Analysis of Opisthorchis felineus infection and liver and intrahepatic bile ducts cancer incidence rate in Russian Federation

Сергеевна, Федорова Ольга; Викторовна, Ковширина Юлия; Евгеньевна, Ковширина Анна; Михайловна, Федотова Марина; Анатольевич, Деев Иван; Игоревич, Петровский Федор; Вячеславович, Филимонов Александр; Ивановна, Дмитриева Алла; Александрович, Кудяков Лев; Владимировна, Салтыкова Ирина; Михалев, Е. В.; Питер, Одерматт; Михайловна, Огородова Людмила

doi:10.20538/1682-0363-2016-5-147-158

Cited by 12 publications

(4 citation statements)

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“…Russia has the highest incidence of this helminth. Natural foci of opisthorchiasis are located near the rivers Ob, Irtysh, Urals, Volga, Kama, Don, Dnieper, Severnaya Dvina, and Biryusa [32][33][34][35][36][37][38][39][40][41][42]. The world's largest focus of opisthorchiasis is located in the Ob-Irtysh basin.…”

Section: Discussionmentioning

confidence: 99%

“…The natural foci of opisthorchiasis are adjacent to the Ob, Irtysh, Ural, Volga, Kama, Don, Dnepr, Severnaya Dvina, and Biryusa rivers [32][33][34][35][36][37][38][39][40][41][42].…”

Section: Epidemiology Of Opisthorchiasis In Russiamentioning

confidence: 99%

“…Clinical manifestations of opisthorchiasis are manifold and depend on individual specific features of the host organism as well as infection intensity and duration [34,60,61]. Humans are unable to develop immunity to this pathogen; correspondingly, repeated consumption of the fish carrying metacercariae merely increases invasion [62,63].…”

Section: Clinical Manifestations Pathogenesis and Complications Of mentioning

confidence: 99%

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The World Largest Focus of the Opisthorchiasis in the Ob-Irtysh Basin, Russia, Caused by Opisthorchis felineus

Simakova¹,

Poltoratskaya²,

Babkina³

et al. 2022

Rural Health

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The world's largest focus of opisthorchiasis caused by cat fluke Opisthorchis felineus Rivolta, 1884, is associated with the Ob-Irtysh basin (Russia). The chapter provides data on the history of discovery and the study of opisthorchiasis. Features of the morphology and life cycle of O. felineus are described. Data on the infection of intermediate hosts (mollusks and cyprinids fish) are provided. Species of fish that have important epizootological significance are indicated. The incidence of opisthorchiasis in the people of different age and social groups, clinical manifestations, pathogenesis, and complications is discussed. The climatic and social factors that contribute to maintaining the focus of opisthorchiasis are described. The measures of personal and social prevention of the people are given.

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Section: Discussionmentioning

confidence: 99%

“…The natural foci of opisthorchiasis are adjacent to the Ob, Irtysh, Ural, Volga, Kama, Don, Dnepr, Severnaya Dvina, and Biryusa rivers [32][33][34][35][36][37][38][39][40][41][42].…”

Section: Epidemiology Of Opisthorchiasis In Russiamentioning

confidence: 99%

Section: Clinical Manifestations Pathogenesis and Complications Of mentioning

confidence: 99%

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The World Largest Focus of the Opisthorchiasis in the Ob-Irtysh Basin, Russia, Caused by Opisthorchis felineus

Simakova¹,

Poltoratskaya²,

Babkina³

et al. 2022

Rural Health

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“…However, in sources published in the Russian language, the association between CAA and chronic long-term O . felineus infection has been emphasized [ 7 , 8 ]. In whole, periductal fibrosis is considered an important risk factor for bile duct cancer and is associated with CCA development [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Magnetic resonance imaging and spectroscopy for differential assessment of liver abnormalities induced by Opisthorchis felineus in an animal model

et al. 2017

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BackgroundEuropean liver fluke Opisthorchis felineus, causing opisthorchiasis disease, is widespread in Russia, Ukraine, Kazakhstan and sporadically detected in the EU countries. O. felineus infection leads to hepatobiliary pathological changes, cholangitis, fibrosis and, in severe cases, malignant transformation of bile ducts. Due to absence of specific symptoms, the infection is frequently neglected for a long period. The association of opisthorchiasis with almost incurable bile duct cancer and rising international migration of people that increases the risk of the parasitic etiology of liver fibrosis in non-endemic regions determine high demand for development of approaches to opisthorchiasis detection.Methodology/Principal findingsIn vivo magnetic resonance imaging and spectroscopy (MRI and MRS) were applied for differential assessment of hepatic abnormalities induced by O. felineus in an experimental animal model. Correlations of the MR-findings with the histological data as well as the data of the biochemical analysis of liver tissue were found. MRI provides valuable information about the severity of liver impairments induced by opisthorchiasis. An MR image of O. felineus infected liver has a characteristic pattern that differs from that of closely related liver fluke infections. 1H and 31P MRS in combination with biochemical analysis data showed that O. felineus infection disturbed hepatic metabolism of the host, which was accompanied by cholesterol accumulation in the liver.ConclusionsA non-invasive approach based on the magnetic resonance technique is very advantageous and may be successfully used not only for diagnosing and evaluating liver damage induced by O. felineus, but also for investigating metabolic changes arising in the infected organ. Since damages induced by the liver fluke take place in different liver lobes, MRI has the potential to overcome liver biopsy sampling variability that limits predictive validity of biopsy analysis for staging liver fluke-induced fibrosis.

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Abundance of Opisthorchis felineus Metacercariae in cyprinid fish in the middle Ob River basin (Tomsk region, Russia)

Simakova

Chitnis

Babkina

et al. 2021

Food and Waterborne Parasitology

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Analysis of Opisthorchis felineus infection and liver and intrahepatic bile ducts cancer incidence rate in Russian Federation

Cited by 12 publications

References 1 publication

The World Largest Focus of the Opisthorchiasis in the Ob-Irtysh Basin, Russia, Caused by Opisthorchis felineus

The World Largest Focus of the Opisthorchiasis in the Ob-Irtysh Basin, Russia, Caused by Opisthorchis felineus

Magnetic resonance imaging and spectroscopy for differential assessment of liver abnormalities induced by Opisthorchis felineus in an animal model

Abundance of Opisthorchis felineus Metacercariae in cyprinid fish in the middle Ob River basin (Tomsk region, Russia)

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