Analysis of Mortality in Patients With COVID-19: Clinical and Laboratory Parameters

Abstract

Background Several reports on epidemiological and clinical features of the 2019 coronavirus disease (COVID-19) have been published. However, mortality and morbidity analyses, important for better understanding the pathogenesis of this disease, are scarce. We examine the clinical and laboratory features of 14 patients who died of COVID-19. Methods The cohort consisted of 11 male and 3 female patients, with 9 patients aged 70 years or above, and nearly all had underlying diseases. Results Fever with bilateral pneumonia was the main manifestation. Most patients had consolidations combined with ground glass opacity (GGO) on chest computed tomography scan. Laboratory tests showed lymphocytopenia in 10 patients, high blood glucose in 11, GGT in 5 of the 14 patients, and high LDH in 5 of 6 patients tested. In addition, this cohort had high level of cytokines such as interleukin-6 in all 8 patients tested. Conclusions The clinical and laboratory parameters in the cohort of fatal cases may be incorporated into future clinical prognosis models and will be of help in understanding the pathogenesis of this disease.

Heterogeneous expression of the SARS-Coronavirus-2 receptor ACE2 in the human respiratory tract

“…Independent risk factors associated with severe COVID-19 include male sex, increased age, and presence of comorbidities [ 6 , [8] , [9] , [10] , [36] , [37] , [38] ]. To evaluate whether the spatial distribution and abundance of ACE2 protein in the lower respiratory tract differed by these risk factors, we scored tissues for ACE2 protein detection ( Supplemental Table 2 ).…”

Bleeding and Bleeding Risk in COVID-19

“…15 Another study analyzing mortality revealed that 1 ($7%) out of 14 patients died due to GI bleeding. 16 It is worth noting, however, that the patient had lymphoma, thus comorbidities may represent a part of the risk profile.…”

Breve Cenário Da Covid-19 E Suas Repercussões Na Saúde Pública: Justificando a Obra

“…Foi possível verificar neste estudo que a redução de linfócitos (linfocitopenia) foi a alteração laboratorial mais frequente, em consonância com descobertas da literatura (LU;FU et al, 2020;ZHENG et al, 2020;LI LONG-QUAN et al, 2020;TIAN et al, 2020;AGGARWAL et al, 2020;WEI et al, 2020;LI YANLEI et al, 2020), podendo ser utilizada como um índice de referência de diagnóstico clínico da COVID-19 (LI LONG-QUAN et al, 2020). A linfocitopenia pode ser explicada através de mecanismos distintos.…”

“…A atrofia do tecido hematopoiético da medula óssea foi observada na SARS e na COVID-19 (TIAN et al, 2020). Segundo o tratamento com glicocorticóides pode induzir linfocitopenia em alguns pacientes (TIAN et al, 2020).…”

“…A redução de linfócitos do tipo T CD4 e CD8 também foi descrita em pacientes com infecção por COVID-19 (WEI et al, 2020;TIAN et al, 2020;ZHENG et al, 2020). Sugere-se que a SARS-CoV-2 afeta primeiramente os linfócitos T, especialmente as células T CD4, resultando em linfopenia significativa com diminuição na produção de interferon (FU et al, 2020).…”