Abstract:BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and its advanced form, nonalcoholic steatohepatitis (NASH), are prevalent liver diseases with no effective treatment available. NAFLD is marked by increased lipid accumulation in the hepatocytes, lobular inflammation and fibrosis. However, the effects of lipid accumulation in other hepatic lineage cells, such as liver endothelial cells (LEC), intrahepatic cholangiocytes (IHCHOLs), and hepatic stellate cells (HSCs), on NAFLD/NASH progression are less understo… Show more
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