Analysis of mobile chemicals in the aquatic environment—current capabilities, limitations and future perspectives

Zahn, Daniel; Neuwald, Isabelle J.; Knepper, Thomas P.

doi:10.1007/s00216-020-02520-z

Cited by 45 publications

(43 citation statements)

References 140 publications

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“…This condition is a common trait in organisms adapted to have a rapid response to the presence of a new stressor [335][336][337]. Danio rerio PFOA CAT inhibition 7 , cat down-regulation 8 , prdx down-regulation 8 [281] Table 2. Cont.…”

Section: Biomolecular Datamentioning

confidence: 99%

“…1 2 ,7 -dichlorofluorescein deacetate; 2 malondialdehyde; 3 4-chloro-1-methyl-7-trifluoromethylquinolinium methylsulfate; 4 enzymatic activity; 5 quantitative real-time PCR; 6 thiobarbituric acid reactive species; 7 MALDI-TOF-TOF mass spectrometry; 8 microarray; 9 comet assay; 10 total antioxidant capacity; 11 FACSort flow cytometry; 12 E-SCREEN bioassay; 13 Coat-a-count radioimmunoassay; 14 serum creatinine; 15 Ortho VITROS Clinical Analyzer; 16 enzymatic assay; 17 immunoenzymometric assay; 18 liquid chromatography-tandem mass spectrometry; 19 Enzyme Linked ImmunoSorbent Assay; 20 gas chromatography-mass spectrometry; 21 AutoDELFIA fully automated system; 22 isometric assay; 23 Wester blotting; 24 transactivation assay; 25 MitoSOX™ Red mitochondrial superoxide indicator; 26 ATP colorimetric assay; 27 10-N-nonyl-Acridine Orange; 28 mass spectrometry.…”

Section: Pfas Effects Referencesmentioning

confidence: 99%

“…Public Health 2020, 17, 8020 2 of 45 accumulation matrix is water (including water contained in the biological tissues). For this reason, the exposure to PMOC can lead to serious health effects, which in many cases cannot be adequately assessed because the lack of monitoring and eco-toxicological data [7]. This is the case of the most important family of PMOC, which are the perfluorinated substances (PFAS).…”

Section: Introductionmentioning

confidence: 99%

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PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in the Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders, and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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Section: Biomolecular Datamentioning

confidence: 99%

Section: Pfas Effects Referencesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato

Corrà

Belli̇o

et al. 2020

IJERPH

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“…Since they degrade very slowly, PMOC are extremely mobile in aqueous medium and their preferable accumulation matrix is water (including water contained in the biological tissues). For this reason, the exposure to PMOC can lead to serious health effects, which in many cases cannot be adequately assessed because the lack of monitoring and eco-toxicological data [7]. This is the case of the most important family of PMOC, which are the perfluorinated substances (PFAS).…”

Section: Introductionmentioning

confidence: 99%

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Bonato¹,

Corrà²,

Belli̇o³

et al. 2020

Preprint

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Due to their unique properties, perfluorinated substances (PFAS) are widely used in multiple industrial and commercial applications, but they are toxic for animals, humans included. This review presents some available data on the PFAS environmental distribution in the world, and in particular in Europe and in Veneto region of Italy, where it has become a serious problem for human health. The consumption of contaminated food and drinking water is considered one of the major source of exposure for humans. Worldwide epidemiological studies report the negative effects that PFAS have on human health, due to environmental pollution, including infertility, steroid hormone perturbation, thyroid, liver and kidney disorders and metabolic disfunctions. In vitro and in vivo researches correlated PFAS exposure to oxidative stress effects (in mammals as well as in other vertebrates of human interest), produced by a PFAS-induced increase of reactive oxygen species formation. The cellular antioxidant defense system is activated by PFAS, but it is only partially able to avoid the oxidative damage to biomolecules.

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“…Mass spectrometry (MS) is the detection method of choice to reach the required detection limits, as it provides identification strength and an additional separation dimension when coupled to the various separation techniques [3]. Current screening and environmental monitoring strategies for micropollutants often rely on solid-phase extraction (SPE) for sample preparation and liquid chromatography (LC), mostly C18 reversed phase (RP) stationary phases, for separation.…”

Section: Introductionmentioning

confidence: 99%

Trends in sample preparation and separation methods for the analysis of very polar and ionic compounds in environmental water and biota samples

2020

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Recent years showed a boost in knowledge about the presence and fate of micropollutants in the environment. Instrumental and methodological developments mainly in liquid chromatography coupled to mass spectrometry hold a large share in this success story. These techniques soon complemented gas chromatography and enabled the analysis of more polar compounds including pesticides but also household chemicals, food additives, and pharmaceuticals often present as traces in surface waters. In parallel, sample preparation techniques evolved to extract and enrich these compounds from biota and water samples. This review article looks at very polar and ionic compounds using the criterion log P ≤ 1. Considering about 240 compounds, we show that (simulated) log D values are often even lower than the corresponding log P values due to ionization of the compounds at our reference pH of 7.4. High polarity and charge are still challenging characteristics in the analysis of micropollutants and these compounds are hardly covered in current monitoring strategies of water samples. The situation is even more challenging in biota analysis given the large number of matrix constituents with similar properties. Currently, a large number of sample preparation and separation approaches are developed to meet the challenges of the analysis of very polar and ionic compounds. In addition to reviewing them, we discuss some trends: for sample preparation, preconcentration and purification efforts by SPE will continue, possibly using upcoming mixed-mode stationary phases and mixed beds in order to increase comprehensiveness in monitoring applications. For biota analysis, miniaturization and parallelization are aspects of future research. For ionic or ionizable compounds, we see electromembrane extraction as a method of choice with a high potential to increase throughput by automation. For separation, predominantly coupled to mass spectrometry, hydrophilic interaction liquid chromatography applications will increase as the polarity range ideally complements reversed phase liquid chromatography, and instrumentation and expertise are available in most laboratories. Two-dimensional applications have not yet reached maturity in liquid-phase separations to be applied in higher throughput. Possibly, the development and commercial availability of mixed-mode stationary phases make 2D applications obsolete in semi-targeted applications. An interesting alternative will enter routine analysis soon: supercritical fluid chromatography demonstrated an impressive analyte coverage but also the possibility to tailor selectivity for targeted approaches. For ionic and ionizable micropollutants, ion chromatography and capillary electrophoresis are amenable but may be used only for specialized applications such as the analysis of halogenated acids when aspects like desalting and preconcentration are solved and the key advantages are fully elaborated by further research.

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Analysis of mobile chemicals in the aquatic environment—current capabilities, limitations and future perspectives

Cited by 45 publications

References 140 publications

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field

Trends in sample preparation and separation methods for the analysis of very polar and ionic compounds in environmental water and biota samples

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