The present study aims to compare the quantitative determination of metformin hydrochloride brands available in Malaysia by spectroscopic method and Fourier transform infrared spectroscopy. Several different commercially available leading brands of metformin, within their shelf-life were purchase from various pharmacy outlets in Sungai Petani, Malaysia. Each brand of metformin hydrochloride tablets was labelled to contain 500 mg of metformin hydrochloride. The metformin tablets were blindly named as Brand A, Brand B, Brand C, Brand D, Brand E, Brand F and G by spectroscopic method and Fourier transform infrared spectroscopy in the present study. The average percentage purity of sample A, B, C, D, E, F and G was 99.15%, 99.03%, 99%, 99.66%, 98.31%, 99.42% and 99.38%. The brand A, B, C, D, F, and G passed the test whereas brand E failed the test according to the United States Pharmacopeia (USP). Several brands of Metformin Hydrochloride being assessed in this research, it showed that most of the brands were within the pharmacopoeia limits for various quality control parameters except one. Through the FTIR spectral measurements, a satisfactory vibrational band assignment of metformin hydrochloride has been carried out.From the outcome of the various tests, it indicated that the process validation data provides a high degree of assurance of the manufacturing of these tablets' products meet its predetermined specification and quality attributes.