Analysis of outcomes following surgical treatment of thymolipomatous myasthenia gravis: comparison with thymomatous and non-thymomatous myasthenia gravis

Huang, Chien Sheng; Li, Wing Yin; Lee, Pei Chen; Kao, Ko-Pei; Chou, Teh Ying; Wu, Mei-Han; Hsu, Han Shui; Wu, Yu Chung; Hsu, Wen Hu; Huang, Bin

doi:10.1093/icvts/ivt531

Cited by 13 publications

(19 citation statements)

References 20 publications

(40 reference statements)

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“…According to our review of the literature, the largest size of thymolipomas that have been reported in the literature is 36 cm and their weight ranges from 31 g to 16 kg (5,8,14). These tumors are sometimes associated with parathymic disorders such as myasthenia gravis, Graves' disease, hypogammaglobulinemia, aplastic anemia, red cell aplasia, and Hodgkin's disease (1,(3)(4)(5)(6). The incidence of myasthenia gravis associated with thymolipoma is between 2.8 % and 50 % (5).…”

Section: Resultsmentioning

confidence: 99%

“…Patients were asked about their symptoms and chest-x ray were performed, and if necessary CT of the thorax. The modified Osserman's classification was used to assess the severity of myasthenia gravis throughout the patients' preoperative care and postoperative follow-up (4).…”

Section: This Retrospective Study Was Conducted At Sureyyapasa Chest mentioning

confidence: 99%

“…Up to 2008, less than 200 cases of thymolipoma had been reported in the world literature (3). This tumor occurs more frequently in young adults (4). Many patients are asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

“…Others may present with nonspecific symptoms such as chest pain and dyspnea. The tumor is sometimes associated with parathymic disorders such as myasthenia gravis, Graves' disease, hypogammaglobulinemia, aplastic anemia, red cell aplasia, and Hodgkin's disease (1,(3)(4)(5)(6). Chest X-ray may be normal or it may show an abnormal radiological appearance such as cardiomegaly, a mediastinal mass or mediastinal widening (3,6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Surgical resection is the treatment of choice in the patients with thymolipoma (5). Few studies have analyzed the clinical and radiological features and the surgical outcomes of this tumor (4,5,7,8). We present an evaluation of the clinical and radiological features and the surgical outcomes in 11 cases of thymolipoma.…”

Section: Introductionmentioning

confidence: 99%

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Mediastinal Thymolipoma: An Evaluation of the Clinical and Radiological Features and the Surgical Outcomes in 11 Cases

Oruç¹,

Ekinci²,

Yilmaz³

et al. 2016

West Indian Med J

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Background: Thymolipoma is a rare benign tumor of the mediastinum, accounting for 2-9 % of all thymic tumors. Although many case reports have been published in the literature, few studies have analyzed the clinical and radiological features and the surgical outcomes of this tumor. Aim: To evaluate the clinical and radiological features and the surgical outcomes of the patients with thymolipoma. Methods: We reviewed the records of pathology department from the beginning of 2005 to the end of 2013. Results: We identified 11 patients with thymolipoma. There were eight male and three female patients. Their ages ranged from 27 to 72 years, with mean age of 40 years. All patients described pulmonary or extrapulmonary symptoms. Two patients (18.2 %) had myasthenia gravis. Chest X-ray was normal in four patients. Computed tomography of the thorax revealed a mass located in the anterior mediastinum in all patients. It showed fat attenuation in four of 11 patients (36.4 %). Thymectomy was performed in all patients. The surgical approach was thoracotomy in five, sternotomy in four, and video-assisted thoracic surgery in two. Thymolipomas ranged in size from 4 to 33 cm. One patient died two years after surgery. None of remaining patients had evidence of recurrence on follow-up. Conclusions: Thymolipoma is a rare tumor of the thymus. It may be associated with myasthenia gravis. Surgical resection is the treatment of choice in the patients with thymolipoma. Complete surgical resection is the cure in most patients.

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Section: Resultsmentioning

confidence: 99%

Section: This Retrospective Study Was Conducted At Sureyyapasa Chest mentioning

confidence: 99%

“…Up to 2008, less than 200 cases of thymolipoma had been reported in the world literature (3). This tumor occurs more frequently in young adults (4). Many patients are asymptomatic.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mediastinal Thymolipoma: An Evaluation of the Clinical and Radiological Features and the Surgical Outcomes in 11 Cases

Oruç¹,

Ekinci²,

Yilmaz³

et al. 2016

West Indian Med J

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Fatty Tumor Compressing the Heart

2016

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A man in his 40s training for weight-lifting presented with newonset progressive dizziness, lightheadedness, and shortness of breath. His medical and family history as well as review of other systems were unremarkable. Physical examination revealed a positive Kussmaul sign and pulsus paradoxus but no cardiac murmurs. There was no pedal edema, clubbing, or cyanosis. An electrocardiogram demonstrated sinus tachycardia. Results of a complete blood cell count and biochemical panel were within reference ranges. A chest radiograph revealed convexity on the right heart border suggestive of cardiomegaly (Figure 1A). Echocardiography demonstrated normal cardiac chambers and valves. However, an echogenicity was noted compressing the superior vena cava and right ventricle. The patient subsequently underwent computed tomographic imaging of the chest that revealed a large, 16.2 × 6.8 × 5.6-cm anterior mediastinal mass compressing the right cardiac structures, particularly the superior vena cava. The mass consisted mostly of fat attenuation, but was interspersed with nodular densities (Figure 1B). Tumor marker levels, including α-fetoprotein, lactate dehydrogenase, and β-human chorionic gonadotropin, were within reference ranges. Chest radiography A Chest tomography B 1. Chest imaging. A, Radiograph showed a convexity on the right heart border and cardiomegaly. B, Tomographic examination revealed a large, anterior mediastinal mass with fat attenuation interspersed with nodular soft tissue elements (asterisk).

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Thymus

Ströbel¹,

Marx²

2018

Pathologie

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Analysis of outcomes following surgical treatment of thymolipomatous myasthenia gravis: comparison with thymomatous and non-thymomatous myasthenia gravis

Abstract: Our results suggest that patients with myasthenia thymolipomatous have surgical outcomes similar to those of patients with non-thymomatous MG and have a mean age at the time of surgery similar to that of patients with thymomatous MG.

Cited by 13 publications

References 20 publications

Mediastinal Thymolipoma: An Evaluation of the Clinical and Radiological Features and the Surgical Outcomes in 11 Cases

Mediastinal Thymolipoma: An Evaluation of the Clinical and Radiological Features and the Surgical Outcomes in 11 Cases

Fatty Tumor Compressing the Heart

Thymus

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