Analysis of nasal air conditioning in subjects with unilateral cleft lip nasal deformity

Li, Hang; Martin, H; Marcus, Jeffrey R.; Frank‐Ito, Dennis O.

doi:10.1016/j.resp.2021.103694

Cited by 7 publications

(2 citation statements)

References 65 publications

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Section: Discussionmentioning

confidence: 99%

“…The undeniable power of CFD modeling has been utilized by our group for over a decade to provide highly important insights into identification of specific variables that correlate with patient-reported symptoms of nasal obstruction [36][37][38][39] ; race and gender differences on nasal respiratory physiology 25,[40][41][42] ; and analyzing the nasal function of patients with uCLND. [17][18][19]43 Airflow streamlines in Figure 4 depict patent regions of the nasal airway with dominant airflow access before and after surgery. Notice that the regions where nasal airflow had easy access corresponded to anatomical sites that were not identified as greatest obstructive sites in Figure 6.…”

Section: Discussionmentioning

confidence: 99%

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Nasal Airflow Dynamics Before and After Septorhinoplasty for Correction of Cleft Lip Nasal Deformity: A Single Patient Case Report

Gosman

Marcus

Frank‐Ito

2023

FACE

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Background: Unilateral cleft lip nasal deformity (uCLND) creates multiple sites of nasal airway obstruction, impacting patients’ quality of life. Surgical restoration of function remains technically challenging and complex. Objectives: This is a single patient case report to determine consistency of patient’s subjective perception of nasal outcomes after septorhinoplasty with objective assessments, and effectiveness of standard surgical techniques in targeting sites of greatest nasal anatomical obstruction. Method: Patient-reported quality of life (QOL) measures were collected. Pre- and post-surgery radiographic images of a patient with uCLND were obtained for computational fluid dynamics (CFD) modeling of patient-specific nasal function. Objective assessments were obtained using rhinomanometry and CFD. CFD-derived localized resistance at multiple cross-sectional segments were determined and used to identify greatest nasal obstructive sites. Results: Patient-reported QOL scores improved by 20 to 73 points. CFD-calculated bilateral resistance decreased from 0.155 to 0.061 Pa.s/ml, cleft-side resistance from 0.407 to 0.091 Pa.s/ml, and non-cleft-side from 0.228 to 0.120 Pa.s/ml. Rhinomanometry showed similar decreases in resistance. On the cleft side, 25 identified sites of greatest obstruction decreased to 15 sites post-surgery; on the non-cleft side, 23 sites of greatest obstruction decreased to 16 sites post-surgery. Conclusion: Results suggest improvement in nasal patency after septorhinoplasty. Additional greatest obstructive sites in the post-surgical airway were mostly around the superior airway.

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