Analysis of Mortality from Asbestos-Related Diseases in Brazil Using Multiple Health Information Systems, 1996–2017

Eduardo, A.L.G.R.A.N.T.I.; Vilma, S. SANTANA; Felipe, C.A.M.P.O.S.; Salvi, Leonardo; Saito, Cézar Akiyoshi; Franciana, C.A.V.A.L.C.A.N.T.E.; Heleno, R. CORREA-FILHO

doi:10.1016/j.shaw.2022.04.006

Cited by 7 publications

(5 citation statements)

References 28 publications

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“…The incidence rates of MM in Australia have stabilized over the first decade of the 21st century (2.8 per 100,000 in 2011) [60]. According to a research, the crude mesothelioma mortality rate has been rising in Brazil for both males and females and it's important to mention that Brazil was one of the top four asbestos producers in 2020 [61].…”

Section: Discussionmentioning

confidence: 99%

Asbestos ban policies and mesothelioma mortality in Greece

Gogou,

Hatzoglou,

Siachpazidou

et al. 2024

BMC Public Health

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Background Malignant mesothelioma is a rare form of cancer that mostly affects the pleura and has a strong link to asbestos exposure. Greece banned the use of asbestos in 2005, however, the public was already aware of this substance in the 1980s. This research aims to present an overview of Greece’s mesothelioma age-standardized mortality rates (ASMR) from 1983 to 2019 by age, gender, and geographic region and to determine whether the actions to ban asbestos impacted these rates. Methods Data were retrieved by the Hellenic Statistical Authority (HSA) from death certificates that mentioned mesothelioma as the cause of death from 1983 to 2019 with details on the residence, gender, and age. Statistical analysis was performed using PRISM 6.0 software, a two-way ANOVA test, Trend analysis was conducted using Joinpoint Regression Program 5.0 software. The linear and non-linear model was used to calculate the age-standardized rates of annual percentage change (APC) and its 95% confidential interval (95% CI). Results From 1983 to 2019, 850 total mesothelioma deaths were recorded, the majority of whom were males (634). A rate of 74.6% accounts for males and 25.4% for females, and the ratio of Males: Females was 3:1. Males’ ASMR and the whole population’s ASMR reached their highest levels in 2011 (0.93/100000person-years and 0.53/100000person-years, respectively). To look for potential changes between the first two decades of the 21st century, we compared the mean ASMR of each geographic region in Greece between two different 10-year subperiods (2000–2009 and 2010–2019). Except for Epirus, all regions of Greece had elevated regional ASMRs, particularly in those with the highest asbestos deposits. Notably, the ASMR in Epirus decreased from 0.54/100000person-years (2000–2009) to 0.31/100000person-years (2010–2019). After 2011, the ASMR for men and the general population stabilized. This stability is important since mesothelioma in men is associated with occupational asbestos exposure. The intriguing discovery of a lower ASMR in Epirus emphasizes the need to raise awareness of the condition and implement effective public health measures. Conclusions In Greece, the annual ASMR for males and the whole population reached its highest level in 2011, which is positive and encouraging and may be a sign that the rate will stabilize during the following years. Moreover, this study showed that the actions made in the 1980s regarding public awareness and surveillance directly impacted the decrease in Epirus rates. Future research, continual awareness, information, and recording are needed to monitor the mesothelioma epidemic. The possible benefit of a mesothelioma registry and the epidemiological surveillance of asbestos-related diseases, particularly mesothelioma mortality, need to be addressed. Trial registration Not applicable.

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Section: Discussionmentioning

confidence: 99%

Asbestos ban policies and mesothelioma mortality in Greece

Gogou,

Hatzoglou,

Siachpazidou

et al. 2024

BMC Public Health

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“…The incidence rates of MM in Australia have stabilized over the rst decade of the 21st century (2.8 per 100,000 in 2011) (34). According to a research, the crude mesothelioma mortality rate has been rising in Brazil for both males and females and it's important to mention that Brazil was one of the top four asbestos producers in 2020 (35).…”

