Analysis of Patterns of Gene Expression Variation within and between Ethnic Populations in Pediatric B-ALL

Hicks, Chindo; Miele, Lucio; Koganti, Tejaswi; Young-Gaylor, LaFarra; Rogers, Deidre; Vijayakumar, Vani; Megason, Gail

doi:10.4137/cin.s11831

Cited by 14 publications

(15 citation statements)

References 62 publications

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“…Similar results were found for omalizumab PK in Japanese and Caucasian populations [328,329]. Differences in gene/target expression [330], tumor burden [331], disease progression, FcγR polymorphism have been noted between different ethnic groups, but a clinically significant effect on mAb PK has not been recorded in the clinic. Nonetheless, the effects of race may be understudied, and long-term studies in diverse populations may be needed to evaluate appropriately the role of race on mAb PK [332].…”

Section: Racesupporting

confidence: 75%

Understanding Inter-Individual Variability in Monoclonal Antibody Disposition

Thomas

Balthasar

2019

Antibodies

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Monoclonal antibodies (mAbs) are currently the largest and most dominant class of therapeutic proteins. Inter-individual variability has been observed for several mAbs; however, an understanding of the underlying mechanisms and factors contributing to inter-subject differences in mAb disposition is still lacking. In this review, we analyze the mechanisms of antibody disposition and the putative mechanistic determinants of inter-individual variability. Results from in vitro, preclinical, and clinical studies were reviewed evaluate the role of the neonatal Fc receptor and Fc gamma receptors (expression and polymorphism), target properties (expression, shedding, turnover, internalization, heterogeneity, polymorphism), and the influence of anti-drug antibodies. Particular attention is given to the influence of co-administered drugs and disease, and to the physiological relevance of covariates identified by population pharmacokinetic modeling, as determinants of variability in mAb pharmacokinetics.

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Section: Racesupporting

confidence: 75%

Understanding Inter-Individual Variability in Monoclonal Antibody Disposition

Thomas

Balthasar

2019

Antibodies

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“…Their results suggested that the mutation frequencies of some genes vary according to race, which could benefit cancer diagnosis and treatment. Except cancer genomes, racial specificity was also observed in other molecular features, such as gene expression in pediatric B-Precursor acute lymphoblastic leukemia [12] and methylation in prostate cancer [13]. However, these studies are still limited to assess the full impact of race in human carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Racial Differences in Esophageal Squamous Cell Carcinoma: Incidence and Molecular Features

Chen

Zhou

Yang

et al. 2017

BioMed Research International

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The incidence and histological type of esophageal cancer are highly variable depending on geographic location and race/ethnicity. Here we want to determine if racial difference exists in the molecular features of esophageal cancer. We firstly confirmed that the incidence rate of esophagus adenocarcinoma (EA) was higher in Whites than in Asians and Blacks, while the incidence of esophageal squamous cell carcinoma (ESCC) was highest in Asians. Then we compared the genome-wide somatic mutations, methylation, and gene expression to identify differential genes by race. The mutation frequencies of some genes in the same pathway showed opposite difference between Asian and White patients, but their functional effects to the pathway may be consistent. The global patterns of methylation and expression were similar, which reflected the common characteristics of ESCC tumors from different populations. A small number of genes had significant differences between Asians and Whites. More interesting, the racial differences of COL11A1 were consistent across multiple molecular levels, with higher mutation frequency, higher methylation, and lower expression in White patients. This indicated that COL11A1 might play important roles in ESCC, especially in White population. Additional studies are needed to further explore their functions in esophageal cancer.

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“…Several of the hallmarks of BCR-ABL1-like ALL identified in the COG high-risk cohorts, including increased frequencies of CRLF2 aberration and JAK2 mutation, have been associated with Hispanic/Latino ethnicity. 7,10 The lack of Hispanic/Latino patients in the DCOG/COALL cohort may have contributed to the lower frequency of CRLF2 and JAK2 abnormalities in this cohort, and the lower number of BCR-ABL1-like cases identified by the PAM signature. Likely due to these cohort differences, the prognostic value of the HC and PAM signatures is most discriminative in the cohort of patients in whom these signatures were identified, DCOG/COALL and COG P9906, respectively.…”

confidence: 99%