Analysis of plasma trifluoperazine by gas chromatography and selected ion monitoring

Whelpton, Robin; Curry, Stephen H.; Watkins, G M

doi:10.1016/s0378-4347(00)80448-x

Cited by 13 publications

(1 citation statement)

References 9 publications

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“…Recently reported methods for the quantitation of TFP in plasma include GC-NPD (Gillespie & Sipes, 1981;Roscoe et al, 1982), GC-MS (Midha et al, 1982;Whelpton et al, 1982), and RIA (Midha et al, 1981a). Of these methods, the GC-MS procedure using selected ion monitoring is the most sensitive allowing the determination of TFP plasma concentrations in the 0.078-5.0 ng/ml range.…”

Section: Introduction Resultsmentioning

confidence: 99%

Kinetics of oral trifluoperazine disposition in man.

Midha¹,

Korchinski²,

Verbeeck³

et al. 1983

Brit J Clinical Pharma

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The disposition of trifluoperazine (TFP) was studied in five healthy volunteers following oral administration of a 5 mg tablet. Using a very sensitive GC-MS technique plasma TFP concentrations were measured up until 24 h following drug ingestion. Peak plasma concentrations varied widely (range: 0.53-3.09 ng ml-') and were reached 2.8 ± 0.5 h following ingestion.of the TFP tablet. The apparent terminal elimination half-life of TFP was 12.5 + 1.4 h. The area under the plasma concentration-time curve differed widely between subjects (range: 5.9-17.6 ng ml-' h) suggesting large individual differences in the extent of presystemic TFP elimination.

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Section: Introduction Resultsmentioning

confidence: 99%

Kinetics of oral trifluoperazine disposition in man.

Midha¹,

Korchinski²,

Verbeeck³

et al. 1983

Brit J Clinical Pharma

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A bioequivalency study of two trifluoperazine tablet formulations using ria and GC–MS

Midha

Hawes

Korchinski

et al. 1984

Biopharm & Drug Disp

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Two sensitive analytical procedures, a radioimmunoassay (RIA) and a mass fragmentographic (GC-MS) method, were used to quantitate plasma trifluoperazine concentrations over 24 h in five healthy male volunteers following single 5 mg doses of two trifluoperazine tablet formulations (A and B) in a two-way cross-over design. Bioavailability in terms of area under the plasma concentration versus time curve to 24h or extrapolated to infinity, maximum plasma concentration and time to maximum plasma concentration using either RIA or GC-MS was not statistically significantly different from one formulation to the other. Also, there were no statistically significant differences between GC-MS and RIA values for AUC24(0) and Cmax for each of the two formulations examined. However, the mean AUC24(0) RIA/GC-MS ratios for formulations A and B were 3.1 and 3.4, respectively, while the mean Cmax RIA/GC-MS ratios were 1.7 and 2.1, respectively. These differences in AUC and Cmax are probably mainly due to the relative non-specificity of the RIA antiserum. Thus, where GC-MS is preferred for pharmacokinetic studies, both analytical procedures can be used for comparative single-dose bioequivalence studies of trifluoperazine. However, both the methods should be tested in patients in order to establish the suitability of one procedure over the other for the study of plasma level versus clinical response correlations.

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Measurement of propericiazine in plasma by capillary gas chromatography and selected ion monitoring detection

Leenheer

Jonckheere

Lefevere

et al. 1985

Biol. Mass Spectrom.

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A new method, based upon a selective extraction and gas chromatographic/mass spectrometric analysis, was developed to monitor the effect of combined haemoperfusion-haemodialysis treatment in a case of propericiazine poisoning. The method relies on the selected ion monitoring of the acetate derivatives of propericiazine and its internal standard fluphenazine, after their extraction from 1 ml of alkalinized plasma with n-hexane:isopropanol (8:2, v/v), back-extraction into an acidified water phase, realkalinization and extraction with n-hexane: isopropanol, derivatization with acetic anhydride and gas chromatography on a short (12 m) OV-101 fused silica capillary column. The described procedure is specific and provides between-assay variability of 4.8% CV at 5 micrograms 1(-1) plasma concentration. The method enables quantification down to 1 microgram 1(-1) and hence demonstrates sufficient sensitivity to permit pharmacokinetic or drug monitoring studies.

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Analysis of plasma trifluoperazine by gas chromatography and selected ion monitoring

Cited by 13 publications

References 9 publications

Kinetics of oral trifluoperazine disposition in man.

Kinetics of oral trifluoperazine disposition in man.

A bioequivalency study of two trifluoperazine tablet formulations using ria and GC–MS

Measurement of propericiazine in plasma by capillary gas chromatography and selected ion monitoring detection

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