Analysis of motoneuron responses to composite synaptic volleys (computer simulation study)

Piotrkiewicz, Maria; Kudina, Lydia P.

doi:10.1007/s00221-011-2987-2

Cited by 4 publications

(3 citation statements)

References 48 publications

(86 reference statements)

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“…Recently, however, Piotrkiewicz and Kudina (2012) put forward that not all increases in the discharge rates could indicate excitation. Using simulation studies and very short-lasting EPSPs, they showed that the pulse-like EPSPs prefer slower discharging phases of a unit and hence effectively separate the higher discharge rate events from the lower discharge rate events.…”

Section: Limitations Of Studymentioning

confidence: 99%

Human stretch reflex pathways reexamined

Yavuz

Mrachacz-Kersting

Sebik

et al. 2014

Journal of Neurophysiology

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responses of tibialis anterior motor units to stretch stimuli were investigated in human subjects. Three types of stretch stimuli were applied (tap-like, ramp-and-hold, and half-sine stretch). Stimulus-induced responses in single motor units were analyzed using the classical technique, which involved building average surface electromyogram (SEMG) and peristimulus time histograms (PSTH) from the discharge times of motor units and peristimulus frequencygrams (PSF) from the instantaneous discharge rates of single motor units. With the use of SEMG and PSTH, the tap-like stretch stimulus induced five separate reflex responses, on average. With the same single motor unit data, the PSF technique indicated that the tap stimulus induced only three reflex responses. Similar to the finding using the tap-like stretch stimuli, ramp-and-hold stimuli induced several peaks and troughs in the SEMG and PSTH. The PSF analyses displayed genuine increases in discharge rates underlying the peaks but not underlying the troughs. Half-sine stretch stimuli induced a long-lasting excitation followed by a long-lasting silent period in SEMG and PSTH. The increase in the discharge rate, however, lasted for the entire duration of the stimulus and continued during the silent period. The results are discussed in the light of the fact that the discharge rate of a motoneuron has a strong positive linear association with the effective synaptic current it receives and hence represents changes in the membrane potential more directly and accurately than the other indirect measures. This study suggests that the neuronal pathway of the human stretch reflex does not include inhibitory pathways.

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Section: Limitations Of Studymentioning

confidence: 99%

Human stretch reflex pathways reexamined

Yavuz

Mrachacz-Kersting

Sebik

et al. 2014

Journal of Neurophysiology

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“…Although PSF method is found to be less prone to count and synchronization type errors, it is not efficient for indicating the latency of inhibitory responses as well as small but genuine responses (Piotrkiewicz and Kudina 2012). This is due to the fact that in the beginning of an inhibitory response the spike occurrences are delayed, and hence no spikes are available to determine discharge rate.…”

Section: Discussionmentioning

confidence: 98%

Reflex responses of human masseter motor units to mechanical stimulation of the teeth

Uginčius

Atış

Türker

2014

Journal of Neurophysiology

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Our aim was to investigate the jaw reflexes using both the probability- and the discharge rate-based analysis methods. Twelve consenting volunteer subjects participated in this study. Subjects bit gently on bite bars that carried the impression of their teeth. Surface and intramuscular electrical activity of the masseter was recorded. With the help of audio feedback from one motor unit, each subject bit to discharge the unit at a fixed rate. While the subject continuously activated the selected motor unit, 4-N stimuli were delivered to the upper right central incisor either at a rapid or a slow rate. For each trial, ≥300 stimuli were delivered, and, once a trial was completed, local anesthetic block was applied around the stimulated tooth, and the experiment was repeated. While preceding local anesthesia, the rapid-rate stimuli ("tap") induced substantial inhibitory reflex responses; during local anesthetic block, the same stimulus induced excitatory and inhibitory reflex responses. Slow-rate stimuli ("push"), on the other hand, usually generated a combination of inhibitory and excitatory responses that disappeared completely during the local anesthetic block. This study discovered that the strength of the inhibitory reflex response to a tooth-tap stimulus was much larger than previously reported. This study also found that whereas the probability-based analyses were better for illustrating the existence and latency of small earlier responses, the discharge rate-based method was better for indicating the duration of earlier responses and the existence, sign, and duration of later responses.

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“…To overcome this difficulty, we developed the method that we called “gap filling.” It is explained here on the examples from computer simulations based on the simple threshold-crossing model described elsewhere (Piotrkiewicz, 1999 ; Piotrkiewicz and Kudina, 2012 ). The model was verified by comparison with results of several human experiments (Kuraszkiewicz et al, 2012 ).…”

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confidence: 99%