Analysis of Nerve Supply Pattern in Thoracic Duct in Young and Elderly Men

Mignini, Fiorenzo; Sabbatini, Maurizio; Cavallotti, C.; Cavallotti, Carlo

doi:10.1089/lrb.2011.0014

Cited by 13 publications

(17 citation statements)

References 13 publications

(15 reference statements)

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“…Neuropeptide Y (NPY) is a marker for nonadrenergic postganglionic sympathetic fibers, which were observed in the human thoracic duct and mesenteric collecting lymphatics (228, 691, 692). Application of NPY to human thoracic duct rings increased the force of contraction and generally elicited phasic contractions (1059).…”

Section: Lymphangions and The Lymphatic Pump Mechanismmentioning

confidence: 99%

Lymphatic Vessel Network Structure and Physiology

Breslin

Yang

Scallan

et al. 2018

Comprehensive Physiology

267

258

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The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease.

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Section: Lymphangions and The Lymphatic Pump Mechanismmentioning

confidence: 99%

Lymphatic Vessel Network Structure and Physiology

Breslin

Yang

Scallan

et al. 2018

Comprehensive Physiology

267

258

View full text Add to dashboard Cite

show abstract

“…Recently, reduction of nerve supply was also reported for the aged human thoracic duct and other lymphatic vessels. 6,7 In conclusion, the aging-associated changes in structure of the regional lymphatic networks have not been systematically studied, especially with links to the functional status of the aged lymphatic networks.…”

Section: Introductionmentioning

confidence: 99%

Lymphatic Muscle Cells in Rat Mesenteric Lymphatic Vessels of Various Ages

Bridenbaugh

Nizamutdinova

Jupiter

et al. 2013

Lymphatic Research and Biology

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Background: Recent studies on aging-associated changes in mesenteric lymph flow in situ demonstrated predominance of the severe negative chronotropic effect of aging on the contractility of aged mesenteric lymphatic vessels (MLV). At the same time, contraction amplitude of the aged vessels was only slightly diminished by aging and can be rapidly stimulated within 5-15 minutes. However, the detailed quantitative evaluation of potential aging-associated changes in muscle cells investiture in MLV has never been performed. Methods and Results: In this study we, for the first time, performed detailed evaluation of muscle cells investiture in MLV in reference to the position of lymphatic valve in different zones of lymphangion within various age groups (3-mo, 9-mo and 24-mo Fischer-344 rats). Using visual and quantitative analyses of the images of MLV immunohistochemically labeled for actin, we confirmed that the zones located close upstream (pre-valve zones) and above lymphatic valves (valve zones) possess the lowest investiture of lymphatic muscle cells. Most of the high muscle cells investiture zones exist downstream to the lymphatic valve (post-valve zones). The muscle cells investiture of these zones is not affected by aging, while pre-valve and valve zones demonstrate significant aging-associated decrease in muscle cells investiture. Conclusions:The low muscle cells investiture zones in lymphatic vessels consist of predominantly longitudinally oriented muscle cells which are positioned in pre-valve and valve zones and connect adjacent lymphangions. These cells may provide important functional impact on the biomechanics of the lymphatic valve gating and electrical coupling between lymphangions, while their aging-associated changes may delimit adaptive reserves of aged lymphatic vessels.

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“…; Mignini et al. ; Kammerer et al. ), although the relation between age and diameter has been disputed (Seeger et al.…”

Section: Resultsmentioning

confidence: 99%

The anatomy and physiology of the terminal thoracic duct and ostial valve in health and disease: potential implications for intervention

et al. 2018

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The thoracic duct (TD) transports lymph drained from the body to the venous system in the neck via the lymphovenous junction. There has been increased interest in the TD lymph (including gut lymph) because of its putative role in the promotion of systemic inflammation and organ dysfunction during acute and critical illness. Minimally invasive TD cannulation has recently been described as a potential method to access TD lymph for investigation. However, marked anatomical variability exists in the terminal segment and the physiology regarding the ostial valve and terminal TD is poorly understood. A systematic review was conducted using three databases from 1909 until May 2017. Human and animal studies were included and data from surgical, radiological and cadaveric studies were retrieved. Sixty-three articles from the last 108 years were included in the analysis. The terminal TD exists as a single duct in its terminal course in 72% of cases and 13% have multiple terminations: double (8.5%), triple (1.8%) and quadruple (2.2%). The ostial valve functions to regulate flow in relation to the respiratory cycle. The patency of this valve found at the lymphovenous junction opening, is determined by venous wall tension. During inspiration, central venous pressure (CVP) falls and the valve cusps collapse to allow antegrade flow of lymph into the vein. During early expiration when CVP and venous wall tension rises, the ostial valve leaflets cover the opening of the lymphovenous junction preventing antegrade lymph flow. During chronic disease states associated with an elevated mean CVP (e.g. in heart failure or cirrhosis), there is a limitation of flow across the lymphovenous junction. Although lymph production is increased in both heart failure and cirrhosis, TD lymph outflow across the lymphovenous junction is unable to compensate for this increase. In conclusion the terminal TD shows marked anatomical variability and TD lymph flow is controlled at the ostial valve, which responds to changes in CVP. This information is relevant to techniques for cannulating the TD, with the aid of minimally invasive methods and high resolution ultrasonography, to enable longitudinal physiology and lymph composition studies in awake patients with both acute and chronic disease.

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Analysis of Nerve Supply Pattern in Thoracic Duct in Young and Elderly Men

Cited by 13 publications

References 13 publications

Lymphatic Vessel Network Structure and Physiology

Lymphatic Vessel Network Structure and Physiology

Lymphatic Muscle Cells in Rat Mesenteric Lymphatic Vessels of Various Ages

The anatomy and physiology of the terminal thoracic duct and ostial valve in health and disease: potential implications for intervention

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