Analysis of pesticide residues in commercially available chenpi using a modified QuEChERS method and GC-MS/MS determination

Li, Shuang; Yu, Peipei; Zhou, Ceng; Tong, Ling; Li, Dongxiang; Yu, Zhiguo

doi:10.1016/j.jpha.2019.01.005

Cited by 49 publications

(29 citation statements)

References 26 publications

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“…Potential adverse effects of the combination of HMs with chemotherapy may appear due to direct toxic effects of HMs, herb-herb, or herb-drug interactions, which are considered major concerns among patients with CRC, especially for those undergoing active chemotherapy (56). However, commonly used HMs such as C. reticulata, A. membranaceus and SJZD are generally perceived as relatively safe treatments with rarely reported adverse effects (57)(58)(59)(60). Studies on animal and clinical trials have shown the safety of these HMs.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity — a Systematic Review and Meta-Analysis

et al. 2021

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Purpose: Chemotherapy-induced gastrointestinal (CIGI) toxicity affects the quality of life of patients with colorectal cancer (CRC) and the clinical application of treatment drugs. This review aims to evaluate the efficacy of traditional herbal medicines (HMs) in alleviating symptoms of CIGI toxicity (including nausea and vomiting, anorexia, diarrhea, constipation, oral mucositis, abdominal pain, and abdominal distension), and to explore further individual herb or herbal combinations in alleviating the CIGI toxicity.Methods: Nine electronic databases were screened from 2010 to 2020. Twenty-two randomized controlled trials with a total of 1,995 patients evaluating the complementary efficacy of HMs with chemotherapy compared with chemotherapy-alone were included. Further, sensitivity analyses of orally administered multi-ingredient HM interventions were explored based on the composition of HM interventions.Results: The meta-analysis showed that HM treatment combined with chemotherapy significantly alleviated the overall CIGI toxicity (RR = 0.78 [0.72, 0.84], p < 0.001, I2 = 44%), nausea and vomiting (RR = 0.74 [0.66, 0.82], p < 0.001, I2 = 35%), diarrhea (P = 0.02, RR = 0.64, 95% CI = 0.44–0.93, I2 = 50%), oral mucositis (RR = 0.65 [0.48, 0.88], P = 0.005, I2 = 24%), and abdominal distension (RR = 0.36 [0.18, 0.73], P = 0.004, I2 = 0%). However, no statistically significant effects of HMs were shown in studies with a double-blind design for CIGI toxicity. Based on the ingredients of the HMs, further sensitivity analyses identified five herbs [Glycyrrhiza uralensis Fisch., Atractylodes macrocephala Koidz., Astragalus membranaceus (Fisch.) Bge., Codonopsis pilosula (Franch.) Nannf., and the pericarp of Citrus reticulata Blanco.] that were associated with significant reductions in CIGI toxicity.Conclusion: A statistically significant effect of HMs combined with chemotherapy on alleviating the overall CIGI toxicity, nausea and vomiting, diarrhea, oral mucositis, or abdominal distension is only shown in studies without a double-blind design. Further well-designed, double-blinded, large-scaled randomized controlled trials (RCTs) are warranted to comprehensively evaluate the treatment efficacy. Further clinical research that includes the five herbs with chemotherapy for patients, the safety of the combinations of these herbs, and the potential synergistic effects of these combinations of herbs should be conducted.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity — a Systematic Review and Meta-Analysis

et al. 2021

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“…Excellent recoveries and repeatability (RSD) of the pesticides analyzed by LC-MS-MS were obtained at two different spiked concentrations levels (Table 1) except for thiabendazole, which displayed low recoveries. This is most likely because, thiabendazole is a planar molecule and may have been absorbed by the GCB in the dSPE procedure [17]. GC-MS analysis was performed using a 30 m x 0.25 mm x 0.25 µm GC column (Zebron ZB-5MSi Guardian, Phenomenex) on a gas chromatograph (Agilent 6890N) with a network mass spectrometer (Agilent 5973, Agilent Technologies, Palo Alto, California, USA) [16].…”

Section: Isolation Of Pesticides From Samples [4]mentioning

confidence: 99%

“…It was able to remove interferences such as organic acids and pigments. Downstream analysis of pesticides by both LC-MS-MS and GC-MS proved to be vital because some pesticides in our screen were best analyzed by LC-MS-MS while others were more easily analyzed by GC-MS [17,18] CONCLUSION Chemicals hazards due to pesticides in fruits and vegetables can be detected using various techniques. This review highlights various techniques of extracting pesticides; further detecting these using sophisticated instruments like GC-MS, LC-MS.…”

Section: Isolation Of Pesticides From Samples [4]mentioning

confidence: 99%

Investigating the presence of pesticides in fruits and vegetables by the chromatographic techniques: A review

Borkar

Gonsalves

2020

JAPR

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“…One such report was on "Ginseng" where 62 out of the 107 compounds were eluted by a mixed solution of acetone and toluene in a PSA column [10]. The other is a report on "Chenpi" where 67 out of the 107 compounds were purified by a dispersed solid phase [11]. In these reports, since only a few compounds could be analyzed, it became a challenge to expand the number of pesticides that could be analyzed by GC-MS/MS.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of an analysis method for pesticide residues by gas chromatography–tandem mass spectrometry in Daikenchuto

et al. 2021

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Daikenchuto (DKT) is one of the most widely used “Kampo” in Japan as a representative of herbal medicine. Because DKT is made from a natural product like food, it requires the management of pesticides; therefore, an analysis of residual pesticides in Kampo is required. The World Health Organization (WHO) indicates that pesticide residue analysis by the U.S. Pharmacopeia (USP) is required. USP defines 107 compounds containing organochlorine pesticides and organophosphorus pesticides and their metabolites, which have a high residual risk. Accordingly, to guarantee the safety of herbal medicines according to global standards is a very important issue. In this study, we developed an analytical method for 91 compounds, which are listed in USP, using DKT as the subject. The method could extract pesticides from DKT with acetone, elute pesticides with acetonitrile using a SepPak C18 column (5 g) and with ethyl acetate using a DSC-NH2 column (2 g), and perform simultaneous analyses by gas chromatography–tandem mass spectrometry (GC–MS/MS). This method, which could quantify 88 compounds, was validated according to USP. A pesticide residue analysis method that meets USP requirements enables the analysis of pesticide residues with a high residue risk and contributes to improving the safety of “Kampo” and other herbal medicines.

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Analysis of pesticide residues in commercially available chenpi using a modified QuEChERS method and GC-MS/MS determination

Cited by 49 publications

References 26 publications

Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity — a Systematic Review and Meta-Analysis

Efficacy of Herbal Medicines Intervention for Colorectal Cancer Patients With Chemotherapy-Induced Gastrointestinal Toxicity — a Systematic Review and Meta-Analysis

Investigating the presence of pesticides in fruits and vegetables by the chromatographic techniques: A review

Development and validation of an analysis method for pesticide residues by gas chromatography–tandem mass spectrometry in Daikenchuto

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