Analysis of molecular interactions in poly(methacrylic acid-g-ethylene glycol) hydrogels

Kim, Bumsang; Peppas, Nicholas A.

doi:10.1016/s0032-3861(03)00307-0

Cited by 55 publications

(34 citation statements)

References 27 publications

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“…However, under the basic and neutral conditions of the intestine, the gels are swollen to a high degree, because of electrostatic repulsions, so the percent of released drug is 45%. Kim and Peppas 19 observed that PEG-PMAA based hydrogels could adhere more strongly to the mucosa of the intestine than to the mucosa of the stomach, and this can localize the delivery system in a site-specific manner. The poly(MMA-co-AGA-co-MPEG) MGs, which are stable for long time release applications because of their hydrophobic core and hydrophilic shell structure (see Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it is a promising candidate for the delivery of environmentally susceptible bioactive agents that are characterized by poor absorption through the intestinal wall. 19,20 Maleic acid copolymers have been known to possess antimicrobial and antitumor activity, in particular. 21,22 Stover and coworkers used maleic anhydride copolymers to investigate the temperature and pH sensitivity of PEG-grafted poly(styrene-alt-maleic anhydride) in aqueous solutions.…”

Section: Introductionmentioning

confidence: 99%

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PMMA‐based microgels for controlled release of an anticancer drug

Rao

Chung

Reddy

et al. 2008

J of Applied Polymer Sci

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Methyl methacrylate (MMA), methoxy poly (ethylene glycol) monomaleate (MPEG), and acrylamidoglycolic acid (AGA) terpolymeric microgels (MGs) have been synthesized by free-radical surfactant-free emulsion polymerization. MPEG was synthesized from maleic anhydride and methoxy poly(ethylene glycol). The MGs were crosslinked with ethylene glycol dimethacrylate, and the chemical crosslinking was confirmed by Fourier transform infrared spectroscopy. 5-Fluorouracil (5-FU), a model anticancer drug, has been loaded into the MGs by in situ and adsorption methods. Empty as well as drug-loaded MGs were then characterized by transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and Xray diffraction (XRD). DSC and XRD studies indicated a molecular level dispersion of the drug in PMMA MGs during in situ loading. TEM images showed the formation of spherical MGs. In vitro release of 5-FU from the crosslinked poly(MMA-co-AGA-co-MPEG) MGs were investigated at both pH 7.4 and 1.2 buffer medium that controlled release of the drug up to $ 18 h. Both the encapsulation efficiency and the release patterns were dependent on the amount of crosslinking agent and the amount of drug loaded.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

PMMA‐based microgels for controlled release of an anticancer drug

Rao

Chung

Reddy

et al. 2008

J of Applied Polymer Sci

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“…Fourier transform infrared spectroscopy (FTIR) has been widely used to detect the molecular interaction in the PMAA blend systems [23,24]. The FTIR spectra in the range of 3800-2900 cm À1 , 1860-1575 cm À1 and 1590-1480 cm À1 are shown in Fig.…”

Section: Interaction Between Ipn Polymersmentioning

confidence: 99%

A fast pH-responsive IPN hydrogel: Synthesis and controlled drug delivery

Wang

2010

Reactive and Functional Polymers

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“…These hydrogels are characterized by the association of chemical groups belonging to different polymer chains. Hydrogen bonding, among others, is one of the interactions responsible for these chemical associations between macromolecular chains [31][32][33].…”

Section: Introductionmentioning

confidence: 99%