Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study

Ding, Ting; Tian, Weijun; Zhang, Jinjin; Cui, Pengfei; Chen, Zhe; Zhou, Shanshan; Yuan, Shengjie; Ma, Wenqing; Zhang, Minli; Rong, Yueguang; Chang, Jiang; Miao, Xiaoping; Ma, Xiangyi; Wang, Shixuan

doi:10.3389/fmed.2021.635255

Cited by 95 publications

(83 citation statements)

References 29 publications

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“…In this paper, we aimed to identify and evaluate the existing scientific literature and provide suggestions for future research. Using a pre-specified search protocol (available at: https://osf.io/xg3mw/), we identified seven small studies reporting on menstrual cycle features during the pandemic, either in relation to the COVID-19 pandemic period (Table 1; (8)(9)(10)(11)) or COVID-19 infection/illness specifically (Table 2; (12)(13)(14)). Articles were included if they described features of the menstrual cycle (e.g., cycle length, regularity, heaviness, pain, PMS symptoms) before and during, or over the course of, the COVID-19 pandemic.…”

mentioning

confidence: 99%

The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities

Sharp¹,

Fraser²,

Sawyer³

et al. 2021

Preprint

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Since the beginning of the COVID-19 pandemic, discussions on social media and blogs have indicated that women have experienced menstrual changes, including altered menstrual duration, frequency, regularity, and volume (heavier bleeding and clotting), increased dysmenorrhea, and worsened premenstrual syndrome. There have been a small number of scientific studies of variable quality reporting on menstrual cycle features during the pandemic, but it is still unclear whether apparent changes are due to COVID-19 infection/illness itself, or other pandemic-related factors like increased psychological stress and changes in health behaviours. It is also unclear to what degree current findings are explained by reporting bias, recall bias, selection bias and confounding factors. Further research is urgently needed. We provide a list of outstanding research questions and potential approaches to address them. Findings can inform policies to mitigate against gender inequalities in health and society, allowing us to build back better post-COVID.

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mentioning

confidence: 99%

The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities

Sharp¹,

Fraser²,

Sawyer³

et al. 2021

Preprint

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show abstract

“…Ding et al’s recent study from Wuhan, China to investigate the relationship between COVID-19 disease and ovarian function in reproductive-aged women changes our treatment perspective [ 20 ]. Female COVID-19 patients of reproductive age were recruited between January 28 and March 8, 2020 from Tongji Hospital in Wuhan.…”

Section: Discussionmentioning

confidence: 99%

“…Female COVID-19 patients of reproductive age were recruited between January 28 and March 8, 2020 from Tongji Hospital in Wuhan. Ovarian injury, including declined ovarian reserve and reproductive endocrine disorder, was observed in women with COVID-19 [ 20 ]. Ding et al strongly suggest that more attention should be paid to ovarian function under this pandemic, especially regarding reproductive-aged women [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Will Procreation Ever Be The Same After COVID-19?

Allahbadia

2021

J Obstet Gynecol India

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Medically assisted procreation will never be the same again after this China Virus epidemic. With billions of lives being affected by this damaging global pandemic, medically assisted procreation services were not left unharmed with far-reaching consequences. New challenges are now emerging concerning COVID-19, such as associated reproductive implications and the consequences of assisted and natural procreation in the presence of acute SARS-CoV-2 infection and delayed consequences after patient recovery. There is a hypothesis that testicular damage and subsequent infertility may result following COVID-19 infection and the possibility of sexual transmission, as SARS-CoV-2 has been identified in the semen of infected patients. Vaccine hesitancy in young women planning pregnancies has been heightened because of the spread of misinformation on social media stating that COVID-19 vaccines will cause sterility in women. Reassuring data from accidental pregnancies that have occurred in the clinical trials of approved COVID-19 vaccines indicate that vaccination does not harm fertility or increase the rate of miscarriage. Scientists have quickly related to good tissue practices in vitro fertilization and a rethink is on about encouraging biopsies and focusing on safe vitrification protocols keeping in mind that ova, sperm, and embryos could be possible vectors for disease transmission with the limited research on the SARS-CoV-2 virus. Going ahead with segmented IVF without delay, freezing the generated embryos and pushing back the embryo transfer after the pandemic appears to be the best strategy at present. An international group of researchers have proposed a prognostic stratification of more vulnerable infertility cases in order to plan a progressive restart of worldwide fertility treatments.

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Section: Covid-19 and Female Fertilitymentioning

confidence: 99%

“…A study by Ding et al [ 14 ] showed the effect of COVID-19 on the ovarian function in women whereby higher levels of testosterone and prolactin, and lower levels of AMH (Anti-Müllerian hormone) were observed in infected patients as opposed to their healthy counterparts. Therefore, ovarian reserve can be significantly reduced in such patients [ 14 ]. On the contrary, Li et al’s study did not show any alteration in sex hormones and AMH levels; but did notice delayed menstrual cycle and changes in menstrual volume in some patients [ 15 ].…”

Section: Covid-19 and Female Fertilitymentioning

confidence: 99%

COVID-19 and fertility—at the crossroads of autoimmunity and thrombosis

et al. 2021

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The SARS-CoV-2 virus is known to mediate attack via ACE-2 Receptor, thus having adverse effects on cardiovascular, respiratory, digestive and reproductive systems, the latter being an area of emerging concern, due to the associated impact on fertility, with potential for an outsized effect on population distribution and socioeconomic road map in subsequent years. This narrative review aims to put forth the current evidence of effect of SARS-CoV-2 on human fertility from a multipronged immunologic, haematologic, and gynaecologic perspective; highlighting the areas of contradiction and potential future measures. A literature search was conducted through the MEDLINE and SCOPUS databases to identify articles on the subject in English. Relevant information was extracted from around 300 articles for this review. The existing data give non-conclusive evidence about the impact of SARS-CoV-2 infection on fertility; however, a greater impact on male fertility as compared to females merits further exploration. However, reproduction and fertility is a key concern and considering the pandemic is prolonged, natural conception or ART require extra precautions. Supplementary Information The online version contains supplementary material available at 10.1007/s00296-021-04977-2.

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Analysis of Ovarian Injury Associated With COVID-19 Disease in Reproductive-Aged Women in Wuhan, China: An Observational Study

Cited by 95 publications

References 29 publications

The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities

The COVID-19 pandemic and the menstrual cycle: research gaps and opportunities

Will Procreation Ever Be The Same After COVID-19?

COVID-19 and fertility—at the crossroads of autoimmunity and thrombosis

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