Analysis of Mitochondrial DNA variation in the population of oroks

Bermisheva, Marina; Kutuev, I. A.; Spitsyn, V. A.; Villems, R.; Batyrova, A. Z.; Korshunova, T. Yu.; Хуснутдинова, Э. К.

doi:10.1007/s11177-005-0010-3

Cited by 5 publications

(7 citation statements)

References 23 publications

(32 reference statements)

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“…In Europe, the dense and extensive sampling of the HVR-I diversity has revealed extremely low frequencies of hg C1, with very few haplotypes found in Germans [14], Canarians [15], Icelanders [16]–[17] and Bashkirs [18] (Figure 2). These sequences lack HVR-I Single Nucleotide Polymorphisms (SNPs) diagnostic of the sub-clades C1a (T16356C) and C1d (A16051G).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial Genome Sequencing in Mesolithic North East Europe Unearths a New Sub-Clade within the Broadly Distributed Human Haplogroup C1

et al. 2014

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The human mitochondrial haplogroup C1 has a broad global distribution but is extremely rare in Europe today. Recent ancient DNA evidence has demonstrated its presence in European Mesolithic individuals. Three individuals from the 7,500 year old Mesolithic site of Yuzhnyy Oleni Ostrov, Western Russia, could be assigned to haplogroup C1 based on mitochondrial hypervariable region I sequences. However, hypervariable region I data alone could not provide enough resolution to establish the phylogenetic relationship of these Mesolithic haplotypes with haplogroup C1 mitochondrial DNA sequences found today in populations of Europe, Asia and the Americas. In order to obtain high-resolution data and shed light on the origin of this European Mesolithic C1 haplotype, we target-enriched and sequenced the complete mitochondrial genome of one Yuzhnyy Oleni Ostrov C1 individual. The updated phylogeny of C1 haplogroups indicated that the Yuzhnyy Oleni Ostrov haplotype represents a new distinct clade, provisionally coined “C1f”. We show that all three C1 carriers of Yuzhnyy Oleni Ostrov belong to this clade. No haplotype closely related to the C1f sequence could be found in the large current database of ancient and present-day mitochondrial genomes. Hence, we have discovered past human mitochondrial diversity that has not been observed in modern-day populations so far. The lack of positive matches in modern populations may be explained by under-sampling of rare modern C1 carriers or by demographic processes, population extinction or replacement, that may have impacted on populations of Northeast Europe since prehistoric times.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial Genome Sequencing in Mesolithic North East Europe Unearths a New Sub-Clade within the Broadly Distributed Human Haplogroup C1

et al. 2014

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“…We found six haplotypes from haplogroups C, D4 and M10 (Table 1). Haplogroup D4 has a high distribution frequency (8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22).3%) in northern Asians 7,8 and eastern Asians. 9 Haplogroup C has a very high distribution frequency (15.9-67.2%) in Siberia, 7 but a low frequency in China (3.5%).…”

Section: Resultsmentioning

confidence: 99%

“…9 Haplogroup M10 is a new subhaplogroup of M 10 with a frequency range of 0-2.3% in modern Han Chinese, 11 while a few M10 individuals have also been found among Mongolians and Yakuts. 8,12 A phylogenetic tree was constructed to determine the genetic relationship between the ancient Pengyang people and related populations ( Figure 2). In haplogroup C, the Han Chinese originating from the farming people 1,9,10 are concentrated in one group.…”

Section: Resultsmentioning

confidence: 99%

“…In haplogroup C, the Han Chinese originating from the farming people 1,9,10 are concentrated in one group. Meanwhile, PW4 is clustered into another group with minorities in northern China, northern Asians and ancient nomads, 2,7,[12][13][14][15][16][17][18][19] suggesting that PW4 is closely related to the nomads. In haplogroups D4 and M10, the ancient people from Pengyang consistently occupy the same nodes as northern Asians, northern minorities of China and ancient nomads, showing a close genetic relationship among them.…”

Section: Resultsmentioning

confidence: 99%

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Ancient DNA from nomads in 2500-year-old archeological sites of Pengyang, China

Zhao

et al. 2010

J Hum Genet

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Six human remains (dating B2500 years ago) were excavated from Pengyang, China, an area occupied by both ancient nomadic and farming people. The funerary objects found with these remains suggested they were nomads. To further confirm their ancestry, we analyzed both the maternal lineages and paternal lineages of the ancient DNA. From the mitochondrial DNA, six haplotypes were identified as three haplogroups: C, D4 and M10. The haplotype-sharing populations and phylogenetic analyses revealed that these individuals were closely associated with the ancient Xiongnu and modern northern Asians. Single-nucleotide polymorphism analysis of Y chromosomes from four male samples that were typed as haplogroup Q indicated that these people had originated in Siberia. These results show that these ancient people from Pengyang present a close genetic affinity to nomadic people, indicating that northern nomads had reached the Central Plain area of China nearly 2500 years ago.

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“…The same may be true for the low genetic diversities found in most southeast Siberian populations compared with East Asian populations (Table 3). Anthropologically, the Udegeys are characterized by a complex of morphological traits typical of the Mongolians and/or Baikal type, which bring them close to Evens, Evenki, Manchurians, and Negidalts (Smolyak, 1975;Crawford et al, 2002;Bermisheva et al, 2005). It has also been widely suggested that they have migrated to the territories of the Amur River basin from an area around Lake Baikal in south Siberia (Smolyak, 1975;Alexeev and Gohman, 1984).…”

Section: Resultsmentioning

confidence: 99%

Genetic diversity of two haploid markers in the Udegey population from southeastern Siberia

Huang

Kim

2009

American J Phys Anthropol

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The Udegeys are a small ethnic group who live along the tributaries of the Amur River Basin of southeastern Siberia in Russia. They are thought to speak a language belonging to a subdivision of the Tungusic-Manchu branch of the Altaic family. To understand the genetic features and genetic history of the Udegeys, we analyzed two haploid markers, mitochondrial DNA (mtDNA), and Y-chromosomal variation, in 51 individuals (including 21 males) from the Udegey population. In general, the Udegeys' mtDNA profiles revealed similarities to Siberians and other northeastern Asian populations, although a moderate European contribution was also detected. Interestingly, pairwise values of F(ST) and the MDS plots based on the mtDNA variation showed that the Orok and Nivkh inhabiting the very same region of the Udegey were significantly different from the Udegey, implying that they may have been isolated and undergone substantial genetic drift. The Udegeys were characterized by a high frequency (66.7%) of Y chromosome haplogroup C, indicating a close genetic relationship with Mongolians and Siberians. On the paternal side, however, very little admixture was observed between the Udegeys and Europeans. Thus, the combined haploid genetic markers of both mtDNA and the Y chromosome imply that the Udegeys are overall closest to Siberians and northeast Asians of the Altaic linguistic family, with a minor maternal contribution from the European part of the continent.

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Analysis of Mitochondrial DNA variation in the population of oroks

Cited by 5 publications

References 23 publications

Mitochondrial Genome Sequencing in Mesolithic North East Europe Unearths a New Sub-Clade within the Broadly Distributed Human Haplogroup C1

Mitochondrial Genome Sequencing in Mesolithic North East Europe Unearths a New Sub-Clade within the Broadly Distributed Human Haplogroup C1

Ancient DNA from nomads in 2500-year-old archeological sites of Pengyang, China

Genetic diversity of two haploid markers in the Udegey population from southeastern Siberia

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