Analysis of pepper and capsicum oleoresins by high-performance liquid chromatography—mass spectrometry and field desorption mass spectrometry

Past, Present and Future of Metabolomic Studies

“…tarafından 1984 yılında gerçekleştirilen ve karabiber bileşenlerini inceleyen araştırma "sıvı kromatografisi-kütle spektrometresi (LC-MS)" cihazıyla yapılan ilk metabolomik çalışmalardandır. 21 1989 yılında ise Bell ve ark., vücut sıvılarından metabolit profilleme deneyleri yaparak, "nükleer manyetik rezonans (NMR)" cihazını metabolomik çalışmalara katan ilk grup olmuşlardır. 22 LC-MS ve NMR yöntemlerinin de katılımıyla beraber 1990'lı yıllar her gelişen analitik ve biyoinformatik teknolojinin metabolomik çalışmalara da entegre edilmeye başlandığı yıllar olmuştur.…”

Pharmacometabolomics in Early‐Phase Clinical Development

“…Examples include references in ancient Chinese and Ayurvedic medical literature to insects attracted to patients with sweet‐tasting urine as markers of diabetes, and the use, albeit erroneous, of “black bile” and “phlegm” as markers of mood and alertness, respectively . However, because of the complexity of interactions between the multitude of metabolites and respective physiological and pathological states, and consequent dependence on sophisticated bioinformatics and powerful analytical and computational tools, the field has made significant progress only in last few decades ( Table ) …”

“…5 However, because of the complexity of interactions between the multitude of metabolites and respective physiological and pathological states, and consequent dependence on sophisticated bioinformatics and powerful analytical and computational tools, the field has made significant progress only in last few decades ( Table 1). 1,4,5,8,10,[14][15][16][17][18][19][20][21][22][23][24][25][26][27][28] The term "metabonomics" (later converging with the parallel coined "metabolomics") was coined in 1999 as "the quantitative measurement of the dynamic multiparametric metabolic response of living systems to pathophysiological stimuli or genetic modification." 8 It captures a dynamic process of metabolic changes over time in response to internal and external influences.…”

Homocapsaicin: nomenclature, indexing and identification

“…Seven patents 4,6,10,19,22,41,52 mention homocapsaicin as a component of an invention and attach the 7-ene-9-methyl structure to it by name or by drawing. Another 17 sets of authors, 3,14,[27][28][29]36,40,49,[53][54][55][56]59,62,67,71,73 who explore the composition of chilli peppers or related products, just assume that the most common, naturally occurring isomer of homocapsaicin is (E)-7,9-HC and offer no evidence for the structural assignment.…”