Analysis of MTHFR polymorphisms and P16 methylation and their correlation with clinical–biological features of multiple myeloma

Abstract

Our data demonstrated that variant alleles did not play a key role neither in protection nor in increased risk for MM, suggesting that the effect of MTHFR on folate metabolism might be modified by diet intake. Moreover, our findings demonstrated that p16 hypermethylation might be a frequent genetic aberration in MM and may contribute with other molecular aberrations in the pathogenesis of this malignant disorder.

Association of folate transporter SLC19A1 polymorphisms with the outcome of multiple myeloma after chemotherapy and tandem autologous transplantation

“…In particular, p16 hypermethylation, seemed to play a role in pathogenesis of myeloma and, for some authors, in overall survival. 8 In any case, further analyses must be performed to confirm our preliminary data. This is the first report demonstrating a predictive value of SLC19A1 genotypes for the outcome of DAV regimen followed by autologous transplantation in MM patients.…”

“…DMAT has the lowest K(i) value of all known CK2 inhibitors, and is cell permeable. 8 Based on reported ranges of efficacy, 7,8 DMAT was tested at 5, 10 and 20 mM. We used the previously described PLC1 cell line, which was established from a P190 Bcr/Abl transgenic mouse that developed pro/pre-B lymphoblastic leukemia/lymphoma.…”

Genetics and molecular epidemiology of multiple myeloma: The rationale for the IMMEnSE consortium (Review)

“…MTHFR, which has been found associated with cancer risk (108,109), is one of the most important enzymes involved in the regulation of folate homeostasis. Two MTHFR missense SNPs, C677T (rs1801133) and A1298C (rs1801131), were investigated in relation to MM susceptibility in various reports with evidence for association (110)(111)(112) as well as for no association (113)(114)(115)(116)(117). Recently, a meta-analysis confirmed a possible role for the MTHFR C677T (rs1801133) SNP in MM susceptibility, with an increased risk for carriers of the 677T allele (118).…”

The role of MTHFR gene in multiple myeloma

“…Controls were reported to be age, sex or ethnicity matched in three studies (Chiusolo et al 2006;Gonzalez Ordonez et al 2000;Gonzalez-Fraile et al 2002). Four studies involved Caucasians (Chiusolo et al 2006;Gonzalez Ordonez et al 2000;Gonzalez-Fraile et al 2002;Lincz et al 2003), two studies involved East Asians Moon et al 2007), and one study involved mixed population (Lima et al 2007). The cases were well defined with similar inclusion criteria, although they unavoidably cover a wide spectrum of disease, in terms of clinico-laboratory data and molecular subtypes.…”

“…The literature review identified nine titles in PubMed that met the search criteria (Lima et al 2007;Chiusolo et al 2006;Moon et al 2007;Chen et al 2006;Gonzalez Ordonez et al 2000;Gonzalez-Fraile et al 2002;Lincz et al 2003;Yanamandra et al 2003). The full articles were analyzed to assess their appropriateness for metaanalysis.…”