Analysis of Polarization Images in the Microphysical Blood Parameters Research for the Hematocrit Diagnostics

Abstract

The development of non-invasive optoelectronic technologies for human blood monitoring is one of the important research areas for medicine. A critical analysis of optoelectronic methods of blood research and the micromechanical systems based on them is carried out in this article. A design realization of a polarizing portable system for non-invasive monitoring of hematocrit as one of the basic homeostatic constants of the human body containing information about the microphysical parameters of blood cells has been substantiated. A physical model of polarized radiation conversion in a video information system of laser sensing of a biological research object has been formed. Visual and quantitative differences in the spatial distribution of polarization parameters of the scattered radiation for the states of the body with different hematocrit levels have been revealed. A scheme of a multichannel imaging portable system, based on a smartphone using miniature optical and microelectronic components of information conversion for non-invasive monitoring of microphysical blood parameters, has been created. The system implements the principle of polarimetric blood photometry and a multiparametric analysis of the polarization properties of the laser radiation scattered by blood. The developed portable optoelectronic system, based on a smartphone, can be used for rapid blood diagnostics in disaster medicine and the presence of clinical contraindications to the formation of invasive tests. The proposed polarization-based approach is a promising automated alternative to traditional devices and systems for the research of microphysical blood parameters.

Model-Based Feedback Control for an Automated Micro Liquid Dispensing System Based on Contacting Droplet Generation through Image Sensing

“…Hence the volume of the dispensing liquid should be app priate to cover the whole substrate dot to ensure co-crystallization without redundan Although an integrated robotic sample transfer device that could process fluid samp for mass spectrometry was invented, the system was open-loop controlled, leading droplets not being generated precisely enough [22]. A visual image recognition syst was widely used to control the on-demand movements of motors to reduce position errors [23][24][25][26]. Hence, an automated droplet-on-demand dispensing system with clos loop feedback control is required for the sample preparation of the MALDI-TOFMS [2 In this paper, a home-built, automated micro liquid dispensing system was dev oped and validated for the preparation of samples.…”

“…Although an integrated robotic sample transfer device that could process fluid samples for mass spectrometry was invented, the system was open-loop controlled, leading to droplets not being generated precisely enough [22]. A visual image recognition system was widely used to control the on-demand movements of motors to reduce positioning errors [23][24][25][26]. Hence, an automated droplet-on-demand dispensing system with closed-loop feedback control is required for the sample preparation of the MALDI-TOFMS [27].…”