Analysis of onset and clinical characteristics in Japanese patients with infantile hemangioma

Hashimoto, Aya; Kunimoto, Kayo; Kawaguchi, Ami; Inaba, Yutaka; Kaminaka, Chikako; Yamamoto, Yuki; Kakimoto, Nobuyuki; Suenaga, Tomohiro; Takeuchi, Takashi; Suzuki, Hiroyuki; Jinnin, Masatoshi

doi:10.5582/ddt.2021.01066

Cited by 6 publications

(10 citation statements)

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“…Alguns estudos mencionam que a lesão presente ao nascimento provavelmente ocorre porque houve um gatilho local, já aquelas que aparecem após o nascimento podem ter sua indução por fatores sistêmicos associados à lesão local, como citocinas relacionadas à neovascularização sistêmica ou crescimento de nervo sensorial após o nascimento (Hashimoto et al, 2021).…”

Section: Resultsunclassified

“…Portanto, há alguns critérios no qual se exige uma terapia sistêmica, como: risco de complicações com risco de vida, quando o hemangioma se localiza em vias aéreas ou quando estiver presente no fígado podendo causar insuficiência cardíaca congestiva; risco de comprometimento funcional, que afeta estruturas envolvidas com a alimentação, visão e audição; presença de ulceração. Portanto, o início oportuno do tratamento na fase proliferativa precoce, idealmente por volta de 1-2 meses de idade, é crítico para evitar danos permanentes à derme e ao tecido subcutâneo (Chang et al, 2008;Chinnadurai et al, 2016;Darrow et al, 2015;Hashimoto et al, 2021;Ishikawa et al, 2020;Jung, 2021;Krowchuk et al, 2019;Olsen et al, 2020;Sampaio et al, 2022;Xu et al, 2020).…”

Section: Resultsunclassified

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Estudo retrospectivo de hemangioma infantil na cavidade bucal na primeira infância

Rezende

Gentile

Corrêa

et al. 2022

RSD

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O hemangioma infantil (HI) é um tumor vascular benigno formado durante a fase embrionária, sendo uma lesão ativa nos primeiros meses de desenvolvimento, depois tende a estacionar, regredir ou até desaparecer. Entretanto, pode resultar em dano tecidual local, quando há ulceração ou sangramento. O objetivo deste trabalho foi estudar, através de um estudo retrospectivo, a prevalência de HI na primeira infância. Foram analisados 93.950 laudos de diagnósticos anatomopatológicos emitidos pelo Laboratório de Patologia Cirúrgica da FOUSP entre os anos de 2000 até 2021. Para esse grupo etário foi encontrando 250 laudos (250/93950; 0.26%), sendo 120 crianças do sexo feminino (120/250, 48%) e 130 crianças do sexo masculino (120/250, 52%). O hemangioma infantil foi encontrado em 3 pacientes (3/250, 1,2%), sendo 2 casos ocorridos em meninos, e um caso em menina. Em relação a localização, dois casos estavam na língua, é um caso no lábio superior. O conhecimento clínico do diagnóstico diferencial do HI é essencial para estabelecer a melhor conduta em cada caso. Raramente estas lesões são submetidas à biópsia, por esta razão a frequência pode ser considerada baixa neste estudo.

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Section: Resultsunclassified

Estudo retrospectivo de hemangioma infantil na cavidade bucal na primeira infância

Rezende

Gentile

Corrêa

et al. 2022

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“…On the other hand, based on above hypothesis, we also tried to confirm that head and neck lesions were more frequent in the group in which infantile hemangioma appeared after birth compared with the patients in which it was present at birth [36]. A slight such tendency was observed, but the difference was not statistically significant.…”

Section: Infantile Hemangiomamentioning

confidence: 86%

ISSVA Classification of Vascular Anomalies and Molecular Biology

Kunimoto

Yamamoto

Jinnin

2022

IJMS

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118

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Vascular anomalies include various diseases, which are classified into two types according to the International Society for the Study of Vascular Anomalies (ISSVA) classification: vascular tumors with proliferative changes of endothelial cells, and vascular malformations primarily consisting of structural vascular abnormalities. The most recent ISSVA classifications, published in 2018, detail the causative genes involved in many lesions. Here, we summarize the latest findings on genetic abnormalities, with the presentation of the molecular pathology of vascular anomalies.

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“…Infantile hemangioma (IH) is a common vascular tumor during infancy caused by endothelial cell (EC) proliferation. 1 It often appears on the head or face at approximately 2 weeks of age. 2 The tumor rapidly proliferates within 6 to 10 months and slowly regresses over several years.…”

Section: Introductionmentioning

confidence: 99%

“…2 The tumor rapidly proliferates within 6 to 10 months and slowly regresses over several years. 1 Although IH is a benign tumor, it can cause facial deformation and vision obstruction and be life-threatening. 3 Thus, studying the mechanisms of IH and finding the appropriate treatment strategies are necessary.…”

Section: Introductionmentioning

confidence: 99%

Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma

et al. 2022

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Objective This study aims to evaluate the expression of interleukin 6 (IL-6) in patients with infantile hemangioma (IH) and investigate the role of the IL-6/signal transducers and activators of transduction-3 (STAT3)/hypoxia-inducible factor-1α (HIF-1α) pathways in the progression of IH. Methods Serum samples were obtained from the patients with IH and normal infants to measure IL-6 expression. Hemangioma-derived stem cells (HemSCs) were transfected with small interfering RNA (siRNA) targeting IL-6, HIF-1α, or STAT3. Then, cell viability and wound healing assays were conducted. After that, the HemSC tumor mouse model was established. The in vivo anticancer effect of the IL-6 inhibitor was investigated. Results The patients with IH had much higher IL-6 levels compared with the healthy controls (p = 0.005). HemSCs transfected with IL-6 siRNA had significantly lower viability and migration rates than normal HemSCs. HemSCs transfected with STAT3 siRNA or HIF-1α siRNA had similar tendencies. On tumor-bearing mice, the IL-6 inhibitor treatment significantly delayed tumor growth. Compared with the control group, caspase-3 was significantly increased in the IL-6 inhibitor group (p < 0.05), whereas Ki-67 was decreased in the IL-6 inhibitor group (p < 0.05). In the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, the IL-6 inhibitor group had much higher apoptosis rates than the controls (p < 0.05). Conclusion Our findings indicate that inhibiting the IL-6/STAT3/HIF-1α signaling pathways could suppress IH growth.

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Analysis of onset and clinical characteristics in Japanese patients with infantile hemangioma

Cited by 6 publications

References 8 publications

Estudo retrospectivo de hemangioma infantil na cavidade bucal na primeira infância

Estudo retrospectivo de hemangioma infantil na cavidade bucal na primeira infância

ISSVA Classification of Vascular Anomalies and Molecular Biology

Inhibiting Interleukin-6/Signal Transducers and Activators of Transduction-3/Hypoxia-Inducible Factor-1α Signaling Pathway Suppressed the Growth of Infantile Hemangioma

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