Section: Discussionmentioning

confidence: 99%

Asbestos Ban Policies and Mesothelioma Mortality in Greece

Gogou,

Hatzoglou,

Siachpazidou

et al. 2023

Preprint

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Background Malignant mesothelioma is a rare form of cancer that mostly affects the pleura and has a strong link to asbestos exposure. Greece banned the use of asbestos in 2005, however, the public was already aware of this substance in the 1980s. This research aims to present an overview of Greece's mesothelioma mortality rates (MMR) from 1983 to 2019 by age, gender, and geographic region and to determine whether the actions to ban asbestos impacted these rates. Methods Data were retrieved by the Hellenic Statistical Authority (HAS) from death certificates that mentioned mesothelioma as the cause of death from 1983 to 2019 with details on the residence, gender, and age. Statistical analysis was performed using SPSS 29 software, a one-way ANOVA test followed by post-hoc and Dunnett C test for multiple comparisons or Independent samples T-test for comparison between two subjects. Results Males' MMR and the whole population's MMR reached their highest levels in 2011 (0.86/100000 and 0.52/100000, respectively). In order to look for any potential changes between the first two decades of the 21st century, we compared the mean MMR of each geographic region in Greece between two different 10-year subperiods (2000–2009 and 2010–2019). Except for Epirus, all regions of Greece had elevated regional MMRs, particularly in those with the highest asbestos deposits. Notably, the MMR in Epirus decreased from 0.55/100000 (2000–2009) to 0.38/100000 (2010–2019). After 2011, the MMR for men and the general population stabilized. This stability is important since mesothelioma in men is associated with occupational asbestos exposure. The intriguing discovery of a lower MMR in Epirus emphasizes the need to raise awareness of the condition and implement effective public health measures. Conclusions In Greece, the annual rate for males and the whole population reached its highest level in 2011, which is positive and encouraging and may be a sign that the rate will stabilize during the following years. Moreover, this study showed that the actions made in the 1980s regarding public awareness and surveillance directly impacted the decrease in Epirus rates. Future research, continual awareness, information, and recording are needed to monitor the mesothelioma epidemic. Trial registration: Not applicable

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“…(6) In Brazil, by linking five health information systems between 1996 and 2017, 2,405 MM-related deaths (as the underlying or the contributing cause of death) were retrieved, of which 74.7% were pleural or unspecified and 17.3% were peritoneal. (7) Since the 1960s, approximately 9 million tons of chrysotile and small amounts of anthophyllite were produced and about 7 million tons of asbestos were consumed in Brazil. (8) The production and consumption of asbestoscontaining products were mostly concentrated in the southeastern region of the country, particularly in the state of São Paulo.…”

Section: Introductionmentioning

confidence: 99%

Identifying malignant mesothelioma by a pathological survey using the São Paulo state hospital cancer registry, Brazil

Del Carlo Bernardi 1,

Algranti2,

Dolhnikoff3

et al. 2024

J Bras Pneumol.

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Objective: To review the pathological diagnosis of possible cases and/or hidden cases of malignant mesothelioma (MM) between 2000 and 2012 using the Hospital-Based Cancer Registry database in the state of São Paulo, Brazil. Methods: Possible cases were retrieved by assessing the database. Inclusion criteria were being older than 30 years of age and having ICD-O-3 topography and morphology codes related to MM. A board of expert pathologists reviewed the pathology reports and requested paraffin blocks in cases that demanded revision. After staining with calretinin, D2-40, WT-1 (as positive MM markers) and Ber-EP4 and MOC31 (as negative MM markers), cases were divided and studied independently by a pair of pathologists to confirm or discard the diagnosis of MM. Results: Our sample comprised 482 cases from 25 hospitals, and 130 needed further histological revision. We received 73 paraffin blocks with adequate material. After board analysis, there were 9 cases with a definitive diagnosis of MM, improving the diagnostic rate in 12%. Two cases of previously diagnosed MM were discarded by review. Conclusions: Our results confirm that part of MM underdiagnosis and underreporting in Brazil is due to incomplete or mistaken pathological diagnosis.

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Analysis of Mortality from Asbestos-Related Diseases in Brazil Using Multiple Health Information Systems, 1996–2017

Cited by 7 publications

References 28 publications

Asbestos ban policies and mesothelioma mortality in Greece

Asbestos ban policies and mesothelioma mortality in Greece

Asbestos Ban Policies and Mesothelioma Mortality in Greece

Identifying malignant mesothelioma by a pathological survey using the São Paulo state hospital cancer registry, Brazil

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