“…Keyphrases 0 Oxidation-cytochrome P-450, inhibition of in uitro metabolism of aniline and aminopyrine, effect of substituted pyridines on inhibition 0 Aniline-hydroxylase activity, effect of substituted pyridines on in uitro aniline metabolism, cytochrome P-450 oxidation reactions Aminopyrine-demethylation activity, effect of substituted pyridines on in uitro aminopyrine metabolism, cytochrome P-450 oxidation reactions Cytochrome P-450 is the terminal oxygenase responsible for the metabolism of many drugs and xenobiotics. Numerous pyridine-containing compounds such as metyrapone and ellipticine are known to inhibit cytochrome P-450-catalyzed reactions (1,2). It has been suggested that potent inhibitors of cytochrome P-450-catalyzed oxidations may be useful therapeutically in the prevention of chemical-induced cancer (2).…”