Analysis of naming processing stages in patients with mild Alzheimer

Moayedfar, Saeideh; Purmohammad, Mehdi; Shafa, Nita; Shafa, Nina; Ghasisin, Leila

doi:10.1080/23279095.2019.1599894

Cited by 8 publications

(6 citation statements)

References 34 publications

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“…Although confrontation naming fundamentally relies on the knowledge-semantic store, it also depends on intact attention and perceptual processing as well as activation of the appropriate semantic associations ( Rohrer et al., 2007 ). In cases of mild AD, picture naming decline (non-response or false responses) has been mostly attributed conceptual degradation (difficulty in accessing the meaning of words) and impaired phonemic encoding ( Moayedfar, Purmohammad, Shafa, Shafa, & Ghasisin, 2019 ) while high-frequency (commonly encountered) and early acquired objects tend to be more resistant to anomia ( Cuetos, Rodríguez-Ferreiro, Sage, & Ellis, 2012 ). Verbal comprehension and repetition deficits usually coexist with word-finding difficulties since they likewise depend on semantic knowledge (especially verbal comprehension) and attention-perceptual functions (especially repetition) as well as the ability to coordinate verbal input and output pathways ( Rohrer et al., 2007 ).…”

Section: Discussionmentioning

confidence: 99%

Language Differences Among Individuals with Normal Cognition, Amnestic and Non-Amnestic MCI, and Alzheimer’s Disease

Liampas

Folia

Morfakidou

et al. 2022

Archives of Clinical Neuropsychology

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Objective To investigate differences in language performance among older adults with normal cognition (CN), mild cognitive impairment (MCI), and Alzheimer’s disease (ad). Owing to the conflicting literature concerning MCI, discrepancies between amnestic (aMCI) and non-amnestic MCI (naMCI) were explored in greater detail. Method The study sample was drawn from the older (>64 years) HELIAD cohort. Language performance was assessed via semantic and phonemic fluency, confrontation naming, verbal comprehension, verbal repetition as well as a composite language index. Age, sex, and education adjusted general linear models were used to quantify potential pairwise differences in language performance. Results The present analysis involved 1607 participants with CN, 146 with aMCI [46 single and 100 multi-domain aMCI], 92 with naMCI [41 single and 51 multi-domain naMCI], and 79 with ad. The mean age and education of our predominantly female (60%) participants were 73.82 (±5.43) and 7.98 (±4.93) years, respectively. MCI individuals performed between those with CN and ad, whereas participants with aMCI performed worse compared to those with naMCI, especially in the semantic fluency and verbal comprehension tasks. Discrepancies between the aMCI and naMCI groups were driven by the exquisitely poor performance of multi-domain aMCI subgroup. Conclusions Overall, individuals could be hierarchically arranged in a continuum of language impairment with the CN individuals constituting the healthy reference and naMCI, aMCI, ad patients representing gradually declining classes in terms of language performance. Exploration of language performance via separation of single from multi-domain naMCI provided a potential explanation for the conflicting evidence of previous research.

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Section: Discussionmentioning

confidence: 99%

Language Differences Among Individuals with Normal Cognition, Amnestic and Non-Amnestic MCI, and Alzheimer’s Disease

Liampas

Folia

Morfakidou

et al. 2022

Archives of Clinical Neuropsychology

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“…Participants were required to do grammatical judgment within 5000 milliseconds. If a person’s grammatical judgment lasted more than 5,000 milliseconds, it was considered as “no response”, however, the no response was also taken into account in calculating the reaction time [ 59 ]. In this study, the mean reaction time in normal aged group was 1644 milliseconds, and 2315 milliseconds in AD patients.…”

Section: Discussionmentioning

confidence: 99%

Investigating sentence processing and working memory in patients with mild Alzheimer and elderly people

