Analysis of Normal and Denerved Laryngeal Vocalization in Guinea Pigs (Cavia porcellus)

Arch-Tirado, Emilio; Verduzco-Mendoza, Antonio; Taboada-Picazo, Verónica; Mota-Rojas, Daniel; Alonso-Spilsbury, M.; Alfaro-Rodríguez, Alfonso

doi:10.1016/j.jvoice.2007.03.004

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Laser surgery is a complicated procedure, and surgeons should understand the relation between power density and time of laser use (known as the radiant exposure concept), as well as the concept of lateral thermal spread (8), the most common laser-related complication (8,10,14,55). Lateral thermal spread refers to the increased thermal damage to adjacent tissue with increased laser-tissue contact (8).…”

Section: Laser Precautions and Safetymentioning

confidence: 99%

Use of Lasers in Laryngeal Surgery

et al. 2010

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Lasers are a relatively recent addition to laryngeal surgery. Since their invention, laser use and applications have expanded rapidly. In this paper, we discuss the benefits and disadvantages of lasers for different procedures, as well as ways to overcome commonly faced clinical problems. The use of lasers in surgery has offered a time- and cost-efficient alternative to cold surgical techniques, and has been employed in the treatment of numerous laryngeal pathologies, including stenoses, recurrent respiratory papillomatosis, leukoplakia, nodules, malignant laryngeal disease, and polypoid degeneration (Reinke’s edema). However, lasers can incur adjacent tissue damage and vocal fold scarring. These problems can be minimized through understanding the mechanisms by which lasers function and correctly manipulating the parameters under a surgeon’s control. By varying fluence, power density, and pulsation, tissue damage can be decreased and lasers can be used with greater confidence. The various types of lasers and their applications to the treatment of specific pathologies are reviewed with the intention of helping surgeons select the best tool for a given procedure. Recent applications of lasers to treat benign laryngeal lesions and severe laryngomalacia demonstrate that additional research must be conducted in order to realize the full potential of this surgical tool.

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Section: Laser Precautions and Safetymentioning

confidence: 99%

Use of Lasers in Laryngeal Surgery

et al. 2010

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“…To provide further explanations for the comparability of the measurement results at the triceps brachii and the expected results for the PCA muscle, the physiological functions of the two triceps brachii muscle bellies during rat locomotion are defined in the discussion. The use of the triceps brachii in these experiments is also beneficial due to its accessibility as compared to other possible in vivo animal models, e.g., the analysis of a guinea pig’s larynx [9].…”

Section: Introductionmentioning

confidence: 99%

Comparison between Intramuscular Multichannel Electrodes and Supramysial Multichannel Electrodes via EMG Measurements for Potential Use as Larynx Stimulation Electrodes: In Vivo Animal Analysis

Faenger

Schumann

Anders

et al. 2019

Sensors

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One of the most common causes for larynx paralysis is the injury of the recurrent laryngeal nerve which, among others, causes the paralysis of the posterior cricoarytenoideus muscle (PCA). Electrical stimulation of PCA offers an approach to retaining the function of the paralyzed larynx muscle. The study aim was to test the applicability of an intramuscular multichannel array electrode as a measuring electrode for myoelectrical potentials and as a possible electrode for stimulation, e.g., posterior cricoarytenoideus muscle stimulation. For this purpose, two different kinds of electrodes were compared. 42 intramuscular multichannel array electrodes and 11 supramysial multichannel electrodes were implanted into the triceps brachii muscle of rats. The triceps brachii muscle of rats is suitable to serve as a substitute muscle for the human PCA muscle in an in vivo animal model. It has the same striated muscle cells, is of comparable size, and fundamentally serves a similar function to the human PCA muscle during normal respiration. Walking and breathing are circular functions that cause minimal muscle fatigue when carried out steadily. In total, the myoelectrical activity of 6703 steps could be recorded, allowing a comparison and statistical analysis of the EMG amplitudes and EMG activation patterns. Small differences can be detected between the EMG signals of both electrode types which, however, can be explained physiologically. Both electrode types reveal the basic characteristics of the triceps brachii muscle activity, namely the muscle contraction strength and the coordination pattern. This indicates that the intramuscular electrode may be applied for a detailed analysis of the human larynx.

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The Rat as a Potential Animal Model for Dysphonia

Zolkind¹,

Last²,

Shuminov³

et al. 2013

Otolaryngol.--head neck surg.

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Objectives: Dysphonia, or hoarseness, is the primary complaint of patients with unilateral vocal-fold paralysis due to damage to the recurrent laryngeal nerve (RLN). Animal models for RLN injury exist but are generally limited to histological, endoscopic, and electrophysiological approaches. As a step towards using the rat as a model system for dysphonia, we have characterized ultrasonic vocalizations in healthy adult animals. Methods: Ultrasonic vocalizations were evoked individually from adult male Sprague-Dawley rats by manual stroking on two different days one month apart. The vocalizations were visualized and recorded by using an ultrasound microphone attached to a computer. Parameters such as duration, amplitude, pitch, and entropy were measured for each vocalization as well as the preceding silent period with Sound Analysis Pro 2011 software. Results: For a total of 980 vocalizations from five rats, the following parameter values (mean ± standard deviation) were obtained: duration, 14 ± 10 msec; amplitude, 13 ± 6 relative units; pitch, 57 ± 7 kHz; and entropy, -3.9 ± 1.0. No differences were noticed among animals or days. However, the vocalizations were distinct from the background noise during the preceding silent period: amplitude, -1.4 ± 2.9 relative units; pitch, 42 ± 6 kHz; and entropy, -1.2 ± 0.9. Virtually none of the vocalizations were located in the 20-kHz band associated with distress. Conclusions: Ultrasound vocalizations can be recorded from adult rats easily and reliably. The features of the vocalizations are consistent among individuals and over time. Experiments with RLN-lesioned animals are now underway.

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Analysis of Normal and Denerved Laryngeal Vocalization in Guinea Pigs (Cavia porcellus)

Cited by 4 publications

References 35 publications

Use of Lasers in Laryngeal Surgery

Use of Lasers in Laryngeal Surgery

Comparison between Intramuscular Multichannel Electrodes and Supramysial Multichannel Electrodes via EMG Measurements for Potential Use as Larynx Stimulation Electrodes: In Vivo Animal Analysis

The Rat as a Potential Animal Model for Dysphonia

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