Analysis of platinum in biological materials by flameless atomic absorption spectrophotometry

Leroy, A; Wehling, M.L.; Sponseller, H.L.; Friauf, Walter S.; Solomon, Robert; Dedrick, Robert L.; Litterst, Charles L.; Gram, T.E.; Guarino, Anita; Becker, D.A.

doi:10.1016/0006-2944(77)90089-8

Cited by 207 publications

(50 citation statements)

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“…Portions of urine collected over 6 h intervals during days 1-3 and over 12 h on days 4-8 were also stored at -20'C. Analysis Pt concentrations in plasma (total Pt), plasma ultrafiltrate (free Pt) and urine were determined by flameless atomic absorption spectrometry (Leroy et al, 1977 0.l0 mg l'. The coefficient of variation is 3.5% (10 tLg ml', n = 6).…”

Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of carboplatin at a dose of 750 mg m-2 divided over three consecutive days

Mulder

Vries²,

Uges³

et al. 1990

Br J Cancer

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Summary Pharmacokinetics of the cisplatin analogue carboplatin were studied in patients with disseminated ovarian and testicular cancer. Carboplatin 750 mg m-2 divided over three consecutive days was given as part of an ablative combination regimen followed by autologous bone marrow transplantation. Platinum (Pt) in plasma, plasma ultrafiltrate and urine was determined up to 96 h after the last drug dose by atomic absorption spectrometry. Carboplatin was measured by high performance liquid chromatography. The curves of ultrafiltrated Pt and carboplatin decayed in a bio-exponential way with t1/2 a of respectively 65 and 70 min and t112 P of repectively 378 and 1014 min. The volumes of distribution (Vd,) were 18 and 25 1 m-2, respectively, and total body clearances (CITB) 79 and 65 ml min-m-2. Both curves overlapped when corrected for the Pt content of carboplatin. A diversion with the three-exponential curve of total Pt occurred between 3 and 6 h.

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Section: Methodsmentioning

confidence: 99%

Pharmacokinetics of carboplatin at a dose of 750 mg m-2 divided over three consecutive days

Mulder

Vries²,

Uges³

et al. 1990

Br J Cancer

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“…Separated plasma was stored at À801C until measurement. Concentrations of t-Pt and f-Pt were determined by flameless atomic absorption spectrophotometry (LeRoy et al, 1977), and those of etoposide were determined by high-performance liquid chromatography (Strife et al, 1981). Pharmacokinetics data were analysed according to the previously reported method (Yamaoka et al, 1978).…”

Section: Pharmacokinetics Studymentioning

confidence: 99%

Feasibility of combination chemotherapy with cisplatin and etoposide for haemodialysis patients with lung cancer

et al. 2003

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Cancer chemotherapy for haemodialysis patients has never been established. To elucidate the feasibility of cisplatin-based combination chemotherapy for haemodialysis patients with lung cancer, a dose escalation study was conducted. Five haemodialysis patients with lung cancer were treated with cisplatin and etoposide. A starting dose of 40 mg m À2 of cisplatin on day 1 and 50 mg m À2 of etoposide on days 1, 3 and 5 were administered as the first course for the first patient. Membrane haemodialysis was regularly performed three times a week and soon after the completion of therapy. By monitoring toxicity and pharmacokinetics data, the dose was escalated course by course and patient by patient. Dose escalation was completed for the first two patients resulting in full-dose chemotherapy consisting of 80 mg m À2 of cisplatin on day 1 and 100 mg m À2 of etoposide on days 1, 3 and 5. Multiple courses of the full-dose chemotherapy were administered to the other three patients. Toxicity was manageable and tolerable for all. Pharmacokinetics data were comparable to those from patients with normal renal function, except for potential long-lasting higher levels of free platinum in the renal insufficiency group. In conclusion, this standard-dose combination chemotherapy was feasible even for haemodialysis patients.

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“…Elemental platinum in cell lysates was determined by flameless atomic absorption spectrometry as previously described, 44 with slight modifications. In brief, an Analyst 600 atomic absorption spectrometer (PerkinElmer Life Science) equipped with a graphite tube atomisator and a platinum hollow cathode lamp was used with the following ther- Common statistical procedures.…”

Section: -34mentioning

confidence: 99%

Vitamin B6 metabolism influences the intracellular accumulation of cisplatin

et al. 2013

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Analysis of platinum in biological materials by flameless atomic absorption spectrophotometry

Cited by 207 publications

References 0 publications

Pharmacokinetics of carboplatin at a dose of 750 mg m-2 divided over three consecutive days

Pharmacokinetics of carboplatin at a dose of 750 mg m-2 divided over three consecutive days

Feasibility of combination chemotherapy with cisplatin and etoposide for haemodialysis patients with lung cancer

Vitamin B6 metabolism influences the intracellular accumulation of cisplatin

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