2011
DOI: 10.1001/archinternmed.2010.482
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Analysis of Overall Level of Evidence Behind Infectious Diseases Society of America Practice Guidelines

Abstract: More than half of the current recommendations of the IDSA are based on level III evidence only. Until more data from well-designed controlled clinical trials become available, physicians should remain cautious when using current guidelines as the sole source guiding patient care decisions.

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Cited by 147 publications
(116 citation statements)
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“…5 That is, the most skeptical decision makers may be the best informed about the limitations of available evidence. A growing body of work suggests that even widely used standards, such as ambulatory care metrics that are endorsed by key quality measurement organizations 6 and infectious disease treatment guidelines promulgated by the Infectious Diseases Society of America, 7 are commonly supported primarily by expert opinion or a methodologically suboptimal evidence base. Moreover, guidelines supported solely by observational evidence and/or expert opinion are commonly refuted and replaced when subjected to the more rigorous test of a randomized controlled trial.…”
mentioning
confidence: 99%
“…5 That is, the most skeptical decision makers may be the best informed about the limitations of available evidence. A growing body of work suggests that even widely used standards, such as ambulatory care metrics that are endorsed by key quality measurement organizations 6 and infectious disease treatment guidelines promulgated by the Infectious Diseases Society of America, 7 are commonly supported primarily by expert opinion or a methodologically suboptimal evidence base. Moreover, guidelines supported solely by observational evidence and/or expert opinion are commonly refuted and replaced when subjected to the more rigorous test of a randomized controlled trial.…”
mentioning
confidence: 99%
“…In neurosurgery, 24.4% of the guidelines are based mainly on Level I recommendations; with neurosurgical vascular guidelines, this percentage is significantly higher: 51.9%. Some other specialties have Level I recommendations similar to neurosurgery, including endocrinology [20], infectious diseases [21] and hepatology [22]. Vascular neurosurgery is also the subspecialty with the highest publication rate in neurosurgery [5] and is the third most used in clinical practice (according to Table 3).…”
Section: Discussionmentioning
confidence: 99%
“…However, several evaluations of guidelines for long-term conditions have shown that only 6-16% of guidelines are based on level a evidence. [8][9][10] Guidelines do not address patient beliefs and values.…”
Section: Disorder Zonementioning
confidence: 99%