and patterns of the observed changes [5,7]. The purpose of the present study was to provide data in connection with a new stage of investigations on board International Space Station (ISS) and their analysis that allowed us to establish some new characteristics of changes in the bone system in microgravity, as well as results of osteoporosis correction in clinic. METHODSThirty eight cosmonauts aged 33-53 years (Rus sian and foreign), members of crews of main missions (MMs) and visiting missions (VMs) on board Mir OS, were examined; in addition, 20 cosmonauts after repeated or multiple flights were examined. Duration of flights was five to seven months, but examinations were performed also after flights of smaller (20-30 days) and greater (10-14.5 months) durations. Some cosmonauts participated in several missions; therefore, a practically multiyear monitoring of the state of their bone system was performed. Total of 60 examinations were performed that included several seances of obligatory or widened cyclogram.Abstract-Analysis of the results of long term investigations of bones in cosmonauts on board Mir orbital sta tion(OS) and International Space Station (ISS) (n = 80) was performed. Theoretically predicted (evolution ary predefined) change in mass of different skeleton bones was found to be correlated (r = 0.904) with the position relative to Earth's gravity vector. Vector dependence of bone loss results from local specificity of expression of bone metabolism genes, which reflects mechanic...

show abstract

Analysis of polymorphism of bone metabolism genes and evaluation of the risk of osteopenia in cosmonauts

Cited by 3 publications

References 11 publications

Stem Cells toward the Future: The Space Challenge

Stem Cells toward the Future: The Space Challenge

Impact of g-Load Shift on Temporal Expression Pattern of Apoptosis-linked Proteins in the Rat Mammary Gland

Characteristics of local human skeleton responses to microgravity and drug treatment for osteoporosis in clinic

Contact Info

Product

Resources

About