Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species

Hoyle, Charles H.V.; Hill, J; Sanger, Gareth J.; Andrews, Paul

doi:10.1016/s0167-0115(03)00113-7

Cited by 13 publications

(11 citation statements)

References 51 publications

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“…The percentage sequence similarity was highest between the shrew and human in all the three sequences, further confirmed by the mtDNA analysis showing that the insectivore may have more in common with the human than rodents or lagomorphs [5]. This result also agrees well with two works on pancreatic polypeptides [6] and the immunoglobulin µ gene [7] in the house musk shrew. Increasing the data set based on nuclear genes for insectivore species will further clarify the position of the house musk shrew in relation to the other shrew species, and will also complement available data based on mtDNA.…”

Section: Discussionsupporting

confidence: 84%

Development and Characterization of CATS Markers for Genetic Linkage Mapping in the House Musk Shrew, Suncus murinus

et al. 2005

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Section: Discussionsupporting

confidence: 84%

Development and Characterization of CATS Markers for Genetic Linkage Mapping in the House Musk Shrew, Suncus murinus

et al. 2005

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“…The Asian house musk shrew Suncus murinus (laboratory name; suncus) of the order Eulipotyphla (formerly Insectivora) is thought to resemble specialized placental mammals (eutherians) [33]. Genetic evidence also indicates that the suncus is more closely related to primates than to rodents [7], and so it may provide a phylogenic bridge between rodent and primate studies . A relatively well developed trigeminal sensory system is observed in suncus [9], possibly to compensate for the relatively degenerate vision system.…”

Section: Introductionmentioning

confidence: 99%

Comparative Anatomy of Gastrin-releasing Peptide Pathways in the Trigeminal Sensory System of Mouse and the Asian House Musk Shrew <i>Suncus murinus</i>

Takanami

Inoue

Mukai

et al. 2016

Acta Histochemica et Cytochemica

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Gastrin-releasing peptide (GRP) has recently been identified as an itch-signaling molecule in the primary afferents and spinal cord of rodents. However, little information exists on the expression and localization of GRP in the trigeminal somatosensory system other than in rats. We examined the generality of the trigeminal GRP system in mammals using two distinct species, suncus as a model of specialized placental mammals known to have a well-developed trigeminal sensory system and mice as a representative small laboratory animal. We first analyzed the gross morphology of the trigeminal somatosensory system in suncus to provide a brainstem atlas on which to map GRP distribution. Immunohistochemical analyses showed that 8% of trigeminal ganglion neurons in suncus and 6% in mice expressed GRP. Expression was restricted to cells with smaller somata. The GRP-containing fibers were densely distributed in the superficial layers of the caudal part of the trigeminal spinal nucleus (Vc) but rare in the rostral parts, both in suncus and mice. Expression of GRP receptor mRNA and protein was also detected in the Vc of suncus. Taken together, these results suggest that the trigeminal GRP system mediating itch sensation is conserved in mammals.

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“…The actions of CBDA on the GI tract have never been studied, and as such the present study aimed to further investigate the actions of CBD in the intestine, and to determine whether or not CBDA has pharmacologic actions in the GI tract using Suncus murinus (House musk shrew). S. murinus is a small insectivore (weighing < 100 g), which is both phylogenetically (Colbert, 1969) and physiologically (Hoyle et al, 1998(Hoyle et al, , 2003 closer to primates than rodents, and has been shown to be a robust model to study the contractility of the gastrointestinal tract Naylor, 1999a, 1999b).…”

Section: Introductionmentioning

confidence: 99%

The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus

et al. 2011

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Cannabidiol (CBD) has been shown to inhibit gastrointestinal (GI) transit in pathophysiologic in vivo models, while having no effect in physiologic controls. The actions of the precursor of CBD, cannabidiolic acid (CBDA), have not been investigated in the GI tract. The actions of these phytocannabinoids on the contractility of the GI tract of Suncus murinus were investigated in the current study. The effects of CBDA and CBD in resting state and pre-contracted isolated intestinal segments, and on the contractile effects of carbachol and electrical field stimulation (EFS) on the intestines of S. murinus were examined. CBDA and CBD induced a reduction in resting tissue tension of isolated intestinal segments which was not blocked by the cannabinoid CB1 receptor antagonist, AM251, the CB(2) receptor antagonist AM630, or tetrodotoxin. CBDA and CBD reduced the magnitude of contractions induced by carbachol and the tension of intestinal segments that were pre-contracted with potassium chloride. In tissues stimulated by EFS, CBDA inhibited contractions induced by lower frequencies (0.1-4.0 Hz) of EFS, while CBD inhibited contractions induced by higher frequencies (4.0-20.0 Hz) of EFS. The data suggest that CBDA and CBD have inhibitory actions on the intestines of S. murinus that are not neuronallymediated or mediated via CB(1) or CB(2) receptors.

show abstract

Analysis of pancreatic polypeptide cDNA from the house musk shrew, Suncus murinus, suggests a phylogenetically closer relationship with humans than for other small laboratory animal species

Cited by 13 publications

References 51 publications

Development and Characterization of CATS Markers for Genetic Linkage Mapping in the House Musk Shrew, Suncus murinus

Development and Characterization of CATS Markers for Genetic Linkage Mapping in the House Musk Shrew, Suncus murinus

Comparative Anatomy of Gastrin-releasing Peptide Pathways in the Trigeminal Sensory System of Mouse and the Asian House Musk Shrew <i>Suncus murinus</i>

The effects of cannabidiolic acid and cannabidiol on contractility of the gastrointestinal tract of Suncus murinus

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