Analysis of new Matrilin-1 gene variants in a case–control study related to dental malocclusions in Equus asinus

Rodrigues, João B.; Araújo, Stéphane; Guedes-Pinto, Henrique; Román, Francisco; Viegas, Carlos; Bastos, Estela

doi:10.1016/j.gene.2013.03.084

Cited by 13 publications

(15 citation statements)

References 23 publications

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“…Statistically significant differences at this variant were found between the control group and the prognathism cases, but not between the control group and the brachygnathism cases [24].…”

Section: Introductionmentioning

confidence: 64%

“…It includes 44 possible positional candidate genes. None of the recently reported candidate genes including MATN1 are located within this region [24]. Thus, the detected association signal on ECA13 suggests that an additional, currently unknown major gene is involved in the genetics of maxillary prognathism.…”

Section: Discussionmentioning

confidence: 87%

“…Thus, the detected association signal on ECA13 suggests that an additional, currently unknown major gene is involved in the genetics of maxillary prognathism. According to our knowledge, the genetics of prognathism in livestock has not yet been investigated in depth, and only markers from candidate gene studies have been reported so far [24]. To our knowledge this is the first genome-wide association analysis for maxillary prognathism in horses.…”

Section: Discussionmentioning

confidence: 99%

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A Chromosomal Region on ECA13 Is Associated with Maxillary Prognathism in Horses

et al. 2014

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Hereditary variations in head morphology and head malformations are known in many species. The most common variation encountered in horses is maxillary prognathism. Prognathism and brachygnathism are syndromes of the upper and lower jaw, respectively. The resulting malocclusion can negatively affect teeth wear, and is considered a non-desirable trait in breeding programs. We performed a case-control analysis for maxillary prognathism in horses using 96 cases and 763 controls. All horses had been previously genotyped with a commercially available 50 k SNP array. We analyzed the data with a mixed-model considering the genomic relationships in order to account for population stratification. Two SNPs within a region on the distal end of chromosome ECA 13 reached the Bonferroni corrected genome-wide significance level. There is no known prognathism candidate gene located within this region. Therefore, our findings in the horse offer the possibility of identifying a novel gene involved in the complex genetics of prognathism that might also be relevant for humans and other livestock species.

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“…Statistically significant differences at this variant were found between the control group and the prognathism cases, but not between the control group and the brachygnathism cases [24].…”

Section: Introductionmentioning

confidence: 64%

Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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A Chromosomal Region on ECA13 Is Associated with Maxillary Prognathism in Horses

et al. 2014

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“…Mandibular teeth become located more rostral than maxillary counterparts, causing malocclusion (Dixon and Dacre, 2005). The event is rare in modern horses, but occurs in some miniature ponies and donkeys; heritable cause has been proposed in the latter instances (Rodrigues et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

A tall rostral hook in a medieval horse premolar tooth

Viranta

Mannermaa

2017

International Journal of Paleopathology

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a b s t r a c tDevelopment of dental abnormalities due to improper occlusal wear is common among modern domestic horses. This phenomenon often is attributed to jaw conformation. Rostral mandibular hooks may develop in horses with underjet or mandibular prognathism, a condition where the lower jaw protrudes forward, beyond the upper jaw. Less abrasive diet, free of phytoliths and matrix-like plant fibers, also may promote enamel and focal overgrowths of equine dentition. Here we report a rostral mandibular hook in a lower premolar tooth of a medieval horse, found in a spring deposit in Levänluhta, Osthrobothnia, Finland. To our knowledge, this is the first such report from a medieval horse.

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“…Also positive associations have been found for genes COL2A1 , MYO1H , TGFB3 , and LTBP2 within the 12q13‐q24 locus. Interestingly, variants in Matn1 (1p35) were associated with mandibular prognathism and anterior cross bites in donkeys .…”

Section: Current Knowledge On the Genetics Of Human Malocclusionmentioning

confidence: 99%

Genetics of the dentofacial variation in human malocclusion

Uribe

Miller

2015

Orthod Craniofacial Res

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Malocclusions affect individuals worldwide, resulting in compromised function and esthetics. Understanding the etiological factors contributing to the variation in dentofacial morphology associated with malocclusions is the key to develop novel treatment approaches. Advances in dentofacial phenotyping, which is the comprehensive characterization of hard and soft tissue variation in the craniofacial complex, together with the acquisition of large-scale genomic data have started to unravel genetic mechanisms underlying facial variation. Knowledge on the genetics of human malocclusion is limited even though results attained thus far are encouraging, with promising opportunities for future research. This review summarizes the most common dentofacial variations associated with malocclusions and reviews the current knowledge of the roles of genes in the development of malocclusions. Lastly, this review will describe ways to advance malocclusion research, following examples from the expanding fields of phenomics and genomic medicine, which aim to better patient outcomes.

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Analysis of new Matrilin-1 gene variants in a case–control study related to dental malocclusions in Equus asinus

Cited by 13 publications

References 23 publications

A Chromosomal Region on ECA13 Is Associated with Maxillary Prognathism in Horses

A Chromosomal Region on ECA13 Is Associated with Maxillary Prognathism in Horses

A tall rostral hook in a medieval horse premolar tooth

Genetics of the dentofacial variation in human malocclusion

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