Analysis of Olig2 and YKL-40 expression: a clinicopathological/immunohistochemical study for the distinction between subventricular zone II and III glioblastomas

Batista, Kmp; Costa, Bal; Pablo, Ica; Vega, Iván Fernández; Morales, J. T. Galán; Álvarez, Ángel Carracedo; Meilán, A.; Astudillo, Aurora; Alvarez, K Y

doi:10.5114/fn.2016.58913

Cited by 5 publications

(4 citation statements)

References 34 publications

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“…Glioma is the most common tumor of the central nervous system [22][23][24], and gliomas are classified as WHO grades I-IV based on tissue classification and staging [25]. In recent decades, despite rapid improvements in the treatment of glioma, the prognosis for glioma patients has remained poor [26].…”

Section: Discussionmentioning

confidence: 99%

Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1

Ren,

Deng,

Xiang

et al. 2024

Aging

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Glioma is the most frequently diagnosed primary brain tumor and typically has a poor prognosis because of malignant proliferation and invasion. It is urgent to elucidate the mechanisms driving glioma tumorigenesis and develop novel treatments to address this deadly disease. Here, we first revealed that PDZK1 is expressed at high levels in gliomas. Promoter hypomethylation may cause high expression of PDZK1 in glioma. Knockdown of PDZK1 inhibits glioma cell proliferation and invasion in vitro. Mechanistically, further investigations revealed that the loss of PDZK1 expression by siRNA inhibited the activation of the AKT/mTOR signaling pathway, leading to cell cycle arrest and apoptosis. Clinically, high expression of PDZK1 predicts a poorer prognosis for glioma patients than low expression of PDZK1. Overall, our study revealed that PDZK1 acts as a novel oncogene in glioma by binding to AKT1 and maintaining the activation of the AKT/mTOR signaling pathway. Thus, PDZK1 may be a potential therapeutic target for glioma.

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Section: Discussionmentioning

confidence: 99%

Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1

Ren,

Deng,

Xiang

et al. 2024

Aging

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“…Several studies have sought to understand the molecular basis for the increased malignancy of glioblastomas with VSVZ contact (17)(18)(19). Two of them demonstrate a correlation with increased glioblastoma expression of CD133, a glioma stem cell marker, with proximity to the VSVZ (20,21).…”

Section: Discussionmentioning

confidence: 99%

Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival

et al. 2020

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ObjectiveTo determine the relationship between survival and glioblastoma distance from the ventricular-subventricular neural stem cell niche (VSVZ).Methods502 pre-operative gadolinium-enhanced, T1-weighted MRIs with glioblastoma retrieved from an institutional dataset (n = 252) and The Cancer Imaging Atlas (n=250) were independently reviewed. The shortest distance from the tumor contrast enhancement to the nearest lateral ventricular wall, the location of the VSVZ, was measured (GBM-VSVZDist). The relationship of GBM-VSVZDist with the proportion of glioblastomas at each distance point and overall survival was explored with a Pearson’s correlation and Cox regression model, respectively, adjusting for the well-established glioblastoma prognosticators.Results244/502 glioblastomas had VSVZ contact. The proportion of non-VSVZ-contacting glioblastomas correlated inversely with GBM-VSVZDist (partial Pearson’s correlation adjusted for tumor volume R=-0.79, p=7.11x10-7). A fit of the Cox regression model adjusted for age at diagnosis, Karnofsky performance status score, post-operative treatment with temozolomide and/or radiotherapy, IDH1/2 mutation status, MGMT promoter methylation status, tumor volume, and extent of resection demonstrated a significantly decreased overall survival only when glioblastoma contacted the VSVZ. Overall survival did not correlate with GBM-VSVZDist.ConclusionsIn the two independent cohorts analyzed, glioblastomas at diagnosis were found in close proximity or in contact with the VSVZ with a proportion that decreased linearly with GBM-VSVZDist. Patient survival was only influenced by the presence or absence of a gadolinium-enhanced glioblastoma contact with the VSVZ. These results may guide analyses to test differential effectiveness of VSVZ radiation in VSVZ-contacting and non-contacting glioblastomas and/or inform patient selection criteria in clinical trials of glioblastoma radiation.

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“…In the adult human brain, the cellular composition and cytoarchitecture of the SVZ is organized into four distinct layers: layer I is found adjacent to the lateral ventricle, and represents a single layer of multi-cialiated ependymal cells; layer II, also known as a hypocellular layer [64], consisting of a diffuse network of a large number of astrocytic, ependymal and neuronal processes, but a few cell bodies; layer III, a strip of astrocytic bodies, and externally, layer IV, adjacent to the brain parenchyma, we find a transition zone composed of many myelin tracts and neuronal bodies (Fig. 2) [25,26,30,38,57]. Interestingly, NSCs, identified as a subpopulation of astrocytes called B1 astrocytes, give rise to actively proliferating transit amplifying progenitors (type C cells), which in turn differentiate into neuroblasts (type A cells) that differentiate into interneurons and eventually migrate toward the olfactory bulb (OB) circuitry, via the rostral migratory stream (RMS), preferentially located in the ventral anterior SVZ of the adult human brain (Fig.…”

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confidence: 81%

“…In the adult human brain, there are a small number of migratory neuroblasts in the SVZ and RMS. Nevertheless, so far there has been no consensus about the exact mechanisms underlying such neural migration toward OB in the adult human SVZ, and also whether there is an RMS [16,57,65]. Although the cytoarchitecture of the adult human SVZ have been characterized, a transcriptional analysis has not been fully established and understood.…”

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confidence: 99%

Mesenchymal/proangiogenic factor YKL-40 related to glioblastomas and its relationship with the subventricular zone

Batista¹,

Eulate-Beramendi²,

Pińa³

et al. 2017

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Analysis of Olig2 and YKL-40 expression: a clinicopathological/immunohistochemical study for the distinction between subventricular zone II and III glioblastomas

Abstract: A b s t r a c t Glioblastomas (GBs) are the most common and lethal primary brain tumors in the adults (HR: 5.86; p = 0.00); radiotherapy (HR: 0.34; p = 0.00); p = 0.0), p = 0.01).

Cited by 5 publications

References 34 publications

Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1

Promoter hypomethylated PDZK1 acts as a tumorigenic gene in glioma by interacting with AKT1

Glioblastoma Distance From the Subventricular Neural Stem Cell Niche Does Not Correlate With Survival

Mesenchymal/proangiogenic factor YKL-40 related to glioblastomas and its relationship with the subventricular zone

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