Nasiri

Moayedfar²,

Purmohammad³

et al. 2022

PLoS ONE

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Introduction Linguistic disorders are one of the common problems in Alzheimer’s disease, which in recent years has been considered as one of the key parameters in the diagnosis of Alzheimer (AD). Given that changes in sentence processing and working memory and the relationship between these two activities may be a diagnostic parameter in the early and preclinical stages of AD, the present study examines the comprehension and production of sentences and working memory in AD patients and healthy aged people. Methods Twenty-five people with mild Alzheimer’s and 25 healthy elderly people participated in the study. In this study, we used the digit span to evaluate working memory. Syntactic priming and sentence completion tasks in canonical and non-canonical conditions were used for evaluating sentence production. We administered sentence picture matching and cross-modal naming tasks to assess sentence comprehension. Results The results of the present study revealed that healthy elderly people and patients with mild Alzheimer’s disease have a significant difference in comprehension of relative clause sentences (P <0.05). There was no significant difference between the two groups in comprehension of simple active, simple active with noun phrase and passive sentences (P> 0.05). They had a significant difference in auditory and visual reaction time (P <0.05). Also there was a significant difference between the two groups in syntactic priming and sentence completion tasks. However, in non-canonical condition of sentence completion, the difference between the two groups was not significant (P> 0.05). Conclusion The results of the present study showed that the mean scores related to comprehension, production and working memory in people with mild Alzheimer’s were lower than healthy aged people, which indicate sentence processing problems at this level of the disease. People with Alzheimer have difficulty comprehending and producing complex syntactic structures and have poorer performance in tasks that required more memory demands. It seems that the processing problems of these people are due to both working memory and language problems, which are not separate from each other and both are involved in.

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“…The clinical phenotype of Alzheimer’s disease (AD), being the most common cause of dementia, includes dysnomia. Dysnomia refers to the impairment of naming capacity (Moayedfar et al 2021 ; Georgiou et al 2022 ). Gradual progressive impairment in lexical retrieval is one of the main symptoms of the early stages of AD, which also encompass decline in memory, attention/concentration, orientation, visuospatial abilities and executive function (Jokel et al 2019 ; Jarema et al 2020 ; Moayedfar et al 2021 ; Knopman et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

“…Dysnomia refers to the impairment of naming capacity (Moayedfar et al 2021 ; Georgiou et al 2022 ). Gradual progressive impairment in lexical retrieval is one of the main symptoms of the early stages of AD, which also encompass decline in memory, attention/concentration, orientation, visuospatial abilities and executive function (Jokel et al 2019 ; Jarema et al 2020 ; Moayedfar et al 2021 ; Knopman et al 2021 ). In moderate to severe stages of major neurocognitive disorder (MajorND) due to AD, deficits in verbal fluency, comprehension and literal and semantic paraphrases become prominent, while in very severe AD speech can be restricted to echolalia and verbal stereotypy (Ferris and Farlow 2013 ; Sachdev et al 2014 ).…”

Section: Introductionmentioning

confidence: 99%

Validation of the test for finding word retrieval deficits (WoFi) in detecting Alzheimer's disease in a naturalistic clinical setting

Georgiou,

Skondra,

Charalampopoulou

et al. 2023

Eur J Ageing

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Background Detecting impaired naming capacity contributes to the detection of mild (MildND) and major (MajorND) neurocognitive disorder due to Alzheimer’s disease (AD). The Test for Finding Word retrieval deficits (WoFi) is a new, 50-item, auditory stimuli-based instrument. Objective The study aimed to adapt WoFi to the Greek language, to develop a short version of WoFi (WoFi-brief), to compare the item frequency and the utility of both instruments with the naming subtest of the widely used Addenbrooke’s cognitive examination III (ACEIIINaming) in detecting MildND and MajorND due to AD. Methods This cross-sectional, validation study included 99 individuals without neurocognitive disorder, as well as 114 and 49 patients with MildND and MajorND due to AD, respectively. The analyses included categorical principal components analysis using Cramer’s V, assessment of the frequency of test items based on corpora of television subtitles, comparison analyses, Kernel Fisher discriminant analysis models, proportional odds logistic regression (POLR) models and stratified repeated random subsampling used to recursive partitioning to training and validation set (70/30 ratio). Results WoFi and WoFi-brief, which consists of 16 items, have comparable item frequency and utility and outperform ACEIIINaming. According to the results of the discriminant analysis, the misclassification error was 30.9%, 33.6% and 42.4% for WoFi, WoFi-brief and ACEIIINaming, respectively. In the validation regression model including WoFi the mean misclassification error was 33%, while in those including WoFi-brief and ACEIIINaming it was 31% and 34%, respectively. Conclusions WoFi and WoFi-brief are more effective in detecting MildND and MajorND due to AD than ACEIIINaming.

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Analysis of naming processing stages in patients with mild Alzheimer

Cited by 8 publications

References 34 publications

Language Differences Among Individuals with Normal Cognition, Amnestic and Non-Amnestic MCI, and Alzheimer’s Disease

Language Differences Among Individuals with Normal Cognition, Amnestic and Non-Amnestic MCI, and Alzheimer’s Disease

Investigating sentence processing and working memory in patients with mild Alzheimer and elderly people

Validation of the test for finding word retrieval deficits (WoFi) in detecting Alzheimer's disease in a naturalistic clinical setting

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