Analysis of natural killer activity and natural killer cell subsets in patients with bladder cancer

Abstract

In order to analyze the state of the natural resistance system of bladder cancer patients in vivo, we measured natural killer (NK) activity and NK cell subsets of peripheral blood lymphocytes (PBL) from 46 patients with bladder cancer and 25 age- and sex-matched healthy volunteers. The mean NK activity in patients with low-stage bladder cancer was similar to that in the controls, while NK activity in patients with high-stage bladder cancer was significantly depressed. The mean proportions of Leu7+ cells in patients with both low-stage and high-stage bladder cancer were significantly higher than that in the controls. The mean proportion of Leu11 a+ cells in patients with low-stage bladder cancer was similar to that in the controls, while in patients with high-stage bladder cancer it was significantly higher. This study demonstrates the abnormal immunological state of bladder cancer patients: namely, abnormalities exist not only in NK activity but also in the proportions of circulating NK cell subsets.

The association between the recurrence of solitary non-muscle invasive bladder cancer and tumor infiltrating lymphocytes

“…They hypothesized that unfavorable prognosis related to the presence of TILs may be connected to the inhibitory mediators released by the tumor cells. These results are in contrast to the findings obtained by other authors, who reported good prognosis for the patients with higher number of TILs (23-25). …”

Effect of Oral Administration ofButyrivibrio fibrisolvensMDT-1, a Gastrointestinal Bacterium, on 3-Methylcholanthrene-Induced Tumor in Mice

“…Delayed onset may result from reduced exposure to carcinogenic factors in the diet or lifestyle changes or by using chemopreventive agents that inhibit carcinogen uptake, maintain tumor suppressor function, or modulate immune responses. Increased immune responses have been reported in patients with cancer (6)(7)(8)(9), and patients that relapse have significantly lower preoperative NK cytotoxicity than relapse-free patients (10). These observations indicate that NK cells are candidates for cells that destroy tumor cells and that they may function as the first line in host defense against tumorigenesis.…”

An essential role for decorin in bladder cancer invasiveness

“…Several studies have demonstrated the presence of large amounts of tumour infiltrating lymphocytes (TILs) in both muscle-invasive and superficial bladder tumours. Most of these data have correlated higher numbers of TILs with a good prognosis and survival rate (Ikemoto et al, 1990;Lopez-Beltran et al, 1989;Morita et al, 1990;Tsujihashi et al, 1988) especially in patients with advanced stages of tumour development (Lipponen et al, 1992;Sharma et al, 2007). These TILs are functional and can kill their autologous tumour in vitro (Housseau et al, 1997).…”