Analysis of permeability and biological properties of dentin treated with experimental bioactive glasses

Safe and Durable Treatment of Dentin Hypersensitivity via Nourishing and Remineralizing Dentin Based on β‐Chitooligosaccharide Graft Derivative

“…However, this part of the in vitro experimental study can only simulate the real oral environment, and some aspects may be considered as limiting factors, such as wear resistance, the clinical buffering capacity of dentin and saliva, pressure and gap of the dental pulp, etc. [ 38,41 ] Therefore, further studies require to determine the degree of clinical success of biomaterial CAD.…”

“…Those with high discrepancies in permeability values were eliminated from the experiment, and those with permeability similar to the average were retained. [ 38 ] After two weeks of desensitization, a total of 30 dentin tablets were randomly assigned to five experimental groups ( n = 6), and the DFF reduction rate (∆DFF) was measured using a DFF measurement device (Auto Science, China). The deionized water in the peristaltic pump tube passed through a measuring holder composed of a syringe, a hollow sponge pad, and the dentin disks (the treatment surface was facing the water flow direction) at a constant flow rate of 6.0 mL min −1 .…”

Effectiveness and cytotoxicity of two desensitizing agents: a dentin permeability measurement and dentin barrier testing in vitro study

“…This type of desensitizer usually exhibits strong cytotoxicity in conventional in vitro tests, such as the filter diffusion and extract tests, where the contact mode between the materials and cells, cell types, and cell growth state vary from those observed in vivo. A recent study showed that desensitizers containing sodium fluoride were highly cytotoxic to monolayer gingival fibroblast cells; however, as the authors noted,the results of direct contact between materials and cells can be obviously inconsistent with clinical findings [ 9 ]. The SV40 large T-antigen-transfected rat odontoblast-like cells used in this study were obtained from rat dental papilla.…”

“…Therefore, treatment strategies include sealing of the dentinal tubules to reduce dentin permeability and the activity of pulp nerves [ 6 ]. Dental materials for the occlusion of open dentinal tubules include inorganic fillers, polymers, protein denaturing materials, and tooth remineralization materials [ 7 – 9 ], which are marketed as in-office or at-home use products. With the continuous introduction of novel desensitizing agents, it is particularly important to evaluate their effectiveness and biocompatibility using appropriate in vitro models.…”

Avaliação de um biovidro experimental na perda de superfície e oclusão tubular da dentina, e da sua associação à terapia de fotobiomodulação na diferenciação de células da polpa dentária humana

“…Quando em contato com fluido corporal, o biovidro é rapidamente degradado, liberando íons como Si 4+ , Ca 2+ , PO4 3e Na + e formando uma camada de hidroxiapatita carbonatada na superfície dentinária e no interior dos túbulos (24). Como essa camada de hidroxiapatita é semelhante ao mineral hidroxiapatita encontrado na dentina, ambos se ligam quimicamente, promovendo uma adesão mais forte entre as partículas do biovidro e a superfície dentinária (63). Além disso, esses depósitos parecem ser resistentes à água e ácidos, além de apresentarem resistência mecânica (4).…”