Analysis of Pharmacologic Adulteration in Dietary Supplements by Capillary Zone Electrophoresis Using Simultaneous Contactless Conductivity and UV Detection

Müller, Larissa; Muratt, Diana Tomazi; Molin, Thaís Ramos Dal; Urquhart, Carolina Gonzalez; Viana, Carine; Carvalho, Leandro Machado de

doi:10.1007/s10337-018-3496-2

Cited by 17 publications

(6 citation statements)

References 30 publications

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“…Müller et al. combined C 4 D with UV‐detection in the CZE analysis of pharmaceuticals. This allowed the detection of compounds which are devoid of chromophores, and, for the compounds accessible by both detectors, the C 4 D gave slightly better LODs.…”

Section: Fundamental Characterization and Instrumental Developmentsmentioning

confidence: 99%

“…Low cost, easy operation, and suitability for many food additives demonstrated usefulness of the instrument for food control in laboratories with tight budget and limited staff expertise. Food supplements available in food shops and internet webshops in Brazil were tested for synthetic pharmaceuticals of four groups (diuretics, antidepressants, laxative and anorexic) with alarming conclusions – the diuretic hydrochlorothiazide was found in more than 12% of the examined samples .…”

Section: Applications Of Ce‐c4dmentioning

confidence: 99%

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Contactless conductivity detection for analytical techniques: Developments from 2016 to 2018

Kubáň

Hauser

2018

Electrophoresis

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The publications concerning capacitively coupled contactless conductivity detection for the 2-year period from mid-2016 to mid-2018 are covered in this update to the earlier reviews of the series. Relatively few reports on fundamental investigations or new designs have appeared in the literature in this time interval, but the development of new applications with the detection method has continued strongly. Most often, contactless conductivity measurements have been employed for the detection of inorganic or small organic ions in conventional capillary electrophoresis, less often in microchip electrophoresis. A number of other uses, such as detection in chromatography or the gauging of bubbles in streams have also been reported.

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Section: Fundamental Characterization and Instrumental Developmentsmentioning

confidence: 99%

Section: Applications Of Ce‐c4dmentioning

confidence: 99%

Contactless conductivity detection for analytical techniques: Developments from 2016 to 2018

Kubáň

Hauser

2018

Electrophoresis

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“…Moreover, according to the World Health Organization, it is recommended to use CE to check the authenticity of herbal raw materials [ 20 ]. The availability of high-performance CE enables its wide application in environmental samples [ 21 ], pharmaceutical analysis [ 22 ], as well as food analysis [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Application of Capillary Electrophoresis to the Analysis of Bioactive Compounds in Herbal Raw Materials

2021

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The article is a summary of scientific reports from the last 16 years (2005–2021) on the use of capillary electrophoresis to analyze polyphenolic compounds, coumarins, amino acids, and alkaloids in teas or different parts of plants used to prepare aqueous infusions, commonly known as “tea” or decoctions. This literature review is based on PRISMA guidelines and articles selected in base of criteria carried out using PICOS (Population, Intervention, Comparison, Outcome, Study type). The analysis showed that over 60% of articles included in this manuscript comes from China. The literature review shows that for the selective electrophoretic separation of polyphenolic and flavonoid compounds, the most frequently used capillary electromigration technique is capillary electrophoresis with ultraviolet detection. Nevertheless, the use of capillary electrophoresis-mass spectrometry allows for the sensitive determination of analytes with a lower limit of detection and gives hope for routine use in the analysis of functional foods. Moreover, using the modifications in electrochemical techniques allows methods sensitivity reduction along with the reduction of analysis time.

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“…At present, various methods for detecting furosemide in slimming products have been reported, including capillary electrophoresis (CE) [9][10][11], ion migration spectrometry (IMS) [12], ion-pair chromatography (IPC) [13,14], liquid chromatography-tandem mass spectrometry (LC-MS/MS) [15], high performance liquid chromatography (HPLC) [16] and ultra-high-pressure liquid chromatography (UHPLC) [17,18]. All these methods rely on expensive equipment, which is difficult to operate and requires trained operators.…”

Section: Introductionmentioning

confidence: 99%

Lateral Flow Immunochromatography Assay for Detection of Furosemide in Slimming Health Foods

Xie

Wang

et al. 2021

Foods

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In recent years, furosemide has been found to be abused in slimming health foods. There is an urgent need for a simpler, faster method for detecting furosemide in slimming health foods. In this study, a rapid, convenient and sensitive lateral flow immunochromatography (LFIA) based on Au nanoparticles (AuNPs) was established for the first time. Under optimal conditions, the qualitative limit of detection (LOD) of the AuNPs-based LFIA was 1.0~1.2 μg/g in slimming health foods with different substrates. AuNPs-LFIA could specifically detect furosemide within 12 min (including sample pretreatment) and be read by the naked eye. The developed AuNPs-LFIA showed high consistency with liquid chromatography with tandem mass spectrometry (LC-MS/MS), and no false positive or false negative results were found in spiked slimming health foods, proving that the AuNPs-LFIA should be accurate and reliable. The AuNPs-LFIA reported here provides a serviceable analytical tool for the on-site detection and rapid initial screening of furosemide for the first time.

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Analysis of Pharmacologic Adulteration in Dietary Supplements by Capillary Zone Electrophoresis Using Simultaneous Contactless Conductivity and UV Detection

Cited by 17 publications

References 30 publications

Contactless conductivity detection for analytical techniques: Developments from 2016 to 2018

Contactless conductivity detection for analytical techniques: Developments from 2016 to 2018

Application of Capillary Electrophoresis to the Analysis of Bioactive Compounds in Herbal Raw Materials

Lateral Flow Immunochromatography Assay for Detection of Furosemide in Slimming Health Foods